Fetal & Neonatal Lung Development Laboratory

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Publications - Dr. Hooper

1. Hooper, S.B., Walker, D.W. and Harding, R. (1995). Oxygen, glucose and lactate uptake by the fetus and placenta during prolonged hypoxemia. American Journal of Physiology 268: R303-R309.

2. Hooper, S.B. and Harding, R. (1995). Fetal lung liquid; a major determinant of the growth and functional development of the fetal lung. Clinical and Experimental Pharmacology and Physiology 22: 54-66.

3. Wlodek, M.E., Brace, R.A., Cock, M.L., Hooper, S.B., and Harding, R. (1995). Endocrine responses of fetal sheep to prolonged hypoxemia with and without acidemia: relation to urine production. American Journal of Physiology. 268: F868-F875.

4. Wallace, M.J., Hooper, S.B. and Harding, R. (1995). Effects of elevated fetal cortisol concentrations on the volume, secretion and reabsorption of lung liquid. American Journal of Physiology. 269: R881-R887.

5. Hooper, S.B. (1995). Fetal metabolic responses to hypoxemia. Reproduction, Fertility and Development. 7: 527-538.

6. Nardo, L., Hooper, S.B. and Harding, R. (1995). Lung hypoplasia can be reversed by short term obstruction of the trachea in fetal sheep. Pediatric Research. 38: 690-696.

7. Bocking, A.D., White, S.E., Kent, S. Fraher, L. and Hooper, S.B. (1995). Effect of prolonged catecholamine infusion on heart rate, blood pressure and breathing and growth in fetal sheep. Canadian Journal of Physiology and Pharmacology. 73: 1750-1758.

8. Keramidaris, E., Hooper, S.B. and Harding, R. (1996). Effect of gestational age on the increase in fetal lung growth following tracheal obstruction. Experimental Lung Research. 22: 283-298.

9. Wallace, M.J., Hooper, S.B. and Harding, R. (1996). Role of the adrenal glands in the maturation of lung liquid secretory mechanisms in fetal sheep. American Journal of Physiology. 270: R33-R40.

10. Wallace, M.J., Hooper, S.B., G.J. McCrabb and Harding, R. (1996). Acidaemia enhances the inhibitory effect of hypoxia on fetal lung liquid secretion in sheep. Reproduction Fertility and Development. 8: 327-333.

11. Harding, R. and Hooper, S.B. (1996) Regulation of lung expansion and lung growth before birth. Journal of Applied Physiology 81(1): 209-224.

12. Stratford, L. and Hooper, S.B. (1997). Effect of hypoxemia on tissue glycogen content and glycolytic enzyme activities in fetal sheep. American Journal of Physiology. 272: R103-R110.

13. Lines, A., Hooper, S.B. and Harding R. (1997). Lung liquid production rates and volumes do not decrease before labor in healthy fetal sheep. Journal of Applied Physiology 82: 927-932.

14. Rees, S.M., Stringer, M., Just, Y. Hooper, S.B. and Harding, R. (1997). The vulnerability of the fetal sheep brain to hypoxemia at mid-gestation. Developmental Brain Research 103: 103-118.

15. Boland, R., Nardo, L. and Hooper, S.B. (1997). Cortisol pretreatment enhances the lung growth response to tracheal obstruction in fetal sheep. American Journal of Physiology 273: L1126-L1131.

16. Hooper, S.B. and I.R. Young. (1998). Endocrine maturation of the fetus. In: Endocrinology of pregnancy. Ed. F.W. Bazer. The Humana Press Inc., Totowa, NJ pp353-385

17. Nardo, L., Hooper, S.B., and Harding, R. (1998). Stimulation of lung growth by tracheal obstruction in fetal sheep: relation to luminal pressure and lung liquid volume. Pediatric Research 43: 184-190.

18. Wlodek, M.E., Hooper, S.B. Thorburn, G.D. and Harding, R. (1998). Effects of Prostaglandin E2 on renal function and lung liquid dynamics in foetal sheep. Clinical and Experimental Pharmacology and Physiology 25: 805-812.

19. Hooper, S.B. (1998). Role of luminal volume changes in the increase in pulmonary blood flow at birth in sheep. Experimental Physiology. 83: 833-842.

20. Harding, R. and Hooper, S.B. (1999). Lung development and maturation. In: Fetal Medicine; Basic Science and Clinical Practice. Eds. C.H. Rodek & M. Whittle. Churchill Livingston. London, UK pp.181-196

21. Lines, A., Nardo, L., Phillips, I.D., Possmayer, F. and Hooper, S.B. (1999) Alterations in lung expansion affect surfactant protein A, B and C mRNA levels in fetal sheep. American Journal of Physiology. 276: L239-L245.

22. Davey, M.G., Hooper, S.B., Tester, M.L., Johns, D.P. and Harding, R. (1999). Respiratory function in lambs after in utero treatment of lung hypoplasia by tracheal obstruction. Journal of Applied Physiology 87: 2296-2304.

23. Harding, R., Tester, M.L., Moss, T.J., Davey, M.G., Louey, S., Joyce, B. Hooper, S.B. and Maritz, G. (2000). Effects of intra-uterine growth restriction on the control of breathing and lung development after birth. Clinical and Experimental Pharmacology and Physiology 27: 114-119.

24. Nardo, L., Maritz, G., Harding, R and Hooper, S.B. (2000) Changes in lung structure and cellular division induced by tracheal obstruction in fetal sheep. Experimental Lung Research 26(2): 105-119.

25. Harding, R., Cock, M.L., Louey, S., Joyce, B.J., Davey, M.G., Albuquerque, C.A., Hooper, S.B. and Maritz, G.S. (2000). The compromised intra-uterine environment: implications for future lung health. Clinical and Experimental Pharmacology and Physiology 27:965-974.

26. Nardo, L., Young, I.R. and Hooper, S.B. (2000). Influence of growth hormone on the lung growth response to tracheal obstruction in fetal sheep. American Journal of Physiology 278:L453-L459.

27. Flecknoe, S., Harding, R., Maritz,G. and Hooper, S.B. (2000). Increased lung expansion alters the proportions of Type-I and Type-II alveolar epithelial cells in fetal sheep. American Journal of Physiology 278: L1180-L1187.

28. Probyn, M., Wallace, M.J. and Hooper, S.B. (2000). Effect of increased lung expansion on lung growth and development near mid-gestation in fetal sheep. Pediatric Research. 47:806-812

29. Hooper, S.B. and Harding R. (2001) Respiratory System. In: Textbook of Fetal Development. Eds. R. Harding & A.D. Bocking. Cambridge University Press Ch 6. pp. 114-136.

30. Cock, M.L., Albuqerque, C.A., Joyce, B.J., Hooper, S.B. and Harding, R. (2001). Effects of Intrauterine growth restriction on lung liquid dynamics and lung development in fetal sheep. American Journal of Obstetrics and Gynecology. 184:209-216

31. Lines, A., Gillett, A. Wallace, M.J., Phillips, I.D. and S.B. Hooper. (2001) Re-expression of pulmonary surfactant proteins following tracheal obstruction in fetal sheep. Experimental Physiology. 86:55-63

32. Jenkin, G., Ward, J., Hooper, S.B., O=Connor, A. de Kretser, D. and Wallace, E. (2001). Feto-placental hypoxemia regulates the release of fetal activin A and prostaglandin E2. Endocrinology 142:963-966.

33. Joyce, B.J., Louey, S., Davey, M.G., Cock, M.L., Hooper, S.B. and Harding, R. (2001). Compromised respiratory function in postnatal lambs after placental insufficiency and intrauterine growth restriction. Pediatric Research. 50: 641-9.

34. Davey, M.G., Hooper, S.B., Tester, M.L. and Harding, R. (2001). Stimulation of lung growth in fetuses with lung hypoplasia leads to altered postnatal lung structure in sheep. Pediatric Pulmonology, 32: 267-276

35. Lines, A., Davey, M.G., Harding, R. and Hooper, S.B. (2001). Effect of increased lung expansion on surfactant protein mRNA levels in lambs. Pediatric Research 50:720-725

36. Gillet, A., Wallace, M.J. Gillespie, M. and Hooper, S.B. (2002). Increased lung expansion stimulates calmodulin-2 expression in fetal sheep. American Journal of Physiology 282: L440-L447.

37. Flecknoe, S., Wallace, M.J., Harding, R. and Hooper, S.B. (2002). Determination of alveolar epithelial cell phenotypes in fetal sheep: evidence for the involvement of basal lung expansion. Journal of Physiology 542:245-253.

38. Joyce, B.J., Wallace, M.J., Harding, R. And Hooper, S.B. Alterations in lung expansion affect tropoelastin mRNA levels in the lungs of fetal sheep. American Journal of Physiology (submitted, March, 2002)

39. Wallace, M.J., Lines, A., Polglase, G.R. and Hooper, S.B. Changes in IGF-II, PDGF-B, TGF-ß1 and VEGF mRNA levels in response to increases in lung expansion in fetal sheep. Journal of Physiology (submitted April, 2002).

40. Flecknoe, S., Wallace, M.J., Cock, M.L., Harding, R. and Hooper, S.B. Changes in alveolar epithelial cell proportions during late gestation and after birth in sheep. American Journal of Physiology (submitted July, 2002).

41. Hooper, S.B. and Wallace, M.J. Role of physical, endocine and growth factors in lung development. In: The lung: development, aging and the environment. Eds. R. Harding, K. Pinkerton and C. Plopper. Academic Press, Cambridge.

42. Hooper, S.B. and Harding, R. Pulmonary transition at birth. In: The lung: development, aging and the environment. Eds. R. Harding, K. Pinkerton and C. Plopper. Academic Press, Cambridge.

Publications - Dr. Wallace

1. Wallace M.J., Lines A.M, Polglase G.R., and Hooper S.B. IGF-II, PDGF-B, TGF-b₁ and VEGF mRNA levels during increased lung expansion in fetal sheep. Journal of Physiology (submitted April 2002).

2. Hooper S.B. and Wallace, M.J. Role of physical, endocrine and growth factors in lung development. In: The Lung: Development, Aging and the Environment. Ed. R. Harding, K.E. Pinkerton & C.G. Plopper. Academic Press, London. (Submitted July 2002).

3. Joyce B.J., Wallace M.J., Harding R. and Hooper S.B. Alterations in lung expansion affect Tropoelastin mRNA levels in the lungs of fetal sheep. American Journal of Physiology (accepted, pending minor revisions)

4. Flecknoe S.J., Wallace M.J., Harding R. and Hooper S.B. (2002) The phenotype of alveolar epithelial cells is regulated by the degree of lung expansion in fetal sheep. Journal of Physiology 542: 245-253.

5. Gillett A.M., Wallace M.J., Gillespie M.T. and Hooper S.B. (2002) Increased expansion of the lung stimulates calmodulin 2 expression in fetal sheep. American Journal of Physiology. 282: L440-L447.

6. Lines A., Gillett A.M., Phillips I.D., Wallace M.J. and Hooper S.B. (2001) Re-expression of pulmonary surfactant proteins following tracheal obstruction in fetal sheep. Journal of Experimental Physiology. 86: 55-63.

7. Probyn M. E., Wallace M.J. and Hooper S.B. (2000) Effects of increased lung expansion on lung growth and development near midgestation in fetal sheep. Pediatric Research 47: 806-812.

8. Wallace M. J., Batt J., Fladd C. F., Henderson J. T., Skarnes W. C. and Rotin D. (1999) Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTP?. Nature Genetics 21: 334-338.

9. Wallace M. J., Fladd C., Batt J. and Rotin D. (1998) The second catalytic domain of protein tyrosine phosphatase d (PTPd) binds to and inhibits the first catalytic domain of PTPs. Molecular and Cellular Biology 18: 2608-2616.

10. Kim H., Yeger H., Han R., Wallace M., Goldstein B. and Rotin D. (1996) Expression of the tyrosine phosphatase LAR-PTP2 in rat lung is confined to proliferating epithelia lining the airways and air sacs. American Journal of Physiology 270: L566-L576.

11. Wallace M.J., Hooper S.B. and Harding R. (1996) Role of the adrenal glands in the maturation of lung liquid secretory mechanisms in fetal sheep. American Journal of Physiology 270: R33-R40.

12. Wallace M.J., Hooper S.B., McCrabb G.J. and Harding R. (1996) Acidaemia enhances the inhibitory effect of hypoxia on fetal lung liquid secretion in sheep. Reproduction, Fertility and Development 8: 327-333.

13. Jeffray T.M., Berdusco E.T.M., Wallace M., Fowden A.L. and Challis J.R.G. (1995) Effects of incremental cortisol and adrenalectomy (ADX) on plasma corticosteroid binding capacity (CBC) in fetal sheep. Canadian Journal of Physiology and Pharmacology 73: 1568-1573.

14. Wallace M.J., Hooper S.B. and Harding R. (1995) Effects of elevated fetal cortisol concentrations on the volume, secretion and reabsorption of lung liquid. American Journal of Physiology 269: R881-R887.

Publications - Dr. Crossley

1. Crossley K.J., Walker D.W., Beart P.M. and Hirst J.J.
Localisation of neuroactive steroid sensitive GABA_A receptors in the fetal sheep brain. (Submitted to Developmental Brain Research)

2. Characterisation of GABA_A receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone. Neuropharmacology, 39 (9), 1514-1522, 2000.

Crossley K.J, Nicol M.B, Hirst J.J, Walker D.W and Thorburn G.D. Suppression of arousal by progesterone in fetal sheep.
Reproduction, Fertility, & Development, 9: 767-773, 1997.