Theme LeaderProfessor Mark Bellgrove
T: +61 3 9902 4200
E: Mark.Bellgrove@ monash.edu
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The human brain undergoes massive developmental change from infancy to early adulthood, underpinning age-related changes in cognitive ability, temperament, personality and social functioning. The consequences of disruption to neurodevelopment can be dramatic, as exemplified by the host of clinical conditions that are marked by a failure to attain appropriate cognitive, social or brain developmental milestones. Thus members of our theme seek to understand for example, how individual differences in our genetics might influence the development of traits such as inattention or impulsivity and their associated neural correlates. Other members of our theme lead the way in studying neurodevelopmental disorders, such as autism spectrum disorders, ADHD, Fragile X and William’s syndrome.
Our approach and methodology is strongly multidisciplinary. We integrate knowledge from genetics, pharmacology and behavioural, cognitive and developmental neuroscience with that of clinical psychology and psychiatry to enrich our understanding of developmental processes. We employ cutting edge technologies such as electroencephalography (EEG), oculomotor neurophysiology, transcranial magnetic stimulation (TMS) and structural and functional brain imaging to link brain and behaviour.
Our strong neuroscience focus combined with our rich clinical research ensures that our discoveries are relevant and translatable while being grounded in the biology of the disorders we study.
- Professor Mark Bellgrove awarded a prestigious Future Fellowship (Level 3) from the Australian Research Council (ARC).
- Professor Mark Bellgrove, Dr Ziarih Hawi, A/Prof M Arcos-Burgos, Professor S Easteal, Associate Professor A Vance, Professor F Levy and Dr Tarrant Cummins were awarded a NHMRC Project Grant, "The genetics of ADHD: role of rare variants" for funding commencing in 2014, $630,853
- Professor Mark Bellgrove and Associate Professor Redmond O’Connell were awarded an ARC Discovery Project Grant, "Dissecting the neural substrates of spatial attention" for funding commencing in 2015, $354,700
- Age and CGG-repeat length are associated with neuromotor impairments in at-risk females with the FMR1 premutation.
Kraan CM, Hocking DR, Georgiou-Karistianis N, Metcalfe SA, Archibald AD, Fielding J, Trollor J, Bradshaw JL, Cohen J, Cornish KM.Neurobiol Aging. 2014 Sep;35(9):2179.e7-13. doi: 10.1016/j.neurobiolaging.2014.03.018. Epub 2014 Mar 20.
- Exploring inhibitory deficits in female premutation carriers of fragile X syndrome: through eye movements.
Shelton AL, Cornish K, Kraan C, Georgiou-Karistianis N, Metcalfe SA, Bradshaw JL, Hocking DR, Archibald AD, Cohen J, Trollor JN, Fielding J. Brain Cogn. 2014 Mar;85:201-8. doi: 10.1016/j.bandc.2013.12.006. Epub 2014 Jan 11.
- Alpha-2A adrenergic receptor gene variants are associated with increased intra-individual variability in response time.
Cummins TD, Jacoby O, Hawi Z, Nandam LS, Byrne MA, Kim BN, Wagner J, Chambers CD,Bellgrove MA. Mol Psychiatry. 2014 Sep;19(9):1031-6. doi: 10.1038/mp.2013.140. Epub 2013 Oct 29.