Molecular basis for pathogenesis in leptospirosis
|Shadowed electron micrograph of Leptospira||Epidemiology of leptospirosis|
Leptospirosis is a zoonosis of worldwide significance caused by infection with serovars of the genus Leptospira. Work involves the detailed analysis of leptospiral antigens, especially those with potential roles in immunity and vaccine development. A second approach involves mutagenesis of leptospiral genes to identify and characterise leptospiral proteins with roles in pathogenesis and immunity to infection.
The Monash University Leptospira Laboratory also performs a diagnostic function for human leptospirosis.
The International Leptospirosis Society home page provides further information and useful links on leptospirosis.
Khon Kaen University, Khon Kaen, Thailand
Institut Pasteur, Paris, France
Institut Pasteur, Noumea, New Caledonia
Yale University, New Haven, USA
Oswaldo Cruz Foundation, Salvador, Brazil
University of the Ryukyus, Okinawa, Japan
University of California and Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, USA
Pathogenesis and immunity in fowl cholera
|Thin section electron micrograph of Pasteurella showing extracellular capsule|
Pasteurella multocida is the causative agent of fowl cholera, bovine haemorrhagic septicaemia, and porcine atrophic rhinitis. Genetic loci involved in virulence are being identified and analysed by cloning, mutagenesis, sequencing etc in order to determine their roles in pathogenesis at the molecular level. There is a particular focus on in vivo expressed genes; we have established genetic systems to detect these genes. Monoclonal and polyclonal antibodies are used to characterise antigens and to assess their roles in immunity. Genes encoding membrane proteins and the synthesis of LPS and of surface polysaccharide capsule are being characterised. In addition, genetically manipulated mutants are being assessed for their potential as live, attenuated vaccines.
Research staff: Dr Marina Harper, Amy Wright
University of Queensland, Brisbane, Australia
CSIRO Livestock Industries, Geelong, Australia
Institute for Biological Sciences, Ottawa, Canada
Pathogenesis and immunity in meliodosis
Antibiotic resistance in Acinetobacter baumannii
For information on these projects, please refer to the web pages of my colleague Dr John Boyce