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Publication Highlights

Selected Peer Reviewed Publications 2006-2007

Immunology - stem cells - tolerance and thymic function - Group Leader: Professor Richard Boyd

Rossi SW, Chidgey AP, Parnell SM, Jenkinson WE, Scott HS, Boyd RL, Jenkinson EJ, Anderson G.(2007) Redefining epithelial progenitor potential in the developing thymus. Eur J Immunol. 37(9): 2411-8.

Goldberg GL, Alpdogan O, Muriglan SJ, Hammett MV, Milton MK, Eng JM, Hubbard VM, Kochman A, Willis LM, Greenberg AS, Tjoe KH, Sutherland JS, Chidgey A, van den Brink MR, Boyd RL.(2007) Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation (2007) J Immunol. 178(11):7473-84.

Gray DH, Tull D, Ueno T, Seach N, Classon BJ, Chidgey A, McConville MJ, Boyd RL. (2007) A unique thymic fibroblast population revealed by the monoclonal antibody MTS-15. J Immunol. 178(8):4956-65.

Alpdogan O, Hubbard VM, Smith OM, Patel N, Lu SX, Goldberg GL, Gray DH, Feinman J, Kochman AA, Eng JM, Muriglan SJ, Suh D, Boyd RL, van den Brink MR. (2006) Keratinocyte Growth Factor (KGF) Is Required For Post-Natal Thymic Regeneration. Blood, 107(6):2453-60.

Kurobe, H., Liu, C., Ueno, T., Saito, F., Ohigashi, I., Seach, N., Arakaki, R., Hayashi, Y., Kitagawa, T., Lipp, M., Boyd, R.L., and Takahama,Y. (2006) CCR7-dependent cortex to medulla migration of positively selected thymocytes is dispensable for T-cell maturation and thymic export but is essential for establishing central tolerance. Immunity. 24(2):165-77.

Uldrich, A.P., Berzins, S.P., Malin, M.A., Bouillet, P., Strasser, A., Smyth, M.J., Boyd, R.L.* and Godfrey, D.I.* (2006). Antigen challenge inhibits thymic emigration. J. Immunol. 176: 4553-4561 (* equal contribution)

Nijhof JG. Braun KM. Giangreco A. van Pelt C. Kawamoto H. Boyd RL. Willemze R. Mullenders LH. Watt FM. de Gruijl FR. van Ewijk W. (2006) The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells. Development. 133(15):3027-37.

Daniel H.D. Gray, Natalie Seach, Tomoo Ueno, Morag Milton, Adrian Liston, Andrew M. Lew, Christopher C. Goodnow, Richard L. Boyd (2006) Developmental kinetics, turnover and stimulatory capacity of thymic epithelial cells. Blood. 108(12):3777-85.

Chidgey AP and Boyd RL (2006) Stemming the tide of thymic ageing. Nature Immunology. 7(10):1013-6.

Jeremy Millar, Jayne Sutherland, & Richard Boyd (2006) Alternative explanations for T-cell response to in-situ gene therapy for prostate cancer: In reply to Fugita et al (Int. J. Radiation Oncology Biol. Phys., Vol. 65, No. 1, pp. 84-90, 2006). International Journal of Radiation Oncology, Biology, Physics, 66 (5): 1599.

Neuroimmunology - Group Leader: Professor Claude Bernard

Huntington ND, Tomioka R, Clavarino C, Chow AM, Linares D, Mana P, Rossjohn J, Cachero, TG, Qian F, Kalled SL, Bernard CC, Reid HH. A BAFF antagonist suppresses experimental autoimmune encephalomyelitis by targeting cell-mediated and humoral immune responses. Int. Immunol. 2006; 18:1473-1485.

Azari MF, Profyris C, Karnezis T, Bernard CC, Small DH, Cheema SS, Ozturk E, Hatzinisiriou I, Petratos S Leukemia Inhibitory Factor Arrests Oligodendrocyte Death and Demyelination in Spinal Cord Injury. JNEN 2006; 65: 914-929

McQualter JL, Bernard CC. Multiple Sclerosis: A battle between degeneration and repair. J. Neurochem. 2006:100:295-306.

Embryonic Stem Cell Differentiation Laboratory - Group Leaders: Associate Professor Andrew Elefanty and Dr Ed Stanley

Pick M, Azzola L, Mossman A, Stanley EG, Elefanty AG.(2007) Differentiation of human embryonic stem cells in serum-free medium reveals distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis. Stem Cells 25(9):2206-14.

Costa M, Dottori M, Sourris K, Jamshidi P, Hatzistavrou T, Davis R, Azzola L, Jackson S, Lim SM, Pera M, Elefanty AG, Stanley EG.A method for genetic modification of human embryonic stem cells using electroporation. Nat Protoc. 2(4):792-6.

Holland AM, Micallef SJ, Li X, Elefanty AG, Stanley EG (2006) A mouse carrying the green fluorescent protein gene targeted to the Pdx1 locus facilitates the study of pancreas development and function. Genesis. 44(6):304-7.

Hirst CE, Ng ES, Azzola L, Voss AK, Thomas T, Stanley EG and Elefanty AG. Transcriptional profiling of mouse and human ES cells identifies SLAIN1, a novel stem cell gene. Dev Biol, 2006 May 1;293(1):90-103.

Fetal Development, Stem Cells and Differentiation Group - Group Leader:

Miller SL, Chai M, Loose J, Castillo-Meléndez M, Walker DW, *Jenkin G*, Wallace EM. (2007) The effects of maternal betamethasone administration on the intrauterine growth restricted fetus. Endocrinology. 148(3):1288-95

Wilson TJ, Lacham-Kaplan O, Gould J, Holloway A, Bertoncello I, Hertzog PJ, Trounson A (2007) Comparison of mice born after intracytoplasmic sperm injection with in vitro fertilization and natural mating. Mol Reprod Develop (September 22^nd 2006, Epub ahead of print).

Jones GM, Song B, Cram DS, Trounson AO (2007) Optimization of a microarray based approach for deriving representative gene expression profiles from human oocytes. Mol Reprod Develop 74: 8-17.

Daley GQ,..Trounson AO… et al (2007) The ISSCR Guidelines for Human Embryonic Stem Cell Research. Science 315: 603-604.

Trounson A (2007) A fluid means of stem cell generation. Nature Biotech 25: 62-63.

Taylor R, Cowin PA, Cunha GR, Pera M, Trounson AO, Pedersen J, Risbridger GP (2006) Formation of human prostate tissue from embryonic stem cells. Nature Methods 3: 179-181.

Lacham-Kaplan O, Chy H, Trounson A (2006) Testicular cell conditioned medium supports differentiation of embryonic stem cells into ovarian structures containing oocytes. Stem Cells 24: 266-273.

Thouas GA, Trounson AO, Jones GM (2006) Developmental effects of sublethal mitochondrial injury in mouse oocytes. Biol. Reprod. 74: 969-977.

Davis T, Song B, Cram DS (2006) Successful preimplantation diagnosis of familial adenatomatous polyposis. Reprod Biomed Online 13: 707-711.

Cram DS, Osborne E, McLachlan RI (2006) Y chromosome microdeletions - implications for assisted conception. Med J Aust 185: 433-434.

Bott EM, Young IR, Jenkin G, McLaren WJ. (2006) Detection of morphological changes of the ovine cervix in response to sex steroids using a fluorescence confocal endomicroscope. American Journal of Obstetrics and Gynaecology 194:105-112.

Supramaniam VG, Jenkin G, Loose J, Wallace EM, Miller SL. (2006) Chronic fetal hypoxia increases activin A concentrations in the late pregnant sheep. British Journal of Obstetrics and Gynaecology 113:102-109.

Yang H, Cox S-L, Jenkin G, Findlay J,Trounson A, Shaw J. (2006) Graft site and gonadotrophin stimulation influences on the number and quality of oocytes from murine ovarian tissue grafts. Reproduction 131:851-859.

Rodricks CL, Miller SL, Jenkin G, Gibbs M. (2006) The role of corticosterone in prehatch-induced memory deficits in chicks. Brain Research 1123:34-41.

Adult stem cells in renal regeneration and repair - Group Leader: Dr Sharon Ricardo

Verghese E, Weidenfeld R, Bertram JF, Ricardo SD, Deane JA. (2007) Renal Cilia Display Length Alterations Following Tubular Injury and are Present Early in Epithelial Repair. Nephrol Dial Transplant. 2007 Oct 25 [Epub ahead of print]

Li J, Deane JA, Campanale NV, Bertram JF, Ricardo SD. (2007) The contribution of bone marrow-derived cells to the development of renal interstitial fibrosis. Stem Cells. 25(3):697-706.

Gillard A, Scarff k, Loveland K, Ricardo SD and Bird PI. Modulation and redistribution of Proteinase Inhibitor 8 (Serpinb8) expression during kidney regeneration. Am J Nephrol 26:34-42, 2006.

Challen GA, Bertoncello I, Deane JA, Ricardo SD, Little MH. The kidneys side population reveals multi-lineage potential and renal functional capacity but also cellular heterogeneity. J Am Soc Nephrol 17(7):1896-912, 2006.

Li J, Deane JA, Campanale NV, Bertram JF, Ricardo SD. Blockade of p38 MAPK and TGF-b1/Smad Signaling Pathways Rescues Bone Marrow-derived Peritubular Capillary Endothelial Cells in Adriamycin-induced Nephrosis. J Am Soc Nephrol 17(10):2799-2811, 2006.

Li J, Campanale NV, Bertram JF, Ricardo SD. p38 MAPK and TGF-b/Smad Signaling Pathways co-ordinate Renal Fibrosis in Adriamycin-induced Nephrosis. Am J Pathol 169(5):1527-1540, 2006.

Li J, Deane JA, Campanale NV, Bertram JF, and Ricardo SD. Modulation of the contribution of bone marrow-derived cells to renal repair and the development of interstitial fibrosis. Stem Cells (published Stem Cell Express Dec 14th), 2006.

Previous Publication Highlights

Goldberg et al. Transplantation 2005 (pdf, 911kb)
Goldberg GL, Sutherland JS, Hammet MV, Milton MK, Heng TSP, Chidgey AP, Boyd RL (2005) Sex Steroid Ablation Enhances Lymphoid Recovery Following Autologous Hematopoietic Stem Cell Transplantation. Transplantation. 80(11):1604-13

Heng et al. Journal of Immunology 2005 (pdf, 747kb) Heng TS, Goldberg GL, Gray DH, Sutherland JS, Chidgey AP, Boyd RL.(2005) Effects of castration on thymocyte development in two different models of thymic involution. J Immunol. 175(5):2982-93.

Sutherland et al. Journal of Immunology 2005 (pdf, 1033kb)
Sutherland JS, Goldberg GL, Hammett MV, Uldrich AP, Berzins SP, Heng TS, Blazar BR, Millar JL, Malin MA, Chidgey AP, Boyd RL. (2005) Activation of thymic regeneration in mice and humans following androgen blockade. J Immunol. 175(4):2741-53.

Micaleff et al Diabetes 2005 (pdf, 352kb)
Micallef SJ, Janes ME, Knezevic K, Davis RP, Elefanty AG, Stanley EG. (2005) Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells. Diabetes. 54(2):301-5.

Ng et al. Blood 2005a (pdf, 248kb)
Ng ES, Davis RP, Azzola L, Stanley EG, Elefanty AG.(2005) Forced aggregation of defined numbers of human embryonic stem cells into embryoid bodies fosters robust, reproducible hematopoietic differentiation. Blood. 106(5):1601-3.

Ng et al. Development 2005 (pdf, 899kb)Ng ES, Azzola L, Sourris K, Robb L, Stanley EG, Elefanty AG.(2005) The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells. Development. 132(5):873-84.

Mossman et al. Stem Cells and Development 2005 (pdf, 170kb)
Mossman AK, Sourris K, Ng E, Stanley EG, Elefanty AG.(2005) Mixl1 and oct4 proteins are transiently co-expressed in differentiating mouse and human embryonic stem cells.Stem Cells Dev. 14(6):656-63.

Costa and Dottori et al. Nature Methods 2005 (pdf, 391kb)
Costa M, Dottori M, Ng E, Hawes SM, Sourris K, Jamshidi P, Pera MF, Elefanty AG, Stanley EG.(2005) The hESC line Envy expresses high levels of GFP in all differentiated progeny. Nat Methods. 2(4):259-60.

Serafica et al. Human Reproduction 2005 (pdf, 526kb)

Cochrane et al. J Am Soc Nephrol 2005 (pdf, 829kb)
Cochrane AL, Kett MM, Samuel CS, Campanale NV, Anderson WP, Hume DA, Little MH, Bertram JF, Ricardo SD. (2005) Renal structural and functional repair in a mouse model of reversal of ureteral obstruction J Am Soc Nephrol (12): 3623-30.

Ricardo and Deane Nephrology 2005 (pdf, 108kb)

Ng et al. Hematopoiesis 2005 (pdf, 249kb)

Lacham-Kaplan et al. Stem Cells 2005 (pdf, 465kb)

Thouas et al. Biology of Reproduction 2005 (pdf, 270kb)

Li et al. J American Society Nephrology (pdf, 2mb)