Monash Centre for Inflammatory Diseases

Professor Phil Bardin

Phil Bardin is Professor of Respiratory Medicine in the Faculty of Medicine, Nursing & Health Sciences, Monash University, Melbourne. He is recognised nationally and internationally for research of virus-asthma exacerbations and has conducted extensive research of clinical asthma therapies and treatment. Recently, investigations of vocal cord dysfunction in asthma have come to national and international prominence.  Since 2008 he has been Director, Lung and Sleep Medicine, Monash University and Medical Centre, Melbourne.

Professor Bardin has demonstrated sustained research income (NH&MRC) and publication productivity (>80 peer-reviewed papers) in high impact journals. His work reflects a career-long commitment to the area of asthma and has forged several key collaborations within the Monash basic science framework and the Australian respiratory research community. In addition to an extensive network of collaborations locally, nationally, and internationally in North America and Europe, close links to the MRC Asthma Research Group in Southampton are maintained where he holds an honorary professorial position.

Currently he is Deputy Editor and Editor-in-chief elect for Respirology, official journal of the TSANZ and the APSR. In addition he has chaired the Asthma and Allergy Special Interest Group.  Since 2004 he has served on the NH&MRC Grant Review Panel (Respiratory & Sleep Medicine) and has been chairman of the 2009 NH&MRC 3C Respiratory & Sleep Medicine Grant Review Panel. In 2010 he served on the NH&MRC Academy.

Publications

1.                   Laryngeal penetration and aspiration in stable COPD. Cvejic L, Harding R, Churchward T, Turton A, Finlay P, Massey D, Bardin PG, Guy P. Respirology. 2010 [Epub ahead of print].

2.                   Excessive airway collapse diagnosed using 320-slice CT scanning. Joosten S, Macdonald M, Lau KK, Bardin P, Hamilton G. Thorax. 2010 Jul 7. [Epub ahead of print]

3.                   Allergy is an important factor in asthma exacerbation: a pro-con debate. Custovic A, Simpson A, Bardin PG, Le Souëf P. Respirology. 2010; 15: 1021-7.

4.                   Holmes PW, Lau KK, Crossett M, Low C, Buchanan D, Hamilton GS, Bardin PG. Diagnosis of vocal cord dysfunction in asthma with high resolution dynamic volume computerized tomography of the larynx. Respirology. 2009; 14: 1106-13.

5.                   Calverley PM, Rabe KF, Goehring UM, Kristiansen S, Fabbri LM, Martinez FJ; M2-124 and M2-125 study groups (Bardin PG). Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. Lancet. 2009; 374: 685-94.

6.                   Gary Lee YC, Bardin P. Impact factor and its role in academic promotion. Respirology. 2009; 14: 914.

7.                   MacDonald M, Bardin P. "Temporal clustering" of COPD exacerbations may reflect corticosteroid withdrawal. Am J Respir Crit Care Med. 2009; 180: 482-3.

8.                   Ghildyal R, Li D, Bardin PG, Gern JE, Jans DA. Rhinovirus 3C can localise in the nucleus and alter nucleocytoplasmic transport. J Virol. 2009; 83: 7349-52.

9.                   Seale JP, Jenkins C, Wood-Baker R, Neville AM; Asthma Management Advisory Board (Bardin PG). Benefits of fixed-dose combination therapy with inhaled corticosteroids and long-acting bronchodilators as initial maintenance therapy in the management of asthma. Respirology 2009; 14: 224-9.

10.               Thomas BJ, Lindsay M, Dagher H, Freezer NJ, Li D, Ghildyal R, Bardin PG. Transforming growth factor-β enhances rhinovirus infection by diminishing early innate responses. Am J Resp Cell Mol Biol 2009 2009; 41: 339-47.

11.               Calderon C, Rivera L, Hutchinson P, Dagher H, Ghildyal R, Bardin PG, Freezer NJ. T cell cytokine profiles during asthma exacerbation. Respirology 2009; 14: 264-9.

12.               Vestbo J, Tan L, Atkinson G, Ward J; UK-500,001 Global Study Team (Bardin PG). A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD. Eur Respir J. 2009; 33: 1039-44.

13.               Ruffin RE, Bardin PG. Respirology year-in-review 2008: Clinical science. Respirology 2009; 14: 159-66.

14.               Miller A, Strauss BJ, Mol S, Kyoong A, Holmes P, Finlay P, Bardin PG, Guy P. Dual Energy X-ray Absorptiometry (DEXA) is the method of choice to assess body composition in COPD. Respirology 2009; 14: 411-8.

15.               Li DS; Jans DA; Bardin PG; Meanger J; Mills J; Ghildyal R. Association of respiratory syncytial virus M protein with viral nucleocapsids is mediated by the M2-1 protein. J. Virol 2008; 82: 8863-70.

16.               Charles PG, Wolfe R, Whitby M, Fine MJ, Fuller AJ, Stirling R, Wright AA, Ramirez JA, Christiansen KJ, Waterer GW, Pierce RJ, Armstrong JG, Korman TM, Holmes P, Obrosky DS, Peyrani P, Johnson B, Hooy M; Australian Community-Acquired Pneumonia Study Collaboration (Bardin PG). Clin Infect Dis. 2008 1; 47: 375-84.

17.               Obihara CC, Bardin PG. Hygiene hypothesis, allergy and BCG: a dirty mix? Clin Exp Allergy 2008; 38:388-92.

18.               Charles PG, Whitby M, Fuller AJ, Stirling R, Wright AA, Korman TM, Holmes PW, Christiansen KJ, Waterer GW, Pierce RJ, Mayall BC, Armstrong JG, Catton MG, Nimmo GR, Johnson B, Hooy M, Grayson ML; Australian CAP Study Collaboration (Bardin PG). Clin Infect Dis. 2008 15; 46:1513-21

19.               Ruffin R, Bardin PG. Respirology year-in-review 2007: Clinical science. Respirology 2008; 13:170-80.

20.               Bardin PG. Treatment of obstructive airways diseases with roflumilast, a novel phosphodiesterase-4 inhibitor. Expert Rev Clin Immunol 2007; 3: 469-476

21.               Pryor MJ, Rawlinson SM, Butcher RE, Barton CL, Waterhouse TA, Vasudevan SG, Bardin PG, Wright PJ, Jans DA, Davidson AD. Nuclear Localization of Dengue Virus Nonstructural Protein 5 Through Its Importin alpha/beta-Recognized Nuclear Localization Sequences is Integral to Viral Infection. Traffic 2007; 8:795-807.

22.               Louw C, Williams Z, Venter L, Leichtl S, Schmidt-Wirlitsch C, Bredenbroker D, Bardin PG. Roflumilast, a phosphodiesterase inhibitor, reduces airway hyperresponsiveness after allergen challenge. Respiration. 2007; 74(4):411-7.

23.               J Rimmer, HL Peake, CM Santos, M Lean, P Bardin, R Robson, B. Haumann, F Loehrer, ML Handel. Targeting adenosine receptors in the treatment of allergic rhinitis: a randomized, double-blind, placebo-controlled study. Clin Exp Allergy 2007; 37:8-14.

24.               Kyoong A, Mol S, Guy P, Finlay P, Strauss BJ, Holmes P, Bardin PG. Comparison of Australian and international guidelines for grading severity of chronic obstructive pulmonary disease. Intern Med J. 2006; 36:506-12.

25.               Van der Merwe L, de Klerk A, Kidd M, Bardin PG, van Schalkwyk EM. Case-control study of severe life threatening asthma (SLTA) in a developing community. Thorax. 2006; 61:756-60.

26.               Maclennan C, Hutchinson P, Holdsworth S, Bardin PG, Freezer NJ. Airway inflammation in asymptomatic children with wheeze. Pediatr Pulmonol. 2006; 41:577-83.

27.               De Silva D, Dagher H, Ghildyal R, Lindsay M, Li X, Freezer NJ, Wilson JW, Bardin PG. Vascular endothelial growth factor induction by rhinovirus infection. J Med Virol. 2006; 78:666-672

28.               Ghildyal R, Ho A, Wagstaff KM, Barton CA, Jans P, Bardin PG, Jans DA. Importin β1 mediates nuclear import of the RSV matrix protein independent of importin α. Biochemistry 2005; 44: 1287-95.

29.               Van Schalkwyk EM, Strydom K, Williams Z, Venter L, Leichtl S, Schmid-Wirlitsch C, Bredenbroeker D, Bardin PG. Roflumilast, an oral PDE4 inhibitor attenautes allergen-induced asthmatic reactions. J Allergy Clin Immunol 2005; 116: 292-98.

30.               Ghildyal R, Li D, Peroulis I, Shields I, Bardin PG, Teng MN, Collins PL, Meanger J, Mills J. Interaction between RSV G glycoprotein cytoplasmic domain and the matrix protein. J Gen Virol 2005;86: 1879-84.

31.               Kling S, Donninger H, Williams Z, Vermeulen J, Weinberg E, Latiff K, Ghildyal R, Bardin PG. Persistence of rhinovirus RNA after asthma exacerbation in children. Clin Exp Allergy 2005; 35: 672-78.

32.               Ghildyal R, Dagher H, Donninger H, De Silva D, Li X, Freezer NJ, Wilson JW, Bardin PG. Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and a permeability factor. J Med Virol. 2005; 75: 608-15.

33.               Lyell P, Villaneuva E, Freezer NJ, Bardin PG. Risk factors for intensive care in children with acute asthma. Respirology 2005; 10: 436-41.

34.               Bardin PG. Inoculation for asthma exacerbations. Intern Med J 2004; 34: 358-60.

35.               Dagher H, Donninger H, Hutchinson P, Ghildyal R, Bardin PG. Rhinovirus detection: comparison of real-time and conventional PCR. J Virol Methods 2004; 117: 113-21.

36.               Donninger H, Glashoff R, Haitchi H-M, Syce JA, Ghildyal R, van Rensburg E, Bardin PG. Rhinovirus induction of the CXC Chemokine ENA-78 in bronchial epithelium. J Infect Dis. 2003 Jun 1; 187(11):1809-17.

37.               Watson M, Beasley RW, Holgate ST, Bardin PG. Rhinovirus is not detectable in peripheral lung tissue after asthma death. Respirology 2003 Jun;8(2):234-238.

38.               Fenhalls G, Stevens L, Bezuidenhout J, Warren R, Bardin PG. Localisation of Mycobacterial DNA and RNA in human tuberculous granulomas. J Microb Methods 2002; 51: 197-208

39.               Ferreira A, Williams Z, Donniger H, van Schalkwyk EM, Bardin PG. Rhinovirus is associated with severe asthma exacerbations and raised nasal interleukin-12. Respiration 2002; 69: 136-42.

40.               De Klerk A, van Schalkwyk EM, Williams Z, Lee W, Bardin PG. Risk factors for near-fatal asthma: a case-control study in the Western Cape, SA. S Afr Med J 2002; 92: 140-4.

41.               Seymour ML, Gilby N, Bardin PG, Fraenkel DJ, Sanderson G, Penrose JF, Holgate ST, Johnston SL, Sampson AP. Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects. J Infect Dis 2002; 185: 540-44.

42.               Fenhalls G, Stevens L, Bezuidenhout J, Amphett G, Duncan K, Bardin P, Lukey P. Distribution of IFN-gamma, IL-4 and TNF-alpha protein and CD8 T-cells producing IL-12p40 mRNA in human lung tuberculous granulomas.  Immunology 2002; 105: 325-335.

43.               Mattheyse FJ, van Heerden K, Mattheyse M, Williams Z, Bouic P, van Schalkwyk EM, Bardin PG. Reduced activation of peripheral blood neutrophils after late phase asthmatic responses but not in mild stable asthma. Respiration 2001; 68: 471-79.

44.               Nell H, Cyster H, Louw H, Bardin PG, Joubert JR. Evaluation of two BDP preparations for the management of chronic asthma. S Afr Med J 2001; 91: 51-6.

45.               Lalloo U, Bateman ED, Feldman C, Bardin PG, Plit M, Irusen E, O’Brien J. Guidelines for the management of chronic asthma in adults: 2000 update. S Afr Med J 2000; 90: 544-52.

46.               Bardin PG, Fraenkel DJ, Sanderson G, van Schalkwyk EM, Holgate ST, Johnston SL.  Peak Expiratory Flow changes during experimental Rhinovirus infection.  Eur Resp J 2000; 16: 980-85.

47.               Van Dyk C, Biebuyk T, Van der Merwe M, Bardin PG, Bolliger CT. Haemotysis in a patient with a pulmonary mass and previous tuberculosis. Respiration 2000; 68: 331-3.

48.               Papadopoulos N, Bates PJ, Bardin PG, Papi A, Fraenkel DJ, Lackie PM, Holgate ST, Johnston SL.  Rhinoviruses infect the lower airway.  J Infect Dis 2000; 181: 1875-84.

49.               Fenhalls G, Bezuidenhout J, Schneider JW, Bardin PG, Lukey PT. In situ production of gamma interferon, interleukin-4 and tumor necrosis factor alpha mRNA in human lung tuberculous granulomas.  Infect Immun 2000; 68:2827-2836.