Respiratory medicine and thoracic surgery projects

Supervisor(s): Assoc Prof Philip Bardin
Location: Department of Surgery, Monash Medical Centre
Ph: 9594 2710
Email: Philip.Bardin@southernhealth.org.au

Description:
The basic science laboratories of our group are located in the Monash Institute of Medical Research (MIMR) and on the Clayton campus of our collaborator Prof David Jans. The laboratories are staffed by predominantly post-doctoral scientists with an interest in respiratory disease and virology with an emphasis on asthma and COPD. The studies below will provide an entry to laboratory science in a friendly collegial environment with an emphasis on translating basic science to the bedside. Some ongoing projects are listed below:

1. Chemokine responses to rhinovirus and RSV infection.
2. Allergic sensitisation of airway cells and responses to rhinoviruses and RSV.
3. The effect of epithelial cell infection with rhinoviruses on airway fibroblast cells.
4. Traffic of rhinovirus and RSV proteins into the cell nucleus and regulation of nuclear transport.
5. Cellular transdifferentiation and rhinovirus infection.
6. Growth and propagation of lung tissue from surgical resection specimens.
7. Growth and propagation of nasal tissue from surgical resection specimens.

Characterisation of cell growth ex vivo in tissues obtained from surgical specimens.
Cell death by necrosis and apoptosis in tissue explants generated from surgical specimens.