Theme LeaderProfessor Murat Yucel
T: +61 3 990 29765
Substance dependence, problem gambling and excessive eating are common examples of addictions with high personal impact and societal costs. These addictive behaviours involve changes in the brain of those affected, making it harder for the person to stop. Individual differences in brain networks relevant to reward/punishment learning, cognitive control and decision-making predict vulnerability to addiction, and continued exposure to drugs and other powerful incentives (e.g., high palatable food or gambling) weakens the function of these systems. Therefore, we seek to understand how the core processes of reward/punishment learning, cognitive control and decision-making and their neural underpinnings contribute to vulnerability to addiction, to shape different forms of addiction and to influence recovery from addiction. By using a combination of genetic, neuroimaging, cognitive, personality and outcome measures, we seek to pave the way from vulnerability to expression of disease and recovery potential.
This research has the potential to contribute to (i) biologically-based and theory-driven classification and diagnosis of addictive disorders, (ii) better prognosis of treatments pathways and recovery outcomes, (iii) development of biomarkers of addiction recovery, and (iv) development of novel interventions to counteract addiction-related weakening of brain function.
Professor Murat Yücel was interviewed on the SBS documentary "Living with the Enemy: Marijuana" to discuss the effect of Marijuana on the brain and mental health.
Michael is Australia’s biggest public advocate for smoking Marijuana. He is ambassador for life at Nimbin’s Hemp Embassy, co-creator of Australia’s annual celebration of all things cannabis, Mardi Grass, a foundation member of the Help End Marijuana Prohibition (HEMP) political party, and a man who has smoked his own body weight in marijuana over the course of his lifetime. Kerryn is a former drug user who is now a passionate school drug and alcohol awareness educator and published author on the topic. Kerryn believes marijuana is the potential gateway to a lifetime of addiction and ruin. Kerryn introduce him to Prof. Murat Yucel at Monash Clinical Imaging and Neuroscience (MCIN) who used brain-imaging techniques to proved this negative effect on the brain. For the full video, please watch online at SBS.
Professor Murat Yücel joined the “Insight” program on SBS to discus the pro's and con's of Australia legalising the use of marijuana on 7th Oct 2014.
"... the decade of research that we've looked at where we study regular heavy users of cannabis, so we look at people who have been using almost daily, or close to daily, at least a few times a week, and when we look at those people we tend to find that about after seven to ten years of use as a general theme we're starting to pick up memory impairments, brain structural alterations and links to psychotic symptoms and disorder and so that's the findings we consistently find." For the full video, please watch online at SBS.
On ABC’s Catalyst, A/Professor Alex Fornito explains how brain imaging and the science of social networks are helping us understand friendships and other relations.
“… the medial prefrontal cortex… this part of the brain we know is involved in thinking about other people’s intentions, feeling empathy towards others and these are all skills that we think are really important for being able to make friends…. For the full video, please watch online at ABC Catalyst (Series 15, Ep 13 Falling in Friendship).
Monash Latest News : Brain changes may lengthen odds that gamblers can stop
...Gambling problems develop when certain areas in the brain known as ‘reward circuits’ begin to malfunction. A couple of the key brain networks relate to how we make predictions about and place ‘value’ on rewards and losses and how we exercise self control, each of which plays a part in everyday decisions including spending money and taking part in enjoyable activities, such as gambling.
- Please click here for the full story on Monash website.
- Please contact us, if you are interested in participating.
Doctors Beth Johnson and Nigel Rogasch speak about ‘Brain Machines’ (electroencephalography and transcranial magnetic stimulation) for the children’s science show ‘Scope’ on channel ten.
Beth and Nigel speak about some of the machines that they use to study the human brain on this Scope episode focusing on Body Science (S3 E12). Please click here to watch it online, skip forward to the 7:04 mark of the episode to watch their segment.
Professor Murat Yücel was interviewed on ABC radio in relation to the recent legalisation of cannabis in Colorado, US
...Monash University professor and clinical psychologist, Dr Murat Yücel says his research group studied the effects of daily cannabis users for more than ten years and have found links with many harmful effects."We look at things like their brain, their mental health, their psychological functioning, each of those domains with time and time again link cannabis exposure to reductions in brain volume, loss of learning and memory, increased rates and worst outcomes in terms of psychosis and depression on so on." ...Please click here for full details and record.
Carter, A, and W Hall. 2014. DrinkWise’s cynical campaign shouldn’t fool anyone. The Conversation. Accessed 14 September, 2014.
Carter, A, and W Hall. 2013. Deep brain stimulation: the hidden challenges of a technological fix. The Conversation. Accessed 22 May, 2013.
- Lubman DI, Cheetham A, Yücel M (In Press; October 2014) Cannabis and the adolescent brain: evidence for disrupted neurodevelopment. Pharmacology & Therapeutics
- Dwyer DB, Harrison BJ, Yücel, M, Whittle S, Zalesky A, Pantelis C, Allen NB, Fornito A (In Press; Accepted; September 2014) Large-scale brain network dynamics supporting adolescent cognitive control. Journal of Neuroscience
- Harding IH, Harrison BJ, Breakspear M, Pantelis C, Yücel M (In Press; Accepted August 2014) Cortical Representations of Cognitive Control and Working Memory are Dependent yet Non-Interacting. Cerebral Cortex
- Lorenzetti V, Solowij N, Whittle S, Fornito A, Lubman DI, Pantelis P, Yücel M (In Press; Accepted August 2014) Gross morphological changes of chronic, heavy cannabis use. British Journal of Psychiatry
- Fontenelle LF, Coutinho ESF, Lins-Martins NM, Fitzgerald PB, Fujiwara H, Yücel M (In Press, Accepted June 2014) Electroconvulsive therapy for obsessive-compulsive disorder: a systematic review. Journal of Clinical Psychiatry
- López-Solà C, Fontenelle LF, Alonso P, Cuadras D, Foley D, Pantelis C, Pujol J, Yücel M, Cardoner N, Soriano-Mas C, Menchón JM, Harrison BJ (2014) Prevalence and heritability of obsessive-compulsive spectrum and anxiety disorder symptoms: a survey of the Australian twin registry. American Journal of Medical Genetics 165(4):314-325.
- Goudriaan AE, Yücel M, van Holst RJ (2014) Getting a grip on problem gambling - What can neuroscience tell us? Frontiers in Behavioral Neuroscience. 8:141.
- Cheetham A, Allen NB, Whittle S, Dennison M, Simmons J, Yücel M, Lubman DI (2014) Psychiatric symptoms, affective temperament, and neuroanatomy prospectively predict alcohol-related problems in adolescence. Psychopharmacology 231(8):1731-42.
- Garfield JB, Lubman DI, Yücel M (2014). Anhedonia in substance use disorders: a systematic review of its nature, course and clinical correlates. Australian and New Zealand Journal of Psychiatry. .48(1):36-51.
- Sjoerds Z, Luigjes J, van den Brink W, Denys D, Yücel M (In Press; Accepted January 2014) The role of habits and motivation in human drug addiction; A reflection. Frontiers in Addictive Disorders and Behavioral Dyscontrol 5:8.
- Batalla A, Bhattacchyyria S, Yücel M, Fusar-Poli P, Crippa JA, Nogué S, Torrens M, Pujol J, Farré M, Martín-Santos R. (2013) Structural and functional imaging studies in chronic cannabis users: a systematic comparison of adolescent versus adult findings. PlosOne.8(2):e55821.
- Baker S, Yücel M, Fornito A, Allen NB, Lubman DI (2013) A systematic review of diffusion weighted MRI studies of white matter microstructure in adolescent substance users. Neuroscience and Biobehavioral Reviews 37(8):1713-1723.
- Solowij N, Walterfang M, Lubman DI, Whittle S, Lorenzetti V, Styner M, Velakoulis D, Pantelis C, Yücel M. (2013) Alteration to hippocampal shape in cannabis users with and without schizophrenia. Schizophrenia Research. 143(1):179-184.
- Verdejo-García A, Lubman DI, Roffel K, Vilar-López R, Bora E, MacKenzie T, Yücel M (2013) Cingulate biochemistry in heroin users on substitution pharmacotherapy. Australian and New Zealand Journal of Psychiatry. 47(3):244-249.
- Vilar-López R, Takagi M, Lubman DI, Cotton SM, Bora E, Verdejo-García A, Yücel M (2013) The effects of inhalant misuse on attentional networks. Developmental Neuropsychology 38(2):126-136.
- Mosley, P.E., W. Hall, C. Forlini, and A. Carter. in press. "Alienation and authenticity in Parkinson’s disease and its treatment: a response to Mecacci and Haselager." Neuroethics.
- Meurk, C, W Hall, A Carter, and H. J. Chenery. in press. "Collecting real-time data from substance users raises unique legal and ethical issues: reply to Kuntsche and Labhart." Addiction.
- Hall, W, A Carter, and C. Forlini. in press. "The NIDA “brain disease” model of addiction: Is it supported by the evidence and has it delivered on its promises?" Lancet Psychiatry.
- Hall, W, A Carter, and M Farrell. in press. "Compulsory addiction treatment in the patient’s best interests: More rigorous evaluations are essential." Drug and Alcohol Review.
- Meurk, C., B. Partridge, A. Carter, W. Hall, K. Morphett, and J. Lucke. 2014. "Public attitudes in Australia towards the claim that addiction is a (brain) disease." Drug and Alcohol Review 33 (3):272-279. doi: Doi 10.1111/Dar.12115.
- Hall, W., A. Carter, and M. Yucel. 2014. "Ethical issues in the neuroprediction of addiction risk and treatment response." In Handbook of Neuroethics, edited by N Levy and J Clause, 1025-1044. Heidelberg: Springer.
- Carter, Adrian, Rebecca Mathews, Stephanie Bell, Jayne Lucke, and Wayne Hall. 2014. "Control and Responsibility in Addicted Individuals: What do Addiction Neuroscientists and Clinicians Think?" Neuroethics 7 (2):205-214. doi: 10.1007/s12152-013-9196-6.
- Carter, A, and W Hall. 2014. "Introduction." In Handbook of Neuroethics, edited by N Levy and J Clause, 995-998. Heidelberg: Springer.
- Capps, B., A. Carter, and Y. Van Der Eijk. 2014. "Ethical issues in the treatment of addiction." In Handbook of Neuroethics, edited by N Levy and J Clausen, 1045-1063. Heidelberg: Springer.
- Bell, Stephanie, Adrian Carter, Rebecca Mathews, Coral Gartner, Jayne Lucke, and Wayne Hall. 2014. "Views of Addiction Neuroscientists and Clinicians on the Clinical Impact of a ‘Brain Disease Model of Addiction’." Neuroethics 7 (1):19-27. doi: 10.1007/s12152-013-9177-9.
- Morphett, K, J Lucke, C Gartner, A Carter, C Meurk, and W Hall. 2013. "Public attitudes towards the treatment of nicotine addiction." Nicotine & Tobacco Research in press.
- Meurk, Carla, Wayne Hall, Kylie Morphett, Adrian Carter, and Jayne Lucke. 2013. "What does ‘acceptance’mean? Public reflections on the idea that addiction is a brain disease." BioSocieties 8 (4):491-506.
- Meurk, C, A Carter, W Hall, and J Lucke. 2013. "Public understandings of addiction: the impact of addiction neuroscience research." Neuroethics in press.
- Lee, Natalia M., Jayne Lucke, Wayne D. Hall, Carla Meurk, Frances M. Boyle, and Adrian Carter. 2013. "Public Views on Food Addiction and Obesity: Implications for Policy and Treatment." PLoS ONE 8 (9):e74836. doi: 10.1371/journal.pone.0074836.
- Hall, W, and A Carter. 2013. "Anticipating possible policy uses of addiction neuroscience research." Drugs: Education, Prevention, and Policy 20 (3):249-257. doi: doi:10.3109/09687637.2013.779426.
- Hall, W, and A Carter. 2013. "Advocates for compulsory addiction treatment bear the burden of demonstrating its effectiveness, safety and ethical acceptability." Bulletin of the World Health Organization 91 (2):146.
- Hall, W, and A Carter. 2013. "A History of Drug Use in Australia." In Drug Use in Society, edited by M. Hamilton, A. Ritter and T. King. London: Oxford University Press.
- Carter, Adrian, and Wayne Hall. 2013. "Ethical implications of research on craving." Addictive Behaviors 38 (2):1593-1599. doi: http://dx.doi.org/10.1016/j.addbeh.2012.07.002.
- Carter, A., and W. Hall. 2013. "Ethical Issues in the Treatment of Drug Dependence." In Interventions for Addiction:Comprehensive Addictive Behaviors and Disorders, 611–620. San Diego: Academic Press.
- Carter, Adrian, and Wayne Hall. 2013. "Managing Suicide Risk in Experimental Treatments of Treatment-Resistant Depression." AJOB Neuroscience 4 (1):38-39. doi: 10.1080/21507740.2012.748706.
- Bartlett, F, W Hall, and A Carter. 2013. "Voluntariness and causation for criminal offending associated with treatment of Parkinson’s disease." Criminal Law Journal 37 (5):330-341.