Associate Professor Grant Drummond

Current Position

NH&MRC Career Development Award Fellow

Address

Department of Pharmacology
Monash University
Clayton, Victoria, 3800  Australia

Email: grant.drummond@monash.edu
Phone:  +61 3 9905 4869
Facsimile:  (03) 9902 9500

Grant Drummond received his PhD from the Department of Pharmacology, University of Melbourne in 1998 and then completed 2 years of postdoctoral training in Atlanta, USA on an American Heart Association Postdoctoral Fellowship. It was while working in the USA that Grant developed his interest in NADPH oxidases and reactive oxygen species as mediators of redox signaling and oxidative stress in vascular physiology and pathophysiology, respectively.

Grant returned to Australia in 2000 on a Peter Doherty Postdoctoral fellowship and spent 4 years working at the Howard Florey Institute with Prof Greg Dusting. He moved to Monash University on a Logan Fellowship in 2004 where he is now an NHMRC RD Wright Research Fellow and co-leader of the Vascular Biology and Immunopharmacology Group in the Department of Pharmacology.

Grant's work has shown that NADPH oxidases are the major source of elevated superoxide in the vasculature during conditions such as hypertension and hypercholesterolemia, and thus important contributors to early atherogenic changes in the vessel wall including oxidative stress, nitric oxide inactivation and vascular inflammation. Grant is now actively engaged in trying to identify novel, isoform selective inhibitors of NADPH oxidases as leads for the development of new cardiovascular therapeutics.

Journal Publications (since 2005)

Rivera J, Sobey CG, Walduck AK, Drummond GR. Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models. Redox Rep, 15(2):50-63, 2010. PubMed PMID: 20500986.

Miller AA, De Silva TM, Judkins CP, Diep H, Drummond GR, Sobey CG. Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. Stroke, 41(4):784-9, 2010. PubMed PMID: 20167907.

Brait VH, Jackman KA, Walduck AK, Selemidis S, Diep H, Mast AE, Guida E, Broughton BR, Drummond GR, Sobey CG. Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide. J Cereb Blood Flow Metab, 2010 Feb 10. [Epub ahead of print] PubMed PMID: 20145655.

Harrison CB, Drummond GR, Sobey CG, Selemidis S. Evidence that nitric oxide inhibits vascular inflammation and superoxide production via a p47phox-dependent mechanism in mice. Clin Exp Pharmacol Physiol, 37(4):429-34, 2010. PubMed PMID: 19843095.

Judkins CP, Diep H, Broughton BR, Mast AE, Hooker EU, Miller AA, Selemidis S, Dusting GJ, Sobey CG, Drummond GR. Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice. Am J Physiol Heart Circ Physiol, 298(1):H24-32, 2010. PubMed PMID: 19837950.

Jackman KA, Miller AA, Drummond GR, Sobey CG. Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke. Brain Res, 1286:215-20, 2009. PubMed PMID: 19559686.

Peshavariya H, Dusting GJ, Jiang F, Halmos LR, Sobey CG, Drummond GR, Selemidis S. NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival. Naunyn Schmiedebergs Arch Pharmacol, 380(2):193-204, 2009. PubMed PMID: 19337723.

De Silva TM, Broughton BR, Drummond GR, Sobey CG, Miller AA. Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species. Stroke, 40(4):1091-7, 2009. PubMed PMID:19211495.

Jackman KA, Miller AA, De Silva TM, Crack PJ, Drummond GR, Sobey CG. Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2-deficient mice. Br J Pharmacol, 156(4):680-8, 2009. PubMed PMID: 19175604.

Miller AA, Drummond GR, De Silva TM, Mast AE, Hickey H, Williams JP, Broughton BR, Sobey CG. NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2. Am J Physiol Heart Circ Physiol, 296(1):H220-5, 2009. PubMed PMID: 19028794.

Selemidis S, Sobey CG, Wingler K, Schmidt HH, Drummond GR. NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition. Pharmacol Ther, 120(3):254-91, 2008. Review. PubMed PMID: 18804121.

Thomas SR, Witting PK, Drummond GR. Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal, 10(10):1713-65, 2008. Review. PubMed PMID: 18707220.

Drummond GR, Selemidis S, Cocks TM. B2 kinin receptor activation is the predominant mechanism by which trypsin mediates endothelium-dependent relaxation in bovine coronary arteries. Naunyn Schmiedebergs Arch Pharmacol, 378(1):33-41, 2008. PubMed PMID: 18458878.

Mantena RK, Wijburg OL, Vindurampulle C, Bennett-Wood VR, Walduck A, Drummond GR, Davies JK, Robins-Browne RM, Strugnell RA. Reactive oxygen species are the major antibacterials against Salmonella Typhimurium purine auxotrophs in the phagosome of RAW 264.7 cells. Cell Microbiol, 10(5):1058-73, 2008. PubMed PMID: 18067606.

Vinh A, Widdop RE, Drummond GR, Gaspari TA. Chronic angiotensin IV treatment reverses endothelial dysfunction in ApoE-deficient mice. Cardiovasc Res, 77(1):178-87, 2008. PubMed PMID: 18006471.

Chan EC, Datla SR, Dilley R, Hickey H, Drummond GR, Dusting GJ. Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits. Cardiovasc Res, 75(4):710-8, 2007. PubMed PMID: 17659266.

Selemidis S, Dusting GJ, Peshavariya H, Kemp-Harper BK, Drummond GR. Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells. Cardiovasc Res, 75(2):349-58, 2007. PubMed PMID: 17568572.

Miller AA, Drummond GR, Mast AE, Schmidt HH, Sobey CG. Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen. Stroke, 38(7):2142-9, 2007. PubMed PMID: 17525399.

Ritchie RH, Quinn JM, Cao AH, Drummond GR, Kaye DM, Favaloro JM, Proietto J, Delbridge LM. The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo. J Mol Cell Cardiol, 42(6):1119-28, 2007. PubMed PMID: 17490678.

Opitz N, Drummond GR, Selemidis S, Meurer S, Schmidt HH. The 'A's and 'O's of NADPH oxidase regulation: a commentary on "Subcellular localization and function of alternatively spliced Noxo1 isoforms". Free Radic Biol Med, 42(2):175-9, 2007. Review. PubMed PMID: 17189823.

Lob H, Rosenkranz AC, Breitenbach T, Berkels R, Drummond G, Roesen R. Antioxidant and nitric oxide-sparing actions of dihydropyridines and ACE inhibitors differ in human endothelial cells. Pharmacology, 76(1):8-18, 2006. PubMed PMID: 16220025.

Miller AA, Drummond GR, Sobey CG. Reactive oxygen species in the cerebral circulation: are they all bad? Antioxid Redox Signal, 8(7-8):1113-20, 2006. Review. PubMed PMID: 16910759.

Laskowski A, Woodman OL, Cao AH, Drummond GR, Marshall T, Kaye DM, Ritchie RH. Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes. Cardiovasc Res, 72(1):112-23, 2006. PubMed PMID: 16890211.

Miller AA, Drummond GR, Sobey CG. Novel isoforms of NADPH-oxidase in cerebral vascular control. Pharmacol Ther, 111(3):928-48, 2006. Review. PubMed PMID: 16616784.

Judkins CP, Sobey CG, Dang TT, Miller AA, Dusting GJ, Drummond GR. NADPH-induced contractions of mouse aorta do not involve NADPH oxidase: a role for P2X receptors. J Pharmacol Exp Ther, 317(2):644-50, 2006. PubMed PMID: 16407465.

Paravicini TM, Miller AA, Drummond GR, Sobey CG. Flow-induced cerebral vasodilatation in vivo involves activation of phosphatidylinositol-3 kinase, NADPH-oxidase, and nitric oxide synthase. J Cereb Blood Flow Metab, 26(6):836-45, 2006. PubMed PMID: 16222243.

Miller AA, Drummond GR, Schmidt HH, Sobey CG. NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circ Res, 97(10):1055-62, 2005. PubMed PMID: 16210546.

Kairuz EM, Barber MN, Anderson CR, Kanagasundaram M, Drummond GR, Woods RL. C-type natriuretic peptide (CNP) suppresses plasminogen activator inhibitor-1 (PAI-1) in vivo. Cardiovasc Res, 66(3):574-82, 2005. PubMed PMID: 15914122.

Nicholls SJ, Dusting GJ, Cutri B, Bao S, Drummond GR, Rye KA, Barter PJ. Reconstituted high-density lipoproteins inhibit the acute pro-oxidant and proinflammatory vascular changes induced by a periarterial collar in normocholesterolemic rabbits. Circulation, 111(12):1543-50, 2005. PubMed PMID: 15781735.

Ellmark SH, Dusting GJ, Fui MN, Guzzo-Pernell N, Drummond GR. The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle. Cardiovasc Res, 65(2):495-504, 2005. PubMed PMID: 15639489.