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Monash Centre for Inflammatory Diseases

Associate Professor Richard Kitching - Deputy Director of Centre

Associate Professor Richard Kitching

Associate Professor Richard Kitching is a Chief Investigator with the Centre for Inflammatory Disease’s Glomerulonephritis Group. He is a clinician-scientist, his Clinical Specialty being nephrology.

Associate Professor Kitching's research helped established that the T-helper cell subsets (Th1/Th2) are applicable to glomerulonephritis. He defined the role of major elements of the fibrinolytic system in renal disease. In recent years he has set up, with collaborators, several different models of immune renal disease to explore hypotheses related to the pathogenesis of immune and autoimmune renal injury. He is a Chief Investigator in an NHMRC Program Grant and holds an NHMRC Project Grant (2009-2011) and a Genzyme Renal Innovations Program Grant (2008-2010).

Associate Professor Kitching co-authored the definitive review article on Th1/Th2 responses in renal disease. He is a member of the Editorial Board of the Journal of the American Society of Nephrology and is a Section Editor on the board of Nephrology. He was awarded the Australian and New Zealand Society of Nephrology TJ Neale Award for Outstanding Contribution to Nephrological Science in 2007.

He is the chair of the Scientific Programme and Education Committee of the Australia and New Zealand Society of Nephrology. He has served on NHMRC Project Grant Review Channels as a panel member, Deputy Chair and Chair.

He has teaching and leadership roles in the Monash University Faculty of Medicine Nursing and Health Sciences in the MBBS degree and the Bachelor of Biomedical Sciences degree.

Publications 2002-2008

  1. Kitching AR, Kuligowski MP, Hickey MJ. In Vivo Imaging of Leukocyte Recruitment to Glomeruli in Mice Using Intravital Microscopy. In Hewitson TD & Becker GJ (Eds.). Methods in Mol Biol, Kidney Research: Experimental Protocols, in press 2008
  2. Phoon RKS, Kitching AR, Holdsworth SR. Goodpasture’s Syndrome. In Bellomo R (Ed.): Textbook of Intensive Care Nephrology, in press 2008.
  3. Ooi JD, Holdsworth SR, Kitching AR. Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells. J Autoimmun. 2008 May 22.
  4. Phoon RK, Kitching AR, Odobasic D, Jones LK, Semple TJ, Holdsworth SR. T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis. J Am Soc Nephrol. 2008 Mar;19(3):477-85.
  5. Holdsworth SR, Kitching AR. Pathogenesis of Renal Disease – Cytokines and Other Soluble Factors. In Pusey CD (Ed.), Handbook of Systemic Autoimmune Diseases, Vol 7. The Kidney in Systemic Autoimmune Diseases, pp 63-79.
  6. Leech M, Xue JR, Dacumos A, Hall P, Santos L, Yang Y, Li M, Kitching AR, Morand EF. The tumour suppressor gene p53 modulates the severity of antigen-induced arthritis and the systemic immune response. Clin Exp Immunol. 2008 May;152(2):345-53.
  7. Kitching AR, Holdsworth SR, Hickey MJ. Targeting leukocytes in immune glomerular diseases. Curr Med Chem. 2008;15(5):448-58.
  8. Edgtton KL, Kausman JY, Li M, O'Sullivan K, Lo C, Hutchinson P, Yagita H, Holdsworth SR, Kitching AR. Intrarenal antigens activate CD4+ cells via co-stimulatory signals from dendritic cells. J Am Soc Nephrol. 2008 Mar;19(3):515-26.
  9. Apostolopoulos J, Hickey MJ, Sharma L, Sharma L, Davenport P, Moussa L, James WG, Gregory JL, Kitching AR, Li M, Tipping PG. The cytoplasmic domain of tissue factor in macrophages augments cutaneous delayed-type hypersensitivity. J Leukoc Biol. 2008 Apr;83(4):902-11.
  10. Odobasic D, Kitching AR, Semple TJ, Holdsworth SR. Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. J Am Soc Nephrol. 2007 Mar;18(3):760-70.
  11. Lassila M, Fukami K, Jandeleit-Dahm K, Semple T, Carmeliet P, Cooper ME, Kitching AR. Plasminogen activator inhibitor-1 production is pathogenetic in experimental murine diabetic renal disease. Diabetologia. 2007 Jun;50(6):1315-26.
  12. Kausman JY, Kitching AR. A new approach to idiopathic nephrotic syndrome. J Am Soc Nephrol. 2007 Oct;18(10):2621-2.
  13. Santos LL, Milenkovski GP, Hall PH, Leech M, Sharma L, Takeda K, Akira S, Kitching AR, Morand EF IL-18 is redundant in T-cell responses and in joint inflammation in antigen-induced arthritis. Immunol Cell Biol. 2006 Apr;84(2):166-73.
  14. Ruth AJ, Kitching AR, Kwan RY, Odobasic D, Ooi JD, Timoshanko JR, Hickey MJ, Holdsworth SR. Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis. J Am Soc Nephrol. 2006 Jul;17(7):1940-9.
  15. Odobasic D, Kitching AR, Semple TJ, Holdsworth SR. Inducible co-stimulatory molecule ligand is protective during the induction and effector phases of crescentic glomerulonephritis. J Am Soc Nephrol. 2006 Apr;17(4):1044-53.
  16. Li M, O'Sullivan KM, Jones LK, Kumanogoh A, Kikutani H, Holdsworth SR, Kitching AR. CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis. J Immunol. 2006 Sep 1;177(5):3406-12.
  17. Kuligowski MP, Kitching AR, Hickey MJ. Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling. J Immunol. 2006 Jun 1;176(11):6991-9.
  18. Hoi AY, Hickey MJ, Hall P, Yamana J, O'Sullivan KM, Santos LL, James WG, Kitching AR, Morand EF. Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice. J Immunol. 2006 Oct 15;177(8):5687-96.
  19. Apostolopoulos J, Ooi JD, Odobasic D, Holdsworth SR, Kitching AR. The isolation and purification of biologically active recombinant and native autoantigens for the study of autoimmune disease. J Immunol Methods. 2006 Jan 20;308(1-2):167-78.
  20. Tipping PG, Kitching AR. Glomerulonephritis, Th1 and Th2: what's new? Clin Exp Immunol. 2005 Nov;142(2):207-15.
  21. Timoshanko JR, Kitching AR, Semple TJ, Holdsworth SR, Tipping PG. Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis. J Am Soc Nephrol. 2005 Sep;16(9):2646-56.
  22. Odobasic D, Kitching AR, Tipping PG, Holdsworth SR. CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms. Kidney Int. 2005 Aug;68(2):584-94.
  23. Odobasic D, Kitching AR, Semple TJ, Timoshanko JR, Tipping PG, Holdsworth SR. Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis. J Am Soc Nephrol. 2005 Jul;16(7):2012-22.
  24. Kitching AR, Turner AL, Wilson GR, Semple T, Odobasic D, Timoshanko JR, O'Sullivan KM, Tipping PG, Takeda K, Akira S, Holdsworth SR.. IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment. J Am Soc Nephrol. 2005 Jul;16(7):2023-33.
  25. Kitching AR. More targeted treatments for lupus nephritis: is the future (nearly) here? J Am Soc Nephrol. 2005 Nov;16(11):3146-8.
  26. Dean EG, Wilson GR, Li M, Edgtton KL, O'Sullivan KM, Hudson BG, Holdsworth SR, Kitching AR. Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury. Kidney Int. 2005 Feb;67(2):566-75.
  27. Timoshanko JR, Kitching AR, Iwakura Y, Holdsworth SR, Tipping PG. Contributions of IL-1beta and IL-1alpha to crescentic glomerulonephritis in mice. J Am Soc Nephrol. 2004 Apr;15(4):910-8.
  28. Timoshanko JR, Kitching AR, Iwakura Y, Holdsworth SR, Tipping PG. Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis. Am J Pathol. 2004 Jun;164(6):1967-77.
  29. Ruth AJ, Kitching AR, Li M, Semple TJ, Timoshanko JR, Tipping PG, Holdsworth SR. An IL-12-independent role for CD40-CD154 in mediating effector responses: studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity. J Immunol. 2004 Jul 1;173(1):136-44.
  30. Kitching AR, Turner AL, Wilson GR, Edgtton KL, Tipping PG, Holdsworth SR. Endogenous IL-13 limits humoral responses and injury in experimental glomerulonephritis but does not regulate Th1 cell-mediated crescentic glomerulonephritis. J Am Soc Nephrol. 2004 Sep;15(9):2373-82.
  31. Kitching AR, Turner AL, Semple T, Li M, Edgtton KL, Wilson GR, Timoshanko JR, Hudson BG, Holdsworth SR.. Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma. J Am Soc Nephrol. 2004 Jul;15(7):1764-74.
  32. Kitching AR, Hutchinson P, Atkins RC, Holdsworth SR. The role of flow cytometric ANCA detection in screening for acute pauci-immune crescentic glomerulonephritis. Nephrol Dial Transplant. 2004 Feb;19(2):365-70.
  33. Edgtton KL, Gow RM, Kelly DJ, Carmeliet P, Kitching AR. Plasmin is not protective in experimental renal interstitial fibrosis. Kidney Int. 2004 Jul;66(1):68-76.
  34. Cunningham MA, Kitching AR, Tipping PG, Holdsworth SR. Fibrin independent proinflammatory effects of tissue factor in experimental crescentic glomerulonephritis. Kidney Int. 2004 Aug;66(2):647-54.
  35. Ruth AJ, Kitching AR, Semple TJ, Tipping PG, Holdsworth SR. Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis. J Am Soc Nephrol. 2003 Nov;14(11):2813-22.
  36. Kitching AR, Turner AL, O'Sullivan KM, Dewerchin M, Lijnen HR. Endogenous alpha2-antiplasmin does not enhance glomerular fibrin deposition or injury in glomerulonephritis. J Thromb Haemost. 2003 Sep;1(9):1992-9.
  37. Kitching AR, Kong YZ, Huang XR, et al. Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis. J Am Soc Nephrol. 2003 Jun;14(6):1487-95.
  38. Timoshanko JR, Holdsworth SR, Kitching AR, Tipping PG. IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J Immunol. 2002 Apr 15;168(8):4135-41.
  39. Kitching AR, Ru Huang X, Turner AL, Tipping PG, Dunn AR, Holdsworth SR. The requirement for granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in leukocyte-mediated immune glomerular injury. J Am Soc Nephrol. 2002 Feb;13(2):350-8.
  40. Kitching AR, Katerelos M, Mudge SJ, Tipping PG, Power DA, Holdsworth SR. Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis. Clin Exp Immunol. 2002 Apr;128(1):36-43.
  41. Kitching AR, Huang XR, Ruth AJ, Tipping PG, Holdsworth SR. Effects of CTLA4-Fc on glomerular injury in humorally-mediated glomerulonephritis in BALB/c mice. Clin Exp Immunol. 2002 Jun;128(3):429-35.