Dr Daniel Layton, BSc(Hons), Ph.D

Immune regeneration lab

Research specialities and project summary

Research specialties include studies into allo and xeno transplantation tolerance induction through bone marrow transplantation and mixed chimerism. These include studies into dendritic cells and hematopoietic stem cells and agents and therapies to reduce myeloablative conditioning. My research interest also includes the development of monoclonal antibodies for diagnostic and therapeutic purposes.

Publications

Refereed journals
Layton, D. S, Bean, A. G., Dodge, N. M., Strom, A. D., Sandrin, M. S. Ierino F. L. (2008). Differential cytokine expression and regulation of human anti-pig xenogeneic responses by modified porcine dendritic cells. Xenotransplantation. 15: 257-267.

Barnard A, Layton D, Hince M, Sakkal S, Bernard C, Chidgey A, Boyd R. L. (2008). Impact of the neuroendocrine system on thymus and bone marrow function. Neuroimmunomodulation. 15: 7-18.

Chidgey, A.P., Layton, D., Trounson, A. Boyd, R. L. (2008). Tolerance strategies for stem-cell-based therapies. Nature. 453: 330-337.

Seach, N., Layton, D., Lim, J., Chidgey, A. Boyd, R. (2007). Thymic generation and regeneration: a new paradigm for establishing clinical tolerance of stem cell-based therapies. Curr. Opin. Biotechnol. 18: 441-447.

Layton, D. S., Strom, A.D., O'Neil, T. E., Broadway, M. M., Stephenson, G. L., Morris, K. R., Muralitharan, M., Sandrin, M. S., Ierino, F.L. and Bean, A. G. (2007). Development of an anti-porcine CD34 monoclonal antibody that identifies hematopoietic stem cells. Exp. Hematol. 35: 171-178.