Monash Institute of Medical Research (MIMR)
Institute Director: Professor Bryan Williams
URL: http://www.monashinstitute.org/staff-bryan-williams.html
Centre for Cancer Research
Contact: Centre Director Professor Bryan Williams
Tel: +61 3 9594 7166
URL: http://www.monashinstitute.org/cancer-home.html
Key words: Tumours; tumourigenesis; oncogenesis; innate immunity; inflammation; RNA-binding proteins; protein kinase R; small interfering RNA; RNA interference; toll-like receptors; cytokines; interferon; promyelocytic zinc finger protein (PLZF); signal transduction; embryonic signalling pathways; Hedgehog (Hh) pathway; genetics; epigenetics; neural development; medulloblastoma; tumour stem cells; tumour suppressor genes; oncogenic signalling; cell surface receptors; monoclonal antibodies; targeted therapy; metastasis biology; cell adhesion signalling; cell adhesion receptors (integrins); integrin-linked kinase; cell migration; cardiac stem cells; metastasis; lymphoedema
Lay terms: Cancer; carcinogenesis; anti-cancer therapeutics; immunity; genes; stem cells; metastasis.
Disease Areas: Cancer; renal cell carcinoma; Wilms tumour; small cell lung cancer; glioma; prostate cancer; bladder cancer; breast cancer; viral infections
Expertise/Platform Technologies: RNA interference; high content screening; primary xenografts; monoclonal technologies; mouse cancer models; mouse cancer genetics; mouse cancer epigenetics; signal transduction
Centre for Innate Immunity and Infectious Disease (formerly Centre for Functional Genomics and Human Disease)
Contact: Centre Director Professor Paul Hertzog
Tel: +61 3 9594 7206
URL: http://www.monashinstitute.org/ciiid-home.html
Key words: Innate immunity, Interferons, interleukins, IL6, toll-like receptors (TLRs), inflammation, signal transduction pathways, NF?B, IRF, STATs, ETS factors, ligand-receptor interactions, cytokine signalling, SOCS-1, gp130-dependent signalling pathways
Lay description: Investigation into the molecular pathways that regulate the body?s response to inflammation, infectious disease and cancer
Disease areas: viral infections, gastric (stomach) cancer, gastritis (stomach inflammation), lung infection, lung inflammation, septic shock, mesothelioma (lung cancer), chronic inflammatory responses, hepatitis, chronic obstructive pulmonary disease (COPD), asthma
Expertise/Platform Technologies: bioinformatics integration of signalling components and pathways, gene targeting techniques, transcriptional regulation of gene expression, High Content Screening
Centre for Pain Medicine and Palliative Care
Contact: Centre Director Professor Colin Goodchild
Tel: +61 3 9594 7100
URL: http://www.monashinstitute.org/pain-med-home.html
Key words: Pain medicine, basic scientific and clinical studies of the physiology and pharmacology of pain, with particular emphasis on mechanisms at the level of the spinal cord.
Lay terms: Focus on the development of new and better methods to control distressing symptoms caused by acute and chronic illness such as pain, nausea and vomiting, drug-induced disorientation or sleepiness which all lead to a poor quality of life.
Disease areas: Acute postoperative pain; pain from degenerative disease such as arthritis; neuropathic pain caused by disease such as diabetes and HIV; cancer pain
Expertise/platform technologies: Anaesthesia and pain medicine; pain clinic and palliative care clinical practice; laboratory models of sedation, inflammatory pain, neuropathic pain (diabetes and nerve trauma); cancer pain
Centre for Reproduction and Development
Contact: Centre Director Professor Michael Holland
Tel: +61 3 9594 7400
URL: http://www.monashinstitute.org/crd.html
Key words: gametogenesis, germ cell biology, testicular cancer, reproductive endocrinology, activin, follistatin, genetics of male infertility, sperm structure, sperm function, epididymal biology, testicular immunobiology, assisted reproductive technologies, transgenesis, cloning livestock species, gene expression, pre-implantation embryo development, stem cell biology, embryonic stem cells (ESCs), somatic cell nuclear transfer (SCNT), induced pluripotent stem cells (iPSCs), cell fusion, placental stem cells, amnion-derived stem cells, Andrology Australia
Lay terms: Focus on reproductive technology, male reproductive function including infertility, contraceptive development, testis biology and immunology, the roles and functions of the testicular hormone activin, animal biotechnology including in vitro fertilization, cloning and stem cell research
Disease Areas: Stem cell therapies for a number of diseases, male infertility, testicular cancer, erectile dysfunction, activin in cancer, wound healing and cirrhosis of the liver
Expertise/Platform Technologies: Isolation and characterisation of embryonic stem cells from a number of species, assisted reproductive technologies including IVF, embryo transfer, and cloning, germ cell transplantation in the testis, genetics of infertility, reproductive endocrinology
Ritchie Centre for Baby Health Research
Contact: Acting Centre Director Dr Philip Berger
Tel: +61 3 9594 5474
URL: http://www.monashinstitute.org/baby-health.html
Key words: premature infants, blood pressure control, cerebral blood flow, lung regeneration, airway inflammation molecular biology, blood pressure control, brain metabolism in infants, brainstem control of spinal cord in early fetal life, movement disorders in infants, blood pressure control in premature infants, sleep disordered breathing, causes of apnea of prematurity, tissue oxygen supply during apnea, clinical management of paediatric sleep disorders, cardiovascular and neurocognitive effects of paediatric sleep disorders, genetics of breathing control abnormalities, long-term outcomes of premature infants with cardio-vascular disease, medical device innovation
Lay terms: Focus on investigating normal and abnormal growth and development of babies pre- and postnatally, with emphasis on the brain, heart and lungs. Collaborations with scientists, clinicians and engineers target understanding, diagnosis and treatment of common cardio-respiratory problems in the newborn.
Disease Areas: Sudden Infant Death Syndrome (SIDS), Down syndrome, chronic lung disease in premature infants, sleep apnea, obstructive apnea
Expertise/Platform Technologies: Use of acoustic technologies to monitor lung inflation and upper airway obstruction in the newborn and adult patient
Centre for Urological Research
Contact: Centre Direcctor Professor Gail Risbridger
Tel: +61 3 9594 7409
URL: http://www.monashinstitute.org/baby-health.html
Key words: Prostate; androgens; testosterone; estrogen; prostate development; prostate disease; human prostate stem cells; benign prostatic hyperplasia; BPH; hormone manipulation, tumour microenvironment, stroma, activin Beta-C, endocrine disruptors, estrogen receptors, aromatase, tumour suppressor gene, inhibin alpha unit, metastasis
Disease Areas: Prostate cancer; benign prostate hyperplasia (BPH); inflammation of the prostate (prostatitis)
Lay terms: Basic and translational research that will provide better diagnosis, treatment or prevention of prostate cancer, benign prostate hyperplasia and prostatitis.
Expertise/Platform Technologies: human and mouse pathology; image analyses and microscopy; tissue recombination; animal models of cancer; stem cell biology; pre-clinical drug testing; public education
Centre for Women's Health Research
Contact: Centre Director Professor Peter Rogers
Tel: +61 3 9594 5370
URL: http://www.monashinstitute.org/womens-health-research.html
Key words: Gynaecology and infertility; maternal-fetal medicine; endothelial cell biology; reproductive endocrinology; reproductive hormones; menstruation; fibroids; implantation; infertility; IVF; labour; trophoblast/placental function; regulation of placental blood flow; preterm labour; fetal growth; prenatal diagnosis; antenatal care; endometriosis; preeclampsia; ovarian cancer; molecular obstetrics; molecular gynaecology; virtual reality, computerized surgery, angiogenesis; neurodevelopment; bladder dysfunction
Lay terms: Disorders and diseases affecting women, pregnancy and newborn babies
Disease Areas: Endometriosis; menstrual dysfunction; endometrial cancer; breast cancer; ovarian cancer; uterine fibroids; infertility, pre-clampsia; miscarriage; preterm birth; intrauterine fetal growth restriction; cerebral palsy
Expertise/Platform Technologies: Clinical trials; clinical obstetrics and gynaecology; tissue banking; cell culture; stem cell biology; immunohistochemistry
Prospective Students
www.monashinstitute.org/for-students.html
PhD Students
Associate Professor Rosemary Horne
+61 3 9594 5700
Honours Students
Bachelor of Biomedical Sciences: Dr Elizabeth Williams
+61 3 9594 7164
Bachelor of Science / Bachelor of Medical Science: Professor Michael Holland
+61 3 9594 7400
Education Program in Reproduction and Development
- Master of Clinical Embryology
- Master of Reproductive Sciences
- Graduate Diploma in Reproductive Sciences
Contact: eprd@med.monash.edu.au
Tel: +61 3 9594 7360
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