Chronic disease and related health problems are increasing in prevalence in Australia. Recent estimates suggest that Type 2 diabetes and heart disease cost the Australian community almost $9 billion in direct costs per annum. People with chronic conditions follow medical and behavioural prescriptions variably, however, while also using complementary and alternative (CAM) therapies, practitioners, vitamins and herbs. We will explore the reasons for presentation to and use of CAM practitioners and therapies by people diagnosed with and under treatment for two of the most commonly diagnosed chronic conditions - cardiovascular disease and diabetes - in order to establish the relationship with adherence to their prescribed treatment. The focus is on what is described as the “drivers, costs and benefits” of the use of CAM, and how the practical interaction of CAM and conventional health care approaches may support adherence. This research program will have very important implications for the control of these diseases and individual wellbeing. Using an innovative interdisciplinary approach and a mix of research methods, the research will provide a unique evidence-base on community approaches to and use of complementary and alternative medicine, and the significance of this to current and future health needs. The program will take advantage of the interdisciplinary skills in novel ways to explore areas of health and society that have so far received limited attention. By including two PhDs, we will strengthen Australia’s research capacity in health social sciences and public health in this field, generating new skills important to population health practice and policy in this country.