Professor Iain Clarke
Department of Physiology,
Monash University VIC 3800 Australia
Room F275, Building 13F (Physiology)
Tel: +61 3 990 52554
Fax: +61 3 990 52566
Professor Clarke graduated from Massey University, New Zealand (B. Agric. Sci., 1971) followed by M. Agric. Sci. (1st Class) in reproductive physiology in 1973). He then obtained his PhD at Edinburgh University, Scotland in 1976, studying endocrinology and behaviour. He then moved to Australia and has been in Melbourne since 1977. He became a Senior Research Fellow of NHMRC in 1986, rising to Principal Research Fellow in 1991. He became Chairman, Department of Physiology, Monash University in 2007
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Prof has published 430 research papers and has received The Woodward Prize for Excellence in Research in Neuroscience (1992), a Senior Fulbright Award (1997), the Asia and Oceania Medal of The Endocrine Society (United Kingdom) in 2001 and the TransPacific Lecturership, Endocrine Society (USA) in 2004. Most recently (2009), he was the recipient of The Geoffrey Harris Memorial Award of the International Federation of Neuroendocrinology (2009).
Historical: Prof Clarke's seminal studies on the measurement of hypothalamic secretion of GnRH in sentient animals were published in 1982 and he has contributed extensively to the field of reproductive neuroendocrinology for 35 years. His laboratory expanded to embrace all many other aspects of neuroendocrinology and he currently devotes 50% of his research effort to the study of brain mechanisms that regulate food intake and energy expenditure. There are two main divisions in Professor Clarke's laboratory; reproduction in association with Dr Jeremy Smith and metabolic Neuroendocrinology, in association with Dr Belinda Henry.
In particular, his work has utilised sheep models, which allow a range of studies not easily undertaken in small laboratory species. He has developed a number of novel neuroendocrine methodologies that allow analysis ranging from the whole animal down to the singe cell and subcellular function. These techniques have enabled a range of national and international collaborations, with grant funding from Australian and offshore sources. In addition, his laboratory undertakes a range of contract research projects.
- His laboratory is currently focused on the following areas:-
- Central regulation of reproduction by kisspeptin and gonadotropin inhibitory hormone
- Estrogen signalling in neuroendocrine systems
- Control of food intake and energy expenditure by leptin and novel regulatory factors
- Melanocortins and reproduction
- Central regulation of energy expenditure
Strategic Committee International Society Neuroendocrinology
Organising Committee, International Farm Animal Endocrinology meeting 2011
Editorial Board, Endocrinology
Steering Committee (Programming) Endocrine Society (USA)
Homeostatic control of thermogenesis in skeletal muscle
Some recent publications are listed below
Henry, B.A., Andrews, Z., Rao, A. and Clarke, I.J. Central leptin activates mitochondrial function and increases heat production in skeletal muscle. Endocrinology 152: 2609-2618 2011. (Editors Choice).
Szymanski, L.A., Schneider, J.E., Satragno, A., Dunshea, F.R. and Clarke, I.J. Mesenteric infusion of a volatile fatty acid prevents body weight loss and transiently restores luteinising hormone secretion in ovariectomized, food-restricted ewes. Journal of Neuroendocrinology 23: 699-710 2011.
Li, Q., Rao, A., Pereira, A., Clarke, I.J. and Smith, J.T. Kisspeptin cells in the ovine arcuate nucleus express prolactin receptor but not melatonin receptor. Journal of Neuroendocrinology 23: 871-882, 2011.
Keenan, D.M., Clarke, I.J. and Veldhuis, J.D. Non-invasive analytical estimation of endogenous gonadotropin-releasing hormone (GnRH) drive: Analysis using graded competitive GnRH-receptor antagonism and a calibrating pulse of exogenous GnRH. Endocrinology 152: 4882-4893, 2011.
Li, Q., Rao, A., Clarke, I.J. and Smith, J.T. Seasonal variation in the GnRH response to kisspeptin in sheep: Possible kisspeptin regulation of the kisspeptin receptor. Neuroendocrinology. [Epub ahead of print] 14th Feb 2012.
McKinley, M.J, Clarke, I.J. and Oldfield, B.J. 'Circumventricular Organs' in ‘The Human Nervous System’, 3rd Edition, Ed G Paxinos. pp 594-617.
Clarke, S.D., Clarke, I.J., Rao, A., Cowley, M.A. and Henry, B.A. Sex differences in the metabolic effects of testosterone in sheep. Endocrinology 153: 123-131, 2012
Clarke, I.J., Smith, J.T., Henry, B.A., Oldfield, B.J., Stefanidis, A., Millar, R.P., Puspita Sari, I., Chng, J., Fabre-Nys, C., Caraty, A., Ang, B.T., Chan, C. and Fraley, G.S. Gonadotropin inhibitory hormone (GnIH) provides a switch between reproduction and feeding. Neuroendocrinology, 95: 305-316. 2012
Oheim, R., Barvencik, F., Beil, F.T., Clarke, I.J. and Amling, M. Targeting the lateral but not the third ventricle induces bone loss in ewe. An experimental approach to generate an imoroved large animal model of osteoporosis. J Trauma Acute Care Surg72(3):720-726. 2012
Beil, F.T., Barvencik, F., Hissnauer, T.N., Pestka, J.M., Reusch, M., Ignatius, A., Rueger, J.M., Schinke, T., Clarke, I.J., Amling, M. and Pogoda, P. Low turnover osteoporosis in sheep by hypothalamic-pituitary disconnection. J Orthop Res. 30: 1254-1262. 2012
Clarke, S., Lee, K., Andrews, Z.B., Farhi, F., Evans, R., Clarke, I.J. and Henry, B.A. Post-prandial heat production is associated with altered mitochondrial function. Am J Physiol. In Press, Oct 2012
Smith, J.T., Young, I.R., Veldhuis, J.D. and Clarke, I.J. Gonadotropin inhibitory hormone (GnIH) secretion into the hypophysial portal system. Endocrinology, 153(7):3368-75 2012
An image of a slice through a gonadotropin releasing hormone neuron (red) showing input from gonadotropin inhibitory hormone terminals (green). From Qi et al. (2009) J Neuroendo 21:690.
2013-2015 Henry, B.A. and Clarke, I.J. ‘Sex, Stress and Obesity’.
|$240,738 – 2013
$240,738 – 2014
$240,738 – 2015
|2012-2014 Clarke, I.J., Smith, J.T., Parkington, H. ‘Gonadotropin Inhibitory Hormone (GnIH); a negative regulator of Reproduction’.
|2011-2013 Henry, B.A., Clarke, I.J., Andrews, Z. ‘Muscle thermogenesis in models of predisposition to obesity’.
$171,262 – 2011
|2011-2013 Oldfield, B.J., Clarke, I.J., ‘The differential innervations of fat – Potential to target visceral adiposity’.
$151,174 – 2011
Back (from left): Dr Kevin Lee, Dr Ross Young & Bruce Doughton
Second Row (from left): Mandy Curd & Sakda Hewagalamulage
Second Bottom Row (from left): Alix Rao, Rachael Loughnan & Professor Iain Clarke
Bottom Row (from left): Dr Qun Li, Elaine Chase, Dr Belinda Henry & Alda Pereira