PHARMACOLOGY RESEARCH PUBLICATIONS at 16-7-2007

Mittal, M., Roth, M., Konig, P., Hofmann, S., Dony, E., Goyal, P., Selbitz, A.C., Schermuly, R.T., Ghofrani, H.A., Kwapiszewska, G., Kummer, W., Klepetko, W., Hoda, M.A., Fink, L., Hanze, J., Seeger, W., Grimminger, F., Schmidt, H.H., and Weissmann, N., Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature. Circ Res, 2007. E-Pub. Impact Factor: 9.854

Bisson, W.H., Cheltsov, A.V., Bruey-Sedano, N., Lin, B., Chen, J., Goldberger, N., May, L.T., Christopoulos, A.,Dalton, J.T., Sexton, P.M., Zhang, X.K., and Abagyan, R., Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs. Proc Natl Acad Sci U S A, 2007. E-Pub. Impact Factor: 9.643

Widder, J.D., Guzik, T.J., Mueller, C.F., Clempus, R.E., Schmidt, H.H., Dikalov, S.I., Griendling, K.K., Jones, D.P., and Harrison, D.G., Role of the Multidrug Resistance Protein-1 in Hypertension and Vascular Dysfunction Caused by Angiotensin II. Arterioscler Thromb Vasc Biol, 2007. 27(4): p. 762-768. Impact Factor: 6.883

Scheele, C., Nielsen, A.R., Walden, T.B., Sewell, D.A., Fischer, C.P., Brogan, R.J., Petrovic, N., Larsson, O., Tesch, P.A., Wennmalm, K., Hutchinson, D.S., Cannon, B., Wahlestedt, C., Pedersen, B.K., and Timmons, J.A., Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration? Faseb J, 2007. E-Pub. Impact Factor: 6.721

Irvine, J.C., Favaloro, J.L., Widdop, R.E., and Kemp-Harper, B.K., Nitroxyl Anion Donor, Angeli's Salt, Does Not Develop Tolerance in Rat Isolated Aortae. Hypertension, 2007. 49(4): p. 885-892. Impact Factor: 6.007

Selemidis, S., Dusting, G.J., Peshavariya, H., Kemp-Harper, B.K., and Drummond, G.R., Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells. Cardiovasc Res, 2007. 75(2): p. 349-358. Impact Factor: 5.826

Villar, I.C., Panayiotou, C.M., Sheraz, A., Madhani, M., Scotland, R.S., Nobles, M., Kemp-Harper, B., Ahluwalia, A., and Hobbs, A.J., Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. Cardiovasc Res, 2007. 74(3): p. 515-25. Impact Factor: 5.826

Avlani, V.A., Gregory, K.J., Morton, C.J., Parker, M.W., Sexton, P.M., and Christopoulos, A., Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands. J Biol Chem, 2007. E-Pub. Impact Factor: 5.808

Miller, A.A., Drummond, G.R., Mast, A.E., Schmidt, H.H., and Sobey, C.G., Effect of Gender on NADPH-Oxidase Activity, Expression, and Function in the Cerebral Circulation. Role of Estrogen. Stroke, 2007. 38(7): p. 2142-2149. Impact Factor: 5.391

Moore, X.L., Tan, S.L., Lo, C.Y., Fang, L., Su, Y.D., Gao, X.M., Woodcock, E.A., Summers, R.J., Tregear, G.W., Bathgate, R.A., and Du, X.J., Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes. Endocrinology, 2007. 148(4): p. 1582-1589. Impact Factor: 5.236

Hutchinson, D.S., Csikasz, R.I., Yamamoto, D.L., Shabalina, I.G., Wikstrom, P., Wilcke, M., and Bengtsson, T., Diphenylene iodonium stimulates glucose uptake in skeletal muscle cells through mitochondrial complex I inhibition and activation of AMP-activated protein kinase. Cell Signal, 2007. E-Pub. Impact Factor: 4.887

Ritchie, R.H., Quinn, J.M., Cao, A.H., Drummond, G.R., Kaye, D.M., Favaloro, J.M., Proietto, J., and Delbridge, L.M., The antioxidant tempol inhibits cardiac hypertrophy in the insulin-resistant GLUT4-deficient mouse in vivo. J Mol Cell Cardiol, 2007. 42(6): p. 1119-1128. Impact Factor: 4.859

Dong, M., Lam, P.C., Gao, F., Hosohata, K., Pinon, D.I., Sexton, P.M., Abagyan, R., and Miller, L.J., Molecular Approximations Between Residues 21 and 23 of Secretin and Its Receptor. Development of a Model for Peptide Docking with the Amino Terminus of the Secretin Receptor. Mol Pharmacol, 2007. E-Pub. Impact Factor: 4.469

May, L.T., Avlani, V.A., Langmead, C.J., Herdon, H.J., Wood, M.J., Sexton, P.M., and Christopoulos, A., Structure-Function Studies of Allosteric Agonism at M2 Muscarinic Acetylcholine Receptors. Mol Pharmacol, 2007. E-Pub. Impact Factor: 4.469

Van der Westhuizen, E.T., Werry, T.D., Sexton, P.M., and Summers, R.J., The Relaxin Family Peptide Receptor 3 (RXFP3) activates ERK1/2 through a PKC dependent mechanism. Mol Pharmacol, 2007. 71(6): p. 1618-1629. Impact Factor: 4.469

Van Der Westhuizen, E.T., Summers, R.J., Halls, M.L., Bathgate, R.A., and Sexton, P.M., Relaxin receptors--new drug targets for multiple disease states. Curr Drug Targets, 2007. 8(1): p. 91-104. Impact Factor: 4.274

Small, D.H., Maksel, D., Kerr, M.L., Ng, J., Hou, X., Chu, C., Mehrani, H., Unabia, S., Azari, M.F., Loiacono, R., Aguilar, M.I., and Chebib, M., The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor. J Neurochem, 2007. E-Pub. Impact Factor: 4.260

Hodgson, W.C., Dal Belo, C.A., and Rowan, E.G., The neuromuscular activity of paradoxin: A presynaptic neurotoxin from the venom of the inland taipan (Oxyuranus microlepidotus). Neuropharmacology, 2007. 52(5): p. 1229-1236. Impact Factor: 3.860

Halls, M.L., van der Westhuizen, E.T., Bathgate, R.A., and Summers, R.J., Relaxin Family Peptide Receptors - former orphans reunite with their parent ligands to activate multiple signalling pathways. Br J Pharmacol, 2007. 150(6): p. 677-691. Impact Factor: 3.825

Fitzgerald, S.M., Kemp-Harper, B.K., Parkington, H.C., Head, G.A., and Evans, R.G., Endothelial dysfunction and arterial pressure regulation during early diabetes in mice: roles for nitric oxide and endothelium-derived hyperpolarizing factor. Am J Physiol Regul Integr Comp Physiol, 2007. E-Pub. Impact Factor: 3.685

Chong, Y., Hayes, J., Sollod, B., S., W., Wilson, D., Hains, P., Hodgson, W.C., Broady, K., King, G., and Nicholson, G., The {omega}-atracotoxins: selective blockers of insect M-LVA and HVA calcium channels. Bioch Pharm, 2007. 74(4): p. 623-638. Impact Factor: 3.581

Furness, S.G., Lees, M.J., and Whitelaw, M.L., The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Lett, 2007. E-Pub. Impact Factor: 3.372

Selemidis, S. and Cocks, T., Smooth muscle mediates circumferential conduction of hyperpolarization and relaxation to focal endothelial cell activation in large coronary arteries. Naunyn Schmiedebergs Arch Pharmacol, 2007. 375(2): p. 85-94. Impact Factor: 2.779

Peshavariya, H.M., Dusting, G.J., and Selemidis, S., Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase. Free Radic Res, 2007. 41(6): p. 699-712. Impact Factor: 2.536

Moloney, G.P., Angus, J.A., Robertson, A.D., Stoermer, M.J., Robinson, M., Wright, C.E., McRae, K., and Christopoulos, A., Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB(1) receptor. Eur J Med Chem, 2007. E-Pub. Impact Factor: 2.187