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Monash Centre for Inflammatory Diseases

Associate Professor Peter Tipping

A/Prof Peter Tipping

A/Prof Peter Tipping is an NH&MRC Principal Research Fellow, who has been continuously funded by the NHMRC for the past 20 years and has supervised 18 honours students and 13 PhD students over this period.  He is clinician/scientist with expertise in animal models of human inflammatory diseases and has received international recognition for work using mouse models to dissect the pathogenic mechanisms in crescentic glomerulonephritis.

He received the Silver Jubilee Research Prize from the Faculty of Medicine in 2000 and the TJ Neale Prize for Outstanding Contribution to Nephrological Science awarded by the Australian and New-Zealand Society of Nephrology in 1995.  He is member of the editorial boards of the American Journal of Pathology, Clinical and Experimental Nephrology, Nephron – Experimental Nephrology, and Faculty of 1000 – Nephrology Faculty and is a section editor for Nephrology.

The current focus of his research group is the interactions between coagulation and inflammation inflammatory diseases including glomerulonephritis, atherosclerosis arthritis and endotoxaemia, with a major interest is on the role of tissue factor and protease activated receptors.

Publications 2002 - 2008

Reviews and Editorials.

  1. Crescentic glomerulonephritis…is in your genes?  Nephrol Dial Transplant. 2008 Jul 25.
  2. Tipping PG.  Are podocytes passive or provocative in proteinuric glomerular pathology? J Am Soc Nephrol, 19:651-3, 2008.
  3. Tipping PG and Holdsworth SR.  Cytokines in glomerulonephritis.  Semin Nephrol. 27:275-85, 2007
  4. Tipping PG.  Toll-like receptors: the interface between innate and adaptive immunity.  J Am Soc Nephrol. 17, 1769-71, 2006.
  5. Tipping PG and Holdsworth SR.  T cells in crescentic glomerulonephritis.  J Am Soc Nephrol, 17:1253-63, 2006.
  6. Tipping PG and Kitching AR.  Glomerulonephritis, Th1 and Th2: what’s new?  Clin Exp Immunol 142:207-15, 2005
  7. Tipping PG and Timoshanko JR.  Contributions of intrinsic renal cells to crescentic glomerulonephritis.  Nephron Exp Nephrol  101:e173-8, 2005
  8. Timoshanko JR and Tipping PG. Resident kidney cells and their involvement in glomerulonephritis.  Current Drug Targets-Inflamm Allergy 4:353-362, 2005.
  9. Tipping PG and Holdsworth SR.  T cells in glomerulonephritis.  Springer Seminars in Immunopathol 24:377-93. 2003

Original Articles.

  1.  Kitching AR, Li M and Tipping PG The cytoplasmic domain of tissue factor in macrophages augments cutaneous delayed type hypersensitivity.  J Leukoc Biol. 83:902 -911, 2008.
  2. Moussa L, Apostolopoulos JA, Davenport P, Tchongue J and Tipping PG.  Protease activated receptor -2 augments experimental crescentic glomerulonephritis.  Am J Pathol 171:800-8, 2007.
  3. Tipping P, Boyce N, Bellomo R.  A pilot study of high-adsorption hemofiltration in human septic shock.  Int J Artif Organs, 30:108-17, 2007.
  4. Timoshanko JR, Kitching AR, Semple T, Tipping PG and Holdsworth SR.  A pathogenic role for mast cells in experimental crescentic glomerulonephritis.  J Am Soc Nephrol, 17:150-9, 2006.
  5. Santos L, Xue J, Tipping PG and Morand EF.  Reduction of arthritis severity in protease activated receptor deficient mice.  Arthritis Rheum. 52: 1325-1332, 2005.
  6. Kitching AR, Turner AL, Wilson GRA, Semple TJ, Odobasic D, Timoshanko JR, O’Sullivan KM, Tipping PG, Takeda K, Akira S and Holdsworth SR.  IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, while IL-18 promotes local inflammation and leukocyte recruitment. J Am Soc Nephrol 16:2023-33, 2005.
  7. Odobasic D, Kitching AR, Semple TJ, Timoshanko JT, Tipping PG, and Holdsworth SR. Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis J Am Soc Nephrol 16:2012-22, 2005.
  8. Kitching AR, Semple T, Holdsworth SR and Tipping PG.  GM-CSF production by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis. J Am Soc Nephrol 16: 2646-2656, 2005.
  9. Odobasic D, Kitching AR, Tipping PG and Holdsworth SR.  CD80 and CD86 co-stimulatory molecules regulate crescentic glomerulonephritis by different mechanisms, Kidney Int 68:584-594, 2005.
  10. Tipping PG, Kipari T, Cailhier JF, Clay S, Lang R, Bonventre JV and Hughes J. Conditional ablation of macrophages halts progression of crescentic glomerulonephritis.  Am J Pathol,167:1207-1219, 2005.
  11. Yang YH, Hall P, Milenkovski G, Sharma L, Hutchinson P, Melis E, Carmeliet P, Tipping P and Morand E. Reduction in arthritis severity and modulation of immune function in tissue factor cytoplasmic domain mutant mice. Am J Pathol. 164: 109-17. 2004.
  12. Timoshanko JR, Kitching, AR, Iwakura Y, Holdsworth SR and Tipping PG. Contributions of IL-1β and IL-1a to crescentic glomerulonephritis in mice, J Am Soc Nephrol 15:910-8, 2004.
  13. Timoshanko JR, Kitching, AR, Iwakura Y, Holdsworth SR and Tipping PG. Leukocyte derived IL-1ß interacts with renal IL-1 receptor I to promote renal TNF and glomerular injury in murine crescentic glomerulonephritis. Am J Pathol. 164:1967-72, 2004.
  14. Cunningham MA, Kitching AR, Tipping PG and Holdsworth SR.  Fibrin independent pro-inflammatory effects of tissue factor in experimental crescentic glomerulonephritis.  Kidney Int 66:647-54, 2004.
  15. Tipping PG and Holdsworth SR.  An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity. J Immunol. 173:136-44, 2004.
  16. Sharma L, Melis E, Hickey M, Clyne CD, Davenport P, Erlich JH, Morand EF, Carmeliet P, and Tipping PG. The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxaemia Am J Pathol 165: 331-340, 2004.
  17. , Turner AL, Wilson GRA, Edgtton KL, Tipping PG, Holdsworth SR.  Endogenous IL-13 limits humoral responses and injury in experimental glomerulonephritis but does not regulate Th1 cell mediated crescentic glomerulonephritis. J Am Soc Nephrol 15: 2373-82, 2004.
  18. Cole L, Bellomo R, Davenport P, Tipping P, Ronco C. Cytokine removal during continuous renal replacement therapy: An ex-vivo comparison of convection and diffusion. Int J Artif Organs 27: 388-397, 2004.
  19. Timoshanko JR, Sedgwick JD, Holdsworth SR Tipping PG.  Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis.  J Am Soc Nephrol 14: 1785-93, 2003.
  20. Ruth A-J, Kitching AJ, Semple TJ, Tipping PG and Holdsworth SR. Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis. J Am Soc Nephrol 14: 2813-22, 2003
  21. Davenport P and Tipping PG. The role of interleukin-12 and interleukin-4 in progression of atherosclerosis in apoE deficient mice, Am J Pathol, 163: 1117-25, 2003.
  22. Kitching AR, Kong YZ, Huang XR, Davenport P, Edgtton KL, Carmeleit P, Holdsworth SR and Tipping PG.  Plasminogen Activator Inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis. J Am Soc Nephrol 14: 1487-97, 2003
  23. Timoshanko JR, Holdsworth SR Kitching AR and Tipping PG. IFN-g production by intrinsic renal cells and bone marrow derived cells is required for full expression of crescentic glomerulonephritis in mice J Immunol 168:4135-41, 2002
  24. Kitching AR, Huang XR, Ruth AJ, Tipping PG, Holdsworth SR. Effects of CTLA4-Fc on glomerular injury in humorally-mediated glomerulonephritis in BALB/c mice. Clin Exp Immunol. 12:429-35, 2002.
  25. Yuan HT, Tipping PG, Li XZ, Long D and Woolf A.  Angiopoietin correlates with glomerular capillary loss in experimental anti-glomerular basement membrane glomerulonephritis. Kidney Int 61: 2078-2089, 2002.
  26. Luttun A, Lupu F, Strokebaum E, Hoylaerts MF, Moons L, Crawley J, Bono F, Poole AR, Tipping P, Herbert J-M, Collen D and Carmeleit P  Lack of plasminogen activator–1 (PAI-1) promotes growth and abnormal matrix remodelling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice.  Atherioscler Thromb Vasc Biol, 22:499-505, 2002.
  27. Kitching AR, Huang XR, Turner A, Tipping PG, Dunn AR, Holdsworth SR. The requirement for GM-CSF and G-CSF in leukocyte mediated immune glomerular injury. J Am Soc Nephrol 13:350-8, 2002.
  28. Kitching AR, Katerelos M, Mudge SJ, Tipping PG, Power DA and Holdsworth SR.  Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis Clin Exp Immunol 128:36-43, 2002.
  29. Cole L, Bellomo R, Davenport P, Tipping P, Uchino S, Tetta C, Ronco C.  The effect of coupled haemofiltration and adsorption on inflammatory cytokines in an ex vivo model. Nephrol Dial Transplant. 17:1950-6, 2002.
  30. Davenport P, Tipping P and Ronco C. A phase II randomized controlled trial of continuous hemofiltration in sepsis. Crit Care Med; 30: 100-106, 2002.
  31. Uchino S, Bellomo R, Goldsmith D, Davenport P, Cole L, Baldwin I, Panagiotopoulos S and Tipping P. Super high flux hemofiltration: A new technique for cytokine removal.  Intensive Care Med 28:651-655, 2002.
  32. Uchino S, Bellomo R, Morimatsu H, Goldsmith D, Davenport P, Cole L, Baldwin I, Panagiotopoulos S, Tipping P, Morgera S, Neumayer HH, Goehl H. Cytokine dialysis: an ex vivo study. ASAIO J. 48:650-3. 2002
  33. Uchino S, Bellomo R, Goldsmith D, Davenport P, Cole L, Baldwin I, Panagiotopoulos S and Tipping P, Ronco C and Everard P. Cytokine removal with a large pore cellulose triacetate filter: An ex-vivo study.  Int J Artif Organs. 25: 27-32 2002.