Dr Andrew Holland, BSc(Hons), Ph.D

Embryonic stem cell differentiation lab

Research Interests

Dr Holland has worked in the pancreas/diabetes field since 1997.  His major interests are in understanding the molecular processes underlying the normal development of the pancreas, with the ultimate aim of directing the differentiation of embryonic stem cells into functional insulin-producing beta cells for use in the treatment of diabetes.

Select Publications

Refereed journals
Holland, A. M., Elefanty, A. G. Stanley, E. G. (2009). Pancreatic differentiation from pluripotent stem cells: tweaking the system. Cell Res. 19: 395-396.

Davis, R., Costa, M., Grandela, C., Holland, A., Hatzistavrou, T., Micallef, S., Li, X., Goulburn, A., Azzola, L., Elefanty, A. Stanley, E. (2008).  A protocol for removal of antibiotic resistance cassettes from human embryonic stem cells genetically modified by homologous recombination or transgenesis. Nat. Protocols. 3: 1550-1558.

Holland, A. M., Micallef, S., Li, X., Elefanty, A. Stanley, E. (2006).  A mouse carrying the green fluorescent protein gene targeted to the Pdx1 locus facilitates the study of pancreas development and function. Genesis. 44: 304-307.

Hale, M. A., Kagami, H., Shi, L., Holland, A. M., Elsasser, H. P., Hammer, R. E. MacDonald, R. J. (2005). The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas. Dev. Biol. 286: 225-237.

Holland, A. M., Gonez, L. J., Naselli, G., MacDonald, R. J. and Harrison, L. (2005). Conditional Expression Demonstrates the Role of the Homeodomain Transcription Factor Pdx1 in Maintenance and Regeneration of Beta-Cells in the Adult Pancreas. Diabetes. 54: 2586-2595.

Holland, A. M., Gonez, L. J. Harrison, L. (2004). Progenitor cells in the adult pancreas. Diabetes Metab. Res. Rev. 20: 13-27.

Holland, A. M., Hale, M. A., Kagami, H., Hammer, R. E. MacDonald, R. J. (2002). Experimental control of pancreatic development and maintenance. Proc. Natl. Acad. Sci. U S A. 99: 12236-12241.