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Monash Centre for Inflammatory Diseases

Dr Michael Hickey

Dr Michael Hickey

Dr. Michael Hickey is an NHMRC Senior Research Fellow.  His laboratory examines leukocyte recruitment in inflamed tissues, a process which underlies the pathogenesis of most inflammatory diseases.  His research examines the control of leukocyte-endothelial cell interactions and leukocyte migration in the inflamed microvasculature, using intravital (in vivo) microscopy to examine the functional microvasculature in models of inflammation.  Current diseases examined include contact sensitivity, glomerulonephritis, systemic lupus erythematosus, arthritis and cerebral inflammation.  An additional focus is human endothelial cell biology.

Publications 2002-2008

  1. Wong CH, Bozinovski S, Hertzog PJ, Hickey MJ, Crack PJ. Absence of Glutathione Peroxidase-1 (Gpx1) Exacerbates Cerebral Ischemia-Reperfusion Injury by Reducing Post-Ischemic Microvascular Perfusion. J Neurochem. 2008 Aug 7.
  2. Norman MU, James WG, Hickey MJ. Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr mice. J Leukoc Biol. 2008 Jul;84(1):68-76.
  3. Kitching AR, Holdsworth SR, Hickey MJ. Targeting leukocytes in immune glomerular diseases. Curr Med Chem. 2008;15(5):448-58.
  4. Hickey MJ, Kwan RY, Awad MM, Kennedy CL, Young L F, Hall, P, Cordner L, Lyras D, Emmins JJ, Rood JI.  Molecular and cellular basis of microvascular perfusion deficits induced by Clostridium perfringens and Clostridium septicum. PLoS Pathog. 2008 Apr;4(4):e1000045.
  5. Ayoub S, Hickey MJ, Morand EF. Mechanisms of disease: macrophage migration inhibitory factor in SLE, RA and atherosclerosis. Nat Clin Pract Rheumatol. 2008 Feb;4(2):98-105.
  6. Apostolopoulos J, Hickey MJ, Sharma L, Davenport P, Moussa L, James WG, Gregory JL, Kitching AR, Li M, Tipping PG.  The cytoplasmic domain of tissue factor in macrophages augments cutaneous delayed-type hypersensitivity. J Leukoc Biol. 2008 Apr;83(4):902-11.
  7. Yipp BG, Hickey MJ, Andonegui G, et al. Differential roles of CD36, ICAM-1, and P-selectin in Plasmodium falciparum cytoadherence in vivo. Microcirculation. 2007 Aug;14(6):593-602.
  8. Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koener RR, Dewor M, Georgiev I, Schober A, Leng L, Kooistra T, Finderle-Rowson G, Ghezzi P, Kleemann R, McColl SR, Bucala R, Hickey MJ, Weber C. MIF is a functional ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.  Nature Medicine (2007) 13: 587-596
  9. LIster KJ, James WG, Hickey MJ.  Immune complexes mediate rapid alterations in microvascular permeability: roles for neutrophils, complement and platelets.  Microcirculation (2007) In press, accepted 24/2/2007.
  10. Sasmono RT, Ehrnsperger A, Cronau SL, Ravasi T, Kandane R, Hickey MJ, Cook AD, Himes SR, Hamilton JA, Hume DA.  Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts, and can transdifferentiate into macrophages in vitro in response to CSF-1.  J. Leukoc. Biol. (2007) Apr 16.
  11. He X, Schoeb TR, Panoskaltsis-Mortari A, Zinn KR, Kesterson RA, Zhang J, Samuel S, Hicks MJ, Hickey MJ, Bullard DC. Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads toaccelerated development of glomerulonephritis and increased expression of CCchemokine ligand 2 in lupus-prone mice. JImmunol. 2006 Dec 15;177(12):8748-56.
  12. Gregory JL, Morand EF, McKeown SJ, Ralph JA, Hall P, Yang YH, McColl SR, Hickey MJ.Macrophage migration inhibitory factor induces macrophage recruitment via CC chemokine ligand 2. J Immunol. 2006 Dec 1;177(11):8072-9.
  13. Hoi AY, Hickey MJ, Hall P, Yamana J, O'Sullivan KM, Santos LL, James WG, Kitching AR, Morand EF. Macrophage migration inhibitory factor deficiency attenuates macrophage recruitment, glomerulonephritis, and lethality in MRL/lpr mice. J Immunol. 2006 Oct 15;177(8):5687-96.
  14. Ruth AJ, Kitching AR, Kwan RY, Odobasic D, Ooi JD, Timoshanko JR, Hickey MJ, Holdsworth SR.Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis. J Am Soc Nephrol. 2006 Jul;17(7):1940-9.
  15. Goschnick MW, Lau LM, Wee JL, Liu YS, Hogarth PM, Robb LM, Hickey MJ, Wright MD, Jackson DE. Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice. Blood. 2006 Sep 15;108(6):1911-8.
  16. Kuligowski MP, Kitching AR, Hickey MJ. Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin in the absence of rolling. J Immunol. 2006 Jun 1;176(11):6991-9.
  17. James WG, Hutchinson P, Bullard DC, Hickey MJ. Cerebral leucocyte infiltration in lupus-prone MRL/MpJ-fas lpr mice--roles of intercellular adhesion molecule-1 and P-selectin. Clin Exp Immunol. 2006 May;144(2):299-308.
  18. Lister KJ, Hickey MJ. Immune complexes alter cerebral microvessel permeability: roles of complement and leukocyte adhesion. Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H694-704.
  19. Norman MU, Hickey MJ. Mechanisms of lymphocyte migration in autoimmune disease. Tissue Antigens. 2005 Sep;66(3):163-72.
  20. Norman MU, Lister KJ, Yang YH, Issekutz A, Hickey MJ. TNF regulates leukocyte-endothelial cell interactions and microvascular dysfunction during immune complex-mediated inflammation. Br J Pharmacol. 2005 Jan;144(2):265-74.
  21. Kerfoot SM, Long EM, Hickey MJ, Andonegui G, Lapointe BM, Zanardo RC, Bonder C, James WG, Robbins SM, Kubes P. TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. J Immunol. 2004 Dec 1;173(11):7070-7.
  22. Gregory JL, Leech MT, David JR, Yang YH, Dacumos A, Hickey MJ. Reduced leukocyte-endothelial cell interactions in the inflamed microcirculation of macrophage migration inhibitory factor-deficient mice. Arthritis Rheum. 2004 Sep;50(9):3023-34.
  23. Sharma L, Melis E, Hickey MJ, Clyne CD, Erlich J, Khachigian LM, Davenport P, Morand E, Carmeliet P, Tipping PG. The cytoplasmic domain of tissue factor contributes to leukocyte recruitment and death in endotoxemia. Am J Pathol. 2004 Jul;165(1):331-40.
  24. Norman MU, Van De Velde NC, Timoshanko JR, Issekutz A, Hickey MJ. Overlapping roles of endothelial selectins and vascular cell adhesion molecule-1 in immune complex-induced leukocyte recruitment in the cremasteric microvasculature. Am J Pathol. 2003 Oct;163(4):1491-503.
  25. Hickey MJ. Alterations in leucocyte trafficking in lupus-prone mice: an examination of the MRL/faslpr mouse. Immunol Cell Biol. 2003 Oct;81(5):390-6.
  26. Norman MU, Lew RA, Smith AI, Hickey MJ. Metalloendopeptidases EC 3.4.24.15/16 regulate bradykinin activity in the cerebral microvasculature. Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H1942-8.
  27. James WG, Bullard DC, Hickey MJ. Critical role of the alpha 4 integrin/VCAM-1 pathway in cerebral leukocyte trafficking in lupus-prone MRL/fas(lpr) mice. J Immunol. 2003 Jan 1;170(1):520-7.
  28. Hickey MJ, Sihota E, Amrani A, Santamaria P, Zbytnuik LD, Ng ES, Ho W, Sharkey KA, Kubes P.Inducible nitric oxide synthase (iNOS) in endotoxemia: chimeric mice reveal different cellular sources in various tissues. FASEB J. 2002 Jul;16(9):1141-3.
  29. Hickey MJ, Bullard DC, Issekutz A, James WG. Leukocyte-endothelial cell interactions are enhanced in dermal postcapillary venules of MRL/fas(lpr) (lupus-prone) mice: roles of P- and E selectin. J Immunol. 2002 May 1;168(9):4728-36.
Platelets (white) accumulating in inflamed glomeruli Adherent neutrophils (red) CD4 T cells (green) and CD8 T cells (blue) in a dermal venule during a contact sensitivity response
Platelets (white) accumulating in inflamed glomeruli Adherent neutrophils (red) CD4 T cells (green) and CD8 T cells (blue) in a dermal venule during a contact sensitivity response