The study of aged individuals with and without disease is becoming ever more significant as we live longer. We aim to understand brain-behaviour relationships in both healthy ageing and in individuals with neurodegenerative disorders including Huntington’s disease, Parkinson’s disease, Multiple Sclerosis, Freidriech ataxia, FXTAS (Fragile X-associated tremor/ataxia syndrome), and other associated dementias.
We lead the way in applying cutting edge clinical and experimental approaches to exploring linkages between brain mechanisms and the cognitive and motor signatures that characterise these disorders. Our research adopts state-of-the-art platform technology, including neuroimaging (e.g., MRI, EEG,TMS); neuromotor (e.g., eye-tracker, gait-mat); neurocognitive; and molecular genetics to better advance knowledge on variability of disease onset and progression. Our longitudinal assessments, with large patient cohorts, has generated significant datasets that has helped discover sensitive biomarkes of disease progression in ways that have clear potential for affecting treatment, some of which are currently being used in clinical trials.
We are at the forefront of new discovery as we work to bridge the gap between neurogenetics, brain imaging and behaviour; discover sensitive biomarkers for clinical trials; understand syndrome heterogeneity; and translate research breakthroughs directly into the clinic for improved health outcomes for patients.
- Georgiou-Karistianis, N. HD Research Around the World: Australia. HD Insights - Neuroimaging in Huntington’s disease: Future directions, Volume 9.
- Labuschagne, I. (2013). HD Research Around the World: Australia. HD Insights - A Huntington disease research periodical, Issue No. 5.
- NHMRC funded project: Prof Nellie Georgiou-Karistianis, Prof Gary Egan, Prof Martin Delatycki, Prof Elsdon Storey, Dr Andrew Churchyard, Dr Louise Corben; Longitudinal neuroimaging study investigating reorganisation of cerebellar-cerebral networks in Friedreich ataxia (2013-2017, $782,162)
- Novartis Non-Interventional Third Party Study: Dr Joanne Fielding Correlation of central nervous system structure and function in Multiple Sclerosis: is fingolimod neuroprotective? (2014-2017, $476,722)
- Tabrizi, S.J., Scahill, R., Durr, A., Roos, R.A.C., Leavitt, B.R., Jones, R., Landwehrmeyer, G.B., Fox, N.C., Johnson, H., Hicks, S.L., Kennard, C., Craufurd, D., Frost, C., Langbehn, D.R., Scahill, R.I., Stout, J.C. and Track-HD Investigators. (2011). Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurology, 10, 31-42.
- Tabrizi, S.J., Reilmann, R., Roos, R.A.C., Durr, A., Leavitt, B., Owen, G., Jones, R., Johnson, H., Craufurd, D., Hicks, S.L., Kennard, C., Landwehrmeyer, G.B., Stout, J.C., Borowsky, B., Scahill, R.I., Frost, C., Langbehn, D.R., and the TRACK-HD investigators. (2012). Potential endpoints for clinical trials in premanifest and early Huntington’s disease in the TRACK-HD study: analysis of 24 month observational data. Lancet Neurology Vol 11 (1) 42-53. doi:10.1016/S1474-4422(11)70263-0.
- Georgiou-Karistianis, N., Scahill, R., Tabrizi, S.J., Squitieri, F., & Aylward, E. (2013). Structural MRI in Huntington’s disease and recommendations for its potential use in clinical trials. Neuroscience & Biobehavioral Reviews, 37 (3), 480-490.
- Kolbe, S., Mitchell, P., Kilpatrick, T., White, O., Egan, G, & Fielding, J. (2013). Dysfunctional inhibitory eye movements are associated with cerebellar injury in multiple sclerosis. Human Brain Mapping, 35(5):2310-9.
- Shelton, A., Cornish, K., Kraan, C., Georgiou-Karistianis, N., Metcalfe, S., Bradshaw, J., Hocking, D., Archibald, A., Cohen, J., Trollor, J., & Fielding, J. (2014). Exploring inhibitory deficits in female premutation carriers of fragile X syndrome: Through eye movements. Brain and Cognition, 8:201-208.
- Poudel, G. R., Stout, J.C., Gray, M.A., Domínguez D, J.F., Salmon, L., Churchyard, A., Chua, P., Borowsky, B., Egan, G.F., & Georgiou-Karistianis, N. Functional changes during working memory in Huntington’s disease: 30 month longitudinal data from the IMAGE-HD study. Brain Structure and Function, in press 31 October, 2013.