Fetal & Neonatal Lung Development Laboratory

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Publications - Dr. Hooper

1. Harding, R., Tester, M.L., Moss, T.J., Davey, M.G., Louey, S., Joyce, B. Hooper, S.B. and Maritz, G.  (2000).  Effects of intra-uterine growth restriction on the control of breathing and lung development after birth. Clinical and Experimental Pharmacology and Physiology 27: 114-119.

2. Nardo, L., Maritz, G., Harding, R and Hooper, S.B. (2000) Changes in lung structure and cellular division induced by tracheal obstruction in fetal sheep. Experimental Lung Research 26(2): 105-119.

3. Harding, R., Cock, M.L., Louey, S., Joyce, B.J., Davey, M.G., Albuquerque, C.A, Hooper, S.B. and Maritz, G.S. (2000). The compromised intra-uterine environment: implications for future lung health. Clinical and Experimental Pharmacology and Physiology 27:965-974.

4. Nardo, L., Young, I.R. and Hooper, S.B. (2000).  Influence of growth hormone on the lung growth response to tracheal obstruction in fetal sheep. American Journal of Physiology 278:L453-L459.

5. Flecknoe, S., Harding, R., Maritz,G. and Hooper, S.B. (2000). Increased lung expansion alters the proportions of Type-I and Type-II alveolar epithelial cells in fetal sheep. American Journal of Physiology 278: L1180-L1187.

6. Probyn, M.E., Wallace, M.J. and Hooper, S.B. (2000). Effect of increased lung expansion on lung growth and development near mid-gestation in fetal sheep. Pediatric Research. 47:806-812

7. Hooper, S.B. and Harding R. (2001) Respiratory System. In: Textbook of Fetal Development. Eds. R. Harding & A.D. Bocking. Cambridge University Press Ch 6.  pp. 114-136.

8. Cock, M.L., Albuqerque, C.A., Joyce, B.J., Hooper, S.B. and Harding, R. (2001).  Effects of Intrauterine growth restriction on lung liquid dynamics and lung development in fetal sheep. American Journal of Obstetrics and Gynecology. 184:209-216.

9. Lines, A., Gillett, A.M. Wallace, M.J., Phillips, I.D. and Hooper S.B. (2001) Re-expression of pulmonary surfactant proteins following tracheal obstruction in fetal sheep. Experimental Physiology. 86:55-63.

10. Jenkin, G., Ward, J., Hooper, S.B., O’Connor, A. de Kretser, D. and Wallace, E. (2001). Feto-placental hypoxemia regulates the release of fetal activin A and prostaglandin E₂. Endocrinology 142:963-966.

11. Joyce, B.J., Louey, S., Davey, M.G., Cock, M.L., Hooper, S.B. and Harding, R. (2001). Compromised respiratory function in postnatal lambs after placental insufficiency and intrauterine growth restriction. Pediatric Research. 50: 641-9.

12. Davey, M.G., Hooper, S.B., Tester, M.L. and Harding, R. (2001).  Stimulation of lung growth in fetuses with lung hypoplasia leads to altered postnatal lung structure in sheep.  Pediatric Pulmonology, 32: 267-276.

13. Lines, A.L., Davey, M.G., Harding, R. and Hooper, S.B. (2001). Effect of increased lung expansion on surfactant protein mRNA levels in lambs. Pediatric Research 50:720-725.

14. Gillet, A.M., Wallace, M.J. Gillespie, M. and Hooper, S.B. (2002). Increased expansion of the lung stimulates calmodulin-2 expression in fetal sheep. American Journal of Physiology 282: L440-L447.

15. Flecknoe, S.J., Wallace, M.J., Harding, R. and Hooper, S.B. (2002). Determination of alveolar epithelial cell phenotypes in fetal sheep: evidence for the involvement of basal lung expansion. Journal of Physiology 542:245-253.

16. Joyce, B.J., Wallace, M.J., Pierce, R.A., Harding, R. and Hooper, S.B. (2003). Sustained changes in lung expansion alter tropoelastin mRNA levels and elastin content in fetal sheep lungs. American Journal of Physiology 284: L643-649.

17. Flecknoe, S., Wallace, M.J., Cock, M.L., Harding, R. and Hooper, S.B. (2003). Changes in alveolar epithelial cell proportions during fetal and postnatal development in sheep. American Journal of Physiology 285: L664-L670.

18. Harding, R., Cock, M.L., Joyce, B.J., Louey,S., Wignarajah, D., Suzuki, K., Albuquerque, C.A., Maritz G., Wallace, M.J. and Hooper, S.B.  (2003). Immediate and long-term consequences of induced low birth weight in sheep. In: Comparative Neonatology and Perinatology, Havemeyer Foundation Monograph Series No. 8. Eds P. Sibbons, L. Foster and J.F. Wade. R&W Publications, UK. 29-31.

19. Liu, H., Hooper, S.B., Armugan, A., Dawson, N., Ferraro, T., Jeyaseelan, K., Thiel, A., Koukoulas, I.and Wintour, E.M. (2003). Aquaporin gene expression and regulation in the ovine fetal lung. Journal of Physiology 551.2: 503-514.

20. Hooper, S.B. and Wallace, M.J. (2003). Physical, endocrine and growth factors in lung development. In: The lung: development, aging and the environment. Eds. R. Harding, K.E. Pinkerton and C.G. Plopper. Elsevier Academic Press, London. Ch.9, pp. 131-148

21. Hooper, S.B. and Harding, R. (2003). Pulmonary transition at birth. In: The lung: development, aging and the environment. Eds. R. Harding, K.E. Pinkerton and C.G. Plopper. Elsevier Academic Press, London. Ch.14, pp. 201-211.

22. Harding, R. and Hooper, S.B. (2004). Physiologic mechanisms of normal and altered lung growth. In: Fetal and Neonatal Physiology, 3^rd Edition. Eds. Polin, Fox & Abman. Harcourt Health Sciences, Philadelphia. Ch.78. pp. 802-811.

23. Probyn, M.E., Hooper, S.B., Dargaville, P.A., McCallion, N., Crossley, K., Harding, R. and Morley, C.J. (2004). Positive end expiratory pressure during resuscitation of premature lambs rapidly improves blood gases without adversely affecting arterial pressure. Pediatric Research 56:198-204.

24. Boland, R., Joyce, B.J., Wallace, M.J., Stanton, H., Fosang, A.J., Pierce, R.A., Harding, R. and Hooper, S.B.  (2004). Cortisol enhances structural maturation of the hypoplastic fetal lung in sheep. Journal of Physiology 554: 505-517.

25. Cole,T.J., Solomon, N.M.,Van Driel, R., Monk, J.A., Bird, D., Richardson, S.J., Dilley, R.J. and Hooper, S.B. (2004).  Altered epithelial cell proportions in the fetal lungs of glucocorticoid receptor null mice. American Journal of Respiratory Cell and Molecular Biology. 30: 613-619

26. CockM.L., Joyce B.J., Hooper, S.B., Wallace, M.J., Gagnon, R., Brace R.A., Louey S. and Harding R. (2004). Pulmonary elastin synthesis and deposition in developing and mature sheep: effects of intra-uterine growth restriction. Experimental Lung Research 30(5): 405-418.

27. Polglase, G.R., Wallace, M.J., Grant, D.A. and Hooper, S.B. Influence of fetal breathing movements on pulmonary haemodynamics in fetal sheep. Pediatric Research. 56:932-938.

28. Flecknoe, S.J., Boland, R.E., Wallace, M.J., Harding, R. and Hooper, S.B. Regulation of alveolar epithelial cell phenotypes in sheep: roles of cortisol and lung expansion. American Journal of Physiology 287: L1207-14.

29. Suzuki, K., Hooper, S.B., Cock, M.L. and Harding, R. (2004). Effect of lung hypoplasia on birth-related changes in the pulmonary circulation in sheep. Pediatric Research (in press).

30. Probyn, M.E, Hooper, S.B., Dargaville, P.A, McCallion, Harding, R., Morley, C.J.Effects of tidal volume and PEEP during resuscitation of very premature lambs. Acta Pediatrica (in press).

31. Cock, M.L., Hanna, M., Sozo F., Wallace, M.J. Yawno, T., Suzuki K., Maritz G., R. Harding and Hooper S.B. Pulmonary function and structure following mild preterm birth in lambs. Pediatric Pulmonology (in press).

32. Hooper, S.B. and Harding, R. (2005) Role of aeration in the physiological adaptation of the lung to air-breathing at birth. Current Respiratory Medicine Reviews (in press).

33. Harding R., Albuquerque, C.A. and Hooper, S.B. Breathing: Fetal Breathing.  In: Encyclopedia of Respiratory Medicine. Eds. G.J. Laurent and S.D. Shapiro. Elsevier, UK.  (in press).

34. Hooper S.B.and R. Harding. Breathing: Fetal lung liquid. In: Encyclopedia of Respiratory Medicine. Eds. G.J. Laurent and S.D. Shapiro. Elsevier, UK. (in press).

35. Harding, R., Wallace M.J., and Hooper S.B.  Lung development: Overview.  In: The Encyclopedia of Respiratory Medicine. (2005). Ed. G. Laurent and S Shapiro. Elsevier Academic Press, London UK. Chapter 221: (in press).

Publications - Dr. Wallace

1. Wallace M.J., Lines A.M, Polglase G.R., and Hooper S.B. IGF-II, PDGF-B, TGF-b₁ and VEGF mRNA levels during increased lung expansion in fetal sheep. Journal of Physiology (submitted April 2002).

2. Hooper S.B. and Wallace, M.J. Role of physical, endocrine and growth factors in lung development. In: The Lung: Development, Aging and the Environment. Ed. R. Harding, K.E. Pinkerton & C.G. Plopper. Academic Press, London. (Submitted July 2002).

3. Joyce B.J., Wallace M.J., Harding R. and Hooper S.B. Alterations in lung expansion affect Tropoelastin mRNA levels in the lungs of fetal sheep. American Journal of Physiology (accepted, pending minor revisions)

4. Flecknoe S.J., Wallace M.J., Harding R. and Hooper S.B. (2002) The phenotype of alveolar epithelial cells is regulated by the degree of lung expansion in fetal sheep. Journal of Physiology 542: 245-253.

5. Gillett A.M., Wallace M.J., Gillespie M.T. and Hooper S.B. (2002) Increased expansion of the lung stimulates calmodulin 2 expression in fetal sheep. American Journal of Physiology. 282: L440-L447.

6. Lines A., Gillett A.M., Phillips I.D., Wallace M.J. and Hooper S.B. (2001) Re-expression of pulmonary surfactant proteins following tracheal obstruction in fetal sheep. Journal of Experimental Physiology. 86: 55-63.

7. Probyn M. E., Wallace M.J. and Hooper S.B. (2000) Effects of increased lung expansion on lung growth and development near midgestation in fetal sheep. Pediatric Research 47: 806-812.

8. Wallace M. J., Batt J., Fladd C. F., Henderson J. T., Skarnes W. C. and Rotin D. (1999) Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTP?. Nature Genetics 21: 334-338.

9. Wallace M. J., Fladd C., Batt J. and Rotin D. (1998) The second catalytic domain of protein tyrosine phosphatase d (PTPd) binds to and inhibits the first catalytic domain of PTPs. Molecular and Cellular Biology 18: 2608-2616.

10. Kim H., Yeger H., Han R., Wallace M., Goldstein B. and Rotin D. (1996) Expression of the tyrosine phosphatase LAR-PTP2 in rat lung is confined to proliferating epithelia lining the airways and air sacs. American Journal of Physiology 270: L566-L576.

11. Wallace M.J., Hooper S.B. and Harding R. (1996) Role of the adrenal glands in the maturation of lung liquid secretory mechanisms in fetal sheep. American Journal of Physiology 270: R33-R40.

12. Wallace M.J., Hooper S.B., McCrabb G.J. and Harding R. (1996) Acidaemia enhances the inhibitory effect of hypoxia on fetal lung liquid secretion in sheep. Reproduction, Fertility and Development 8: 327-333.

13. Jeffray T.M., Berdusco E.T.M., Wallace M., Fowden A.L. and Challis J.R.G. (1995) Effects of incremental cortisol and adrenalectomy (ADX) on plasma corticosteroid binding capacity (CBC) in fetal sheep. Canadian Journal of Physiology and Pharmacology 73: 1568-1573.

14. Wallace M.J., Hooper S.B. and Harding R. (1995) Effects of elevated fetal cortisol concentrations on the volume, secretion and reabsorption of lung liquid. American Journal of Physiology 269: R881-R887.

Publications - Dr. Crossley

1. Crossley K.J., Walker D.W., Beart P.M. and Hirst J.J.
Localisation of neuroactive steroid sensitive GABA_A receptors in the fetal sheep brain. (Submitted to Developmental Brain Research)

2. Characterisation of GABA_A receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone. Neuropharmacology, 39 (9), 1514-1522, 2000.

Crossley K.J, Nicol M.B, Hirst J.J, Walker D.W and Thorburn G.D. Suppression of arousal by progesterone in fetal sheep.
Reproduction, Fertility, & Development, 9: 767-773, 1997.