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Dr Jillian Broadbear
Biography
Jillian (BSc Monash University, 1988) completed her doctoral studies at the University of Michigan in Ann Arbor, Michigan, USA. Her doctoral research focused on whether the release of hypothalamic-pituitary-adrenal ("stress") hormones was an important factor in controlling drug-maintained behaviours in rhesus monkeys. In the years subsequent to the completion of her thesis, Jillian has expanded her early findings to include the effects of different classes of abused drugs on stress hormone secretion in monkeys, as well as examining sex differences in the effects of antidepressant treatment on stress hormone secretion in sheep. More recently she has been exploring the modulatory effects of the neurohormone, oxytocin, on mood (depression and anxiety), as well as its contribution to the subjective effects experienced after taking drugs of abuse. Jillian’s research includes the investigation of psychoactive drugs in humans, examining their effects on health and performance.
Jillian is currently a senior lecturer in the School of Psychology, Psychiatry and Psychological Medicine at Monash University (Clayton campus). She heads the Behavioural and Psychopharmacology Laboratory, investigating animal models of depression, anxiety and substance abuse, as well as evaluating psychoactive compounds in normal and clinical populations. Jillian has 34 publications in peer-reviewed scientific journals and has presented her research findings at 21 national and international conferences
Jillian heads the Behavioural and Psychopharmacology Group
- Invited NH&MRC reviewer
- Faculty Board
- Faculty Promotions Committee
- SPPPM Animal Ethics Committee
- SPPPM Research Committee
- Unit Coordination (PSY2031, DPSY6203, DPSY6105)
Jillian's research interests include the examination of mechanisms that contribute to drug discrimination and reward, as well as investigating the neuroendocrinological mechanisms that underlie psychoactive drug effects. She is currently investigating the interactions between antidepressant and anxiolytic medication, gender and neurohormones in behavioural models of affective disorders in animals and humans.
- Roles of neuromodulatory hormones that are predictive of antidepressant and anxiolytic efficacy in animal models
- Examination of the consequences of repeated drug exposure and neurological and behavioural change in humans and animals
- Investigation of the effects of exercise and environment on measures of depression and anxiety-like behaviour
- Examination of the relationship between the endocrinological environment during development and the emergence of autism-like behavioural traits
- Can’t we come up with something better than Valium for treating anxiety? Investigating a range of novel anxiolytic drugs using the cat odour avoidance test in rats
- How can we reduce morphine’s abuse liability when it is needed for the treatment of acute and chronic pain states? Combination therapy and conditioned place preference in the rat.
- Examining the role of exercise and environmental enrichment in mood and neuroplasticity: Is exercise a natural antidepressant?
Senior Lecturer in Undergraduate and Postgraduate Psychology and Behavioural Neuroscience:
- BNS2011 - Brain Structure and Function
- BNS3052 - Drugs, Brain and Altered Awareness
- PSY2031 - Developmental and Biology Psychology (Coordinator)
- BNS3021 - Neurochemistry and Behaviour
- BNS2082 - Behavioural Neuroscience Research Elective
- PSY3032 - Abnormal Psychology
- PSY3109 - Addiction Studies
- DPSY6105 - Psychopharmacology (Clinical Neuropsychology; Coordinator)
- DPSY6203 - Psychopharmacology (Clinical; Coordinator)
Student supervision
Current supervisor of three Psychology (Hon) students; cosupervisor of one BBNSc(Hon) student and one BSc(Hon) student with A/Prof. Ramesh Rajan (Physiology)
PhD(Psychology) student, Rowan Ogeil (with A/Prof. Shantha Rajaratnam)
PhD(Psychology) student, Kristina Vacy
- Co-supervising a Doctor of Philosophy student with Assoc. Prof. Shantha Rajaratnam
- Research collaboration with Prof. Susan Schenk and A/Prof. David Harper at Victoria University, Wellington, New Zealand
Chaviaras S, Ralph D, Krishnan L, Broadbear JH. Assessing the antidepressant-like effects of carbetocin, an oxytocin agonist, using a modification of the forced swimming test. J of Psychopharmacology (under review)
Broussard C, Broadbear JH. An anxiolytic-like effect of the oxytocin receptor agonist, carbetocin, on the elevated plus maze: A comparison with diazepam. Psychopharmacology (under review)
Parrott Andrew C, Broadbear Jillian, Bruno Raimondo, Degenhardt Louisa, Morefield Kate, Scholey Andrew B. MDMA (3,4-methylenedioxymethamphetamiine): neurohormonal, neurocognitive, and psychobiological aspects of recreational Ecstasy. Open Addiction Journal (accepted July 09)
Allott K, Canny BJ, Broadbear JH, Stepto N, Murphy B, Redman J: Neuroendocrine and subjective responses to pharmacological challenge with citalopram: A controlled study in male and female ecstasy/MDMA users. Journal of Psychopharmacology 23(7):759-774,2009.
Beringer K and Broadbear JH. Oxytocin as a mediator of the unique interoceptive effects of 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) in the rat. Conference Proceedings of the Australian Psychological Society, September 2008.
Gurtman C, Broadbear JH, Redman JR. Effects of modafinil on simulator driving and self-assessment of driving following sleep deprivation. Human Psychopharmacology: Clinical and Experimental 23: 681–692, 2008.
Broadbear JH: Corticotrophin Releasing Hormone in Non-Human Primates. (Invited review) Frontiers in Bioscience 11: 2303-2335, 2006
Broadbear JH, Pierce BN, Clarke IJ and Canny BJ: Role of sex and sex steroids in mediating pituitary-adrenal responses to buspirone in the sheep. Journal of Neuroendocrinology 17(12): 804-810, 2005
Broadbear JH, Winger G, and Woods JH: Self-administration of methohexital, midazolam and ethanol: Effects on the pituitary-adrenal axis in rhesus monkeys. Psychopharmacology 178: 83-91, 2005
Broadbear JH, Winger G, and Woods JH: Self-administration of cocaine, fentanyl and ketamine: Effects on the pituitary-adrenal axis in rhesus monkeys. Psychopharmacology 176: 398-406, 2004.
Broadbear JH, Nguyen T, Clarke IJ and Canny BJ: Antidepressants, sex steroids and pituitary-adrenal response in sheep. Psychopharmacology 175: 247-55, 2004
Broadbear JH, Winger G, Rivier JE, Rice KC and Woods JH: Corticotropin-releasing-hormone antagonists, astressin B and antalarmin: Differing profiles of activity in rhesus monkeys. Neuropsychopharmacology 29: 1112-21, 2004.
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