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Neurodegeneration and Regeneration Group
Professor Zhicheng Xiao
Group Leader
Postal
Monash Immunology and Stem Cell
Laboratories (MISCL)
STRIP1, Level 3
Monash University
Clayton 3800
Lab members
Dr Runzhe Shu
PhD Students - MISCL/Kunming Medical College
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Fenlang Zhang
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Li Wen
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Liang Chen
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Lujun Yang
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Ting Hua Wang
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Weiyan Hu
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Zhang Fang
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Zhigang Zhang
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Zhilong Kang
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Zhiyong He
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Research Overview
Appropriate connections or interactions among different neural cell types are essential for the correct and efficient functioning of the nervous system during development and regeneration after trauma or degeneration. The aim of my research is to understand the molecular events that mediate communication among neural cells in the nervous system during development, myelination, learning and memory, degeneration, and regeneration. These studies have yielded insights into the therapeutic potential of cell signalling molecules to ameliorate or even ablate the detrimental consequences of nervous system injury and neurodegenerative diseases, including stroke, traumatic brain injury, spinal cord injury, Alzheimer Disease (AD), and Multiple Sclerosis (MS).
Relevant Publications
H. Ye, T. Zhao, Y.L. Tan, J. Liu, C.J. Pallen, Z.C. Xiao. (2011) Receptor-like protein- tyrosine phosphatase {alpha} enhances cell surface expression of neural adhesion molecule NB-3. J Biol Chem. 286(29):26071-80.
Y.H. Zhu, L. Li, O.N. Demidov, D.V. Bulavin, and Z.C. Xiao (2009) Wip1 regulates the generation of new neural cells in adult olfactory bulb through p53 dependent cell cycle control, Stem Cells 27, 1433 - 1442.
S. Sajikumar, Q. Li, W.C. Abraham and Z.C. Xiao (2009) Priming of short-term potentiation and synaptic tagging by ryanodine receptor activation in rat hippocampal CA1. Learning and Memory 16, 178-186.
Q.H. Ma, T. Futagawa, W.L.Yang, X.D. Jiang, L. Zeng, Y. Takeda, R.X. Xu, D. Bagnard, M. Schachner, A.J. Furley, D. Karagogeos, K. Watanabe, G.S. Dawe, and Z.C. Xiao (2008) A TAG-1/APP signaling pathway through Fe65 negatively modulates neurogenesis. Nature Cell Biology 10, 283-294 (cover story).
H.H. Ye, Y.L.J. Tan, S. Ponniah, Y. Takeda, S.Q. Wang, M. Schachner, K. Watanabe, C.J. Pallen, and Z.C. Xiao (2008) PTPα Mediates Neural Recognition Molecules CHL1 and NB-3-Regulated Apical Dendrite Orientation in the Neocortex. EMBO J. 27, 188-200.
L. Lu, X. Chen, C.W. Zhang, W.L. Yang, Y.J. Wu, L. Sun, L.M. Bai, X.S. Gu, S. Ahmed, G.S. Dawe, and Z.C. Xiao (2008) Morphological and Functional Characterization of Predifferentiation of Oligodendrocyte-Like Cells from Human Bone Marrow Stromal Cells through Activation of F3/Notch Signaling in Mouse Retina. Stem Cells 26, 580-590.
X.W. Tan, H. Liao, L. Sun, M. Okabe, Z.C. Xiao, G. S. Dawe (2005) Fetal microchimerism in the maternal mouse brain: A novel population of fetal progenitor or stem cells able to cross the blood-brain barrier? Stem Cells 23, 1443-1452.
X.Y. Cui, Q.D. Hu, M. Tekaya, Y. Shimoda, B.T. Ang, D.Y. Nie, L. Sun, W.P. Hu, M. Karsak, T. Duka, Y. Takeda, L.Y. Ou, G.S. Dawe, F.G. Yu, S. Ahmed, L.H. Jin, M. Schachner, K. Watanabe, Y. Arsenijevic, and Z.C. Xiao (2004) NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes. J Biol Chem. 279, 25858-25865.
D.Y. Nie, Z.H. Zhou, B.T. Ang, F.H. Teng, G. Xu, T. Xiang, C.Y. Wang, L. Zeng, Y. Takeda, T.L. Xu, Y.K. Ng, C. Faivre-Sarrailh, B. Popko, E.A. Ling, M. Schachner, K. Watanabe, C.J. Pallen, B.L. Tang, and Z.C. Xiao (2003) Nogo-A at CNS paranodes is a ligand of Caspr: a possible role in regulating K+ channel localization. EMBO J. 22, 5666-5678.
Q.D. Hu, B.T. Ang, M. Karsak, W.P. Hu, X.Y. Cui, T. Duka, Y. Takeda, W. Chia, S. Natesan, Y.K. Ng, E.A. Ling, T. Maciag, D. Small, R. Trifonova, R. Kopan, H. Okano, M. Nakafuku, S. Chiba, H. Hirai, J.C. Aster, M. Schachner, C.J. Pallen, K. Watanabe, and Z.C. Xiao (2003) F3/Contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell 115, 163-175 (cover story).
Research Support
Monash Professional Fellowship
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