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Monash Centre for Inflammatory Diseases

Professor Ban-Hock Toh

Professor Ban-Hock Toh

Professor Ban-Hock Toh leads the Centre for Inflammatory Diseases Auto-Immunity team. He held appointments at Universities in Singapore (1967-1968) and Malaysia (1969-1970), before joining Monash University in 1972.

Professor Toh was the Head of the Department of Immunology (1995-2005) and Senior Staff Specialist in Immunology at theAlfred Hospital (1997-2005). He was Chief Examiner for the Royal College of Pathologists Australia in Immunology (1995-2000), Regional Editor (Australasia) for Autoimmunity (1993-2001), Commonwealth Medical Fellow, MRC Immunology Unit, London (1979), Fogarty Visiting Scientist, National Institutes of Health, USA (1983 and 1989), Visiting Professor, University of Singapore (1992) and University of Innsbruck, Austria (2002).

In 2006, he accepted a fractional professorial appointment in the Centre for Inflammatory Diseases. He is an Honorary Professor, Monash Immunology and Stem Cell Laboratory, Professorial Fellow, Baker Heart Research Institute and Immunologist, Gribbles Pathology.

His track record includes over 200 publications, including 7 letters to Nature and 19 book chapters. He is internationally recognised for his work on autoimmune gastritis and pernicious anaemia.

Publications 2002-2007

  1. Tu Y, Wu W, Wu T, Cao Z, Wilkins R, Toh BH, Cooper M, Chai Z. Antiproliferative autoantigen CDA1 transcriptionally upregulates p21Wafl/Cip1 by activating p53 and MEK/ERK1/2 MAPK pathways. J Biol Chem. 2007 Feb 22.
  2. Chan J, Clements W, Field J, Nasa Z, Lock P, Yap F, Toh BH, Alderuccio F. Transplantation of bone marrow genetically engineered to express proinsulin II protects against autoimmune insulitis in NOD mice. J Gene Med. 2006 Nov;8(11):1281-90.
  3. Ditiatkovski M, Toh BH, Bobik A.GM-CSF deficiency reduces macrophage PPAR-gamma expression and aggravates atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2337-44.
  4. Biondo M, Field J, Toh BH, Alderuccio F. Prednisolone promotes remission and gastric mucosal regeneration in experimental autoimmune gastritis. J Pathol. 2006 Jul;209(3):384-91.
  5. Siatskas C, Chan J, Field J, Murphy K, Nasa Z, Toh BH, Alderuccio F. Gene therapy strategies towards immune tolerance to treat the autoimmune diseases. Curr Gene Ther. 2006 Feb;6(1):45-58.
  6. Li H, Xu D, Toh BH, Liu JP. TGF-beta and cancer: is Smad3 a repressor of hTERT gene? Cell Res. 2006 Feb;16(2):169-73.
  7. Li H, Pinto AR, Duan W, Li J, Toh BH, Liu JP. Telomerase down-regulation does not mediate PC12 pheochromocytoma cell differentiation induced by NGF, but requires MAP kinase signalling. J Neurochem. 2005 Nov;95(3):891-901.
  8. Hirota T, Lipp JJ, Toh BH, Peters JM.Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature. 2005 Dec 22;438(7071):1176-80.
  9. Lin JL, Dubljevic V, Fritzler MJ, Toh BH. Major immunoreactive domains of human ribosomal P proteins lie N-terminal to a homologous C-22 sequence: application to a novel ELISA for systemic lupus erythematosus. Clin Exp Immunol. 2005 Jul;141(1):155-64.
  10. Alderuccio F, Murphy K, Biondo M, Field J, Toh BH. Reversing the autoimmune condition: experience with experimental autoimmune gastritis. Int Rev Immunol. 2005 Jan-Apr;24(1-2):135-55.
  11. Marshall AC, Alderuccio F, Murphy K, Toh BH. Mechanisms of gastric mucosal cell loss in autoimmune gastritis. Int Rev Immunol. 2005 Jan-Apr;24(1-2):123-34.
  12. Field J, Biondo MA, Murphy K, Alderuccio F, Toh BH. Experimental autoimmune gastritis: mouse models of human organ-specific autoimmune disease. Int Rev Immunol. 2005 Jan-Apr;24(1-2):93-110.
  13. Toh BH, Alderuccio F.Pernicious anaemia. Autoimmunity. 2004 Jun;37(4):357-61.
  14. Alderuccio F, Toh BH. Induction of tolerance to self-antigens using genetically modified bone marrow cells. Expert Opin Biol Ther. 2004 Jul;4(7):1007-14.
  15. Kakinuma T, Ichikawa H, Tsukada Y, Nakamura T, Toh BH. Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery. Exp Cell Res. 2004 Aug 15;298(2):388-98.
  16. Marshall AC, Toh BH, Alderuccio F. Tumor necrosis factor alpha is not implicated in the genesis of experimental autoimmune gastritis. J Autoimmun. 2004 Feb;22(1):1-11.
  17. Field J, Marshall AC, J Hertzog P, Wells TN, Alderuccio F, Toh BH. Chemokine receptor CCR5 is not required for development of experimental autoimmune gastritis. Clin Immunol. 2003 Nov;109(2):238-47.
  18. Alderuccio F, Murphy K, Toh BH. Stem cells engineered to express self-antigen to treat autoimmunity. Trends Immunol. 2003 Apr;24(4):176-80.
  19. Murphy K, Biondo M, Toh BH, Alderuccio F. Tolerance established in autoimmune disease by mating or bone marrow transplantation that target autoantigen to thymus. Int Immunol. 2003 Feb;15(2):269-77.
  20. Mackay IR, Toh BH. Autoimmune hepatitis: the way we were, the way we are today and the way we hope to be. Autoimmunity. 2002 Aug;35(5):293-305.
  21. Marshall AC, Alderuccio F, Toh BH.Fas/CD95 is required for gastric mucosal damage in autoimmune gastritis. Gastroenterology. 2002 Sep;123(3):780-9.
  22. Greenwood DL, Gitlits VM, Alderuccio F, Sentry JW, Toh BH. Autoantibodies in neuropsychiatric lupus. Autoimmunity. 2002 Mar;35(2):79-86.
  23. Dunster K, Toh BH, Sentry JW. Early endosomes, late endosomes, and lysosomes display distinct partitioning strategies of inheritance with similarities to Golgi-derived membranes. Eur J Cell Biol. 2002 Mar;81(3):117-24.
  24. Alderuccio F, Biondo M, Toh BH. Organ-specific autoimmunity in granulocyte macrophage-colony stimulating factor (GM-CSF) deficient mice. Autoimmunity. 2002 Feb;35(1):67-73.

Book Chapters

  1. Toh, BH, Sentry J and F. Alderuccio, “Autoimmune gastritis and pernicious anemia. CD4 T cell mediated tolerance and autoimmunity to the gastric H/K ATPase”. Theofilopoulos AN and Bona CA. “Molecular Pathology of Autoimmunity” Gordon and Breach, 2002, 841-862.
  2. Toh, BH, Biondo M, Marshall A, Greenwood D, Sentry J and Alderuccio F. The gastric H/K ATPase in the pathogenesis of autoimmune gastritis. In “Mechanisms and consequences of proton transport”. Urushidani T, forte JG and Sachs G (Eds). Kluwer Academic Publishers, 2002. P.107-114.
  3. Toh BH, Whittingham S and Alderuccio F. “Autoimmune gastritis and pernicious anemia.” Rose NR and Mackay (Eds). “The Autoimmune Diseases”, Rose N and Mackay IR, 4th Edition, Elsevier, p.527-546, 2006.
  4. Toh BH and F. Alderuccio. “Parietal cell and intrinsic factor autoantibodies” Yehuda Shoenfeld Y, Meroni PL and M. Eric Gershwin. “Autoantibodies”, 2006, in press.
  5. IR Mackay, R Martinez-Neira, S Whittingham and BH Toh “Autoantigenicity of Actin” in “Actin”. Cristobal Gl dos Remedios and Deepak Chhabra (ed). Springer-Verlag, 2007, in press.

Major Collaborators

  • Professor Alex Bobik
  • Professor Mark Cooper
  • Dr. Zhonglin Chai