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Embryonic Stem Cell Differentiation LaboratoryGroup Leaders: Professors: Andrew Elefanty and Ed Stanley
Postal AddressEmbryonic Stem Cell Differentiation Laboratory
Image GalleryCurrent laboratory membersResearch FellowsDr Magdaline Costa Research AssistantsMs Lisa Azzola PhD studentsMs Julie Cao
Honours studentsMs Freya Bruveris Research OverviewResearch in the laboratory that jointly headed by Prof. Andrew Elefanty and Prof. Ed Stanley is focused on the biology and manipulation of human embryonic stem (ES) cells. Our major interest is in the regulation of ES cell differentiation to mesendodermal precursors (corresponding to the primitive streak in the mammalian embryo) and then to mesodermal and endodermal lineages, as exemplified by blood, heart and endothelium and pancreatic islet cells, respectively.
Recent PublicationsGoulburn AL, Alden D, Davis RP, Micallef SJ, Ng ES, Yu QC, Lim SM, Soh CL, Elliott DA, Hatzistavrou T, Bourke J, Watmuff B, Lang RJ, Haynes JM, Pouton CW, Giudice A, Trounson AO, Anderson SA, Stanley EG, Elefanty AG. (2011) A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives. Stem Cells. 29(3):462-73 Nostro MC, Sarangi F, Ogawa S, Holtzinger A, Corneo B, Li X, Micallef SJ, Park IH, Basford C, Wheeler MB, Daley GQ, Elefanty AG, Stanley EG, Keller G. (2011) Stage-specific signaling through TGFb family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development. 138(5):861-71 Elefanty AG and Stanley EG. (2010) Defined substrated for pluripotent stem cells: are we there yet? Nat Methods. 7(12):967-8 Elefanty AG, Blelloch R, Passegue E, Wernig M, Mummery CL. (2010) On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010. Cell Stem Cell. 7(4):443-50 Hirst CE, Lim SE, Pereira LA, Mayberry RA, Stanley EG, Elefanty AG. (2010) Expression from a betageo gene trap in the Slain1 gene locus is predominantly associated with the developing nervous system. Int J Dev Biol. 54(8-9):1383-8 Jackons SA, Schiesser J, Stanley EG, Elefanty AG. (2010) Differentiating embryonic stem cells pass through ‘temporal windows' that mark responsiveness to exogenous and paracrine mesendoderm inducing signals. PLoS One. 5(5):e10706 Heraud P, Ng ES, Caine S, Yu QC, Hirst C, Mayberry R, Bruce A, Wood BR, McNaughton D, Stanley EG, Elefanty AG. (2010) Fourier transform infrared microspectroscopy identifies early lineage commitment in differentiating human embryonic stem cells. Stem Cell Res. 4(2):140-7 Lim SM, Pereira L, Wong MS, Hirst CE, Van Vranken BE, Pick M, Trounson A, Elefanty AG and Stanley EG. Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation. Stem Cells, 27, 363-374, 2009. Holland AM, Elefanty AG and Stanley EG. Pancreatic differentiation from pluripotent stem cells: tweaking the system. Cell Research 19:395-6, 2009. Davis RP, Grandela C, Dottori M, Hatzistavrou T, Sourris K, Elefanty AG, Stanley EG and Costa M. Generation of human embryonic stem cell reporter knock-in lines by homologous recombination. Curr Protoc Stem Cell Biol, 2009. In press. Elefanty AG and Stanley EG. Reshaping pluripotent stem cells. Nature Biotechnology 27, 823-824, 2009. Research SupportNational Health and Medical Research Council of Australia |