Michael de Veer
Project Leader - Innate Immunity Laboratory
Email: michael.deveer@med.monash.edu.au
Phone: +61 3 990 55132
Fax: +61 3 990 52547
Background information
Dr de Veer completed his PhD at the Monash University Department of Biochemistry & Molecular Biology in 1998. Following this he moved to Cleveland, Ohio, USA to pursue post doctoral studies at the Lerner Research Institute. Here he studied cytokine biology and innate immune signaling with an emphasis on Toll Like Receptors. Dr de Veer also investigated RNA-interference and RNA signaling, two areas he remains active in today. Following his 3 years in Cleveland he obtained an NHMRC-Howard Florey Fellowship to return to the Walter and Eliza Hall Institute, Parkville, Australia where investigated how malaria activates the innate immune system.This ignited his interest in parasites and how they stimulate the immune system, an interest he is developing within the BRL.
His current research interests include:
- How different vaccines adjuvants stimulate the innate immune system.
- How the innate immune system modulates adaptive immunity.
- What innate response leads to allergy.
For a selection of student projects with Dr de Veer please click here
Selected Publications:
- de Veer M. J., Kemp J, Chatelier J, Elhay MJ, Meeusen EN. (2011). Modulation of soluble and particulate antigen transport in afferent lymph by monophosphoryl lipid A. Immunology and Cell Biology (In Press).
- de Veer M. J., Kemp J, Chatelier J, Elhay MJ, Meeusen EN. (2010). The kinetics of soluble and particulate antigen trafficking in the afferent lymph, and its modulation by aluminum-based adjuvant. Vaccine. 2010 28(40):6597-602.
- de Veer M. J., Kemp, J. M., Meeusen E.N.T. (2007) The innate immune response to nematode parasites. Parasite Immunol. 29: 1-9.
- Zawadski J. L., Presidente P. J. A., Meeusen E. N. T. and de Veer M. J. (2006). RNAi in Haemonchus contortus: a potential method for target validation. Trends in Parasitology 22(11): 495-9.
- Nebl, T., M. J. de Veer, and L. Schofield. (2005). Stimulation of innate immune responses by malarial glycosylphosphatidylinositol via pattern recognition receptors. Parasitology 130 Suppl:S45.
- de Veer, M. J., C. A. Sledz, and B. R. Williams. (2005). Detection of foreign RNA: implications for RNAi. Immunol Cell Biol 83:224.
- Whitmore, M. M., M. J. de Veer, A. Edling, R. K. Oates, B. Simons, D. Lindner, and B. R. Williams. (2004). Synergistic activation of innate immunity by double-stranded RNA and CpG DNA promotes enhanced antitumor activity. Cancer Res 64:5850.
- Sledz, C. A., M. Holko, M. J. de Veer, R. H. Silverman, and B. R. Williams. (2003). Activation of the interferon system by short-interfering RNAs. Nat Cell Biol 5:834.
- Leitner, W. W., L. N. Hwang, M. J. deVeer, A. Zhou, R. H. Silverman, B. R. Williams, T. W. Dubensky, H. Ying, and N. P. Restifo. (2003). Alphavirus-based DNA vaccine breaks immunological tolerance by activating innate antiviral pathways. Nat Med 9:33.
- de Veer, M. J., J. M. Curtis, T. M. Baldwin, J. A. DiDonato, A. Sexton, M. J. McConville, E. Handman, and L. Schofield. (2003). MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling. Eur J Immunol 33:2822.
- de Veer, M. J., M. Holko, M. Frevel, E. Walker, S. Der, J. M. Paranjape, R. H. Silverman, and B. R. Williams. (2001). Functional classification of interferon-stimulated genes identified using microarrays. J Leukoc Biol 69:912.
- Goh, K. C., M. J. deVeer, and B. R. Williams. (2000). The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J 19:4292.
