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Monash Centre for Inflammatory Diseases

Associate Professor Phil Bardin

Associate Professor Phil Bardin

Associate Professor Phil Bardin obtained a PhD from Southampton University (UK) working under Stephen Holgate, an eminent researcher in allergy and asthma. His field of study was viruses (particularly rhinovirus), their interaction with asthma and role in exacerbations. In 2000, he accepted a position as Director of Respiratory Research at Monash Medical Centre and commissioned a virus research laboratory. The laboratory is one of only a handful worldwide that is able to conduct studies of RV and its impact on allergic diseases. Recent research has also included studies of RSV in collaboration with David Jans at Monash University and innate immune responses with Bryan Williams at Monash Institute of Medical Research.

Associate Professor Bardin developed one of the first PCR assays for rhinovirus and was principal author of the first research paper to report detection of rhinovirus in human tissues using in situ hybridisation. He initiated studies to confirm infection by rhinovirus of the lower airways, a key issue for further research in this field. Recently a key neutrophil chemokine (ENA-78) released by airway epithelium in response to RV was characterised by the Monash laboratory and replicative rhinovirus infection of fibroblasts was verified.

Associate Professor Bardin has held 15 research grants since 1994 from various government (UK, South Africa, Australia), charitable (Rebecca L Cooper Research Foundation, Asthma Victoria) and industrial sources (Glaxo-Wellcome, ALLSA-UCB, Boehringer-Ingelheim, Schering-Plough). Total research dollars approximately $900,000 overall in 14 years and $355,000 in Australia since 2001. NH&MRC CJ Martin Fellowship, with funding in USA for 2 years (2004, 2005) and funding at Monash for 3 years (2006 – 2008). CHATA ‘near-miss NH&MRC’ funding 2005. NH&MRC grant (with David Jans) for studies of RSV pathogenesis (2007-2009; $470,000).

He is a member of the Thoracic Society of Australia and New Zealand; European Respiratory Society; American Thoracic Society. Serves on the Editorial Board of Respiration and as a reviewer for Am J Resp Cell Mol Biol, Clin Exp Allergy, Eur Resp J and Thorax. Associate Editor, Respirology.

Publications 2002 - 2008

  1. Ruffin R, Bardin PG. Respirology year-in-review 2007: Clinical science. Respirology. 2008 Mar;13(2):170-80.
  2. Obihara CC, Bardin PG. Hygiene hypothesis, allergy and BCG: a dirty mix? Clin Exp Allergy. 2008 Mar;38(3):388-92.
  3. Li D, Jans DA, Bardin PG, Meanger J, Mills J, Ghildyal R. Association of respiratory syncytial virus m protein with viral nucleocapsids is mediated by the m2-1 protein. J Virol. 2008 Sep;82(17):8863-70.
  4. Rosenblut A, Bardin PG, Muller B, et al. Long-term safety of fluticasone furoate nasal spray in adults and adolescents with perennial allergic rhinitis. Allergy. 2007 Sep;62(9):1071-7.
  5. Pryor MJ, Rawlinson SM, Butcher RE, Barton CL, Waterhouse TA, Vasudevan SG, Bardin PG, Wright PJ, Jans DA, Davidson AD.  Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection. Traffic. 2007 Jul;8(7):795-807.
  6. Louw C, Williams Z, Venter L, Leichtl S, Schmid-Wirlitsch C, Bredenbroker D, Bardin PG. Roflumilast, a phosphodiesterase 4 inhibitor, reduces airway hyperresponsiveness after allergen challenge. Respiration. 2007;74(4):411-7.
  7. van der Merwe L, de Klerk A, Kidd M, Bardin PG, van Schalkwyk EM. Case-control study of severe life threatening asthma (SLTA) in a developing community. Thorax. 2006 Sep;61(9):756-60.
  8. Kyoong A, Mol S, Guy P, Finlay P, Strauss BJ, Holmes P, Bardin PG. Comparison of Australian and international guidelines for grading severity of chronic obstructive pulmonary disease. Intern Med J. 2006 Aug;36(8):506-12.
  9. Maclennan C, Hutchinson P, Holdsworth S, Bardin PG, Freezer NJ.Airway inflammation in asymptomatic children with episodic wheeze. Pediatr Pulmonol. 2006 Jun;41(6):577-83.
  10. De Silva D, Dagher H, Ghildyal R, Lindsay M, Li X, Freezer NJ, Wilson JW, Bardin PG.Vascular endothelial growth factor induction by rhinovirus infection. J Med Virol. 2006 May;78(5):666-72.
  11. Lyell PJ, Villanueva E, Burton D, Freezer NJ, Bardin PG. Risk factors for intensive care in children with acute asthma. Respirology. 2005 Sep;10(4):436-41.
  12. van Schalkwyk E, Strydom K, Williams Z, Venter L, Leichtl S, Schmid-Wirlitsch C, Bredenbroker D, Bardin PG. Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions. J Allergy Clin Immunol. 2005 Aug;116(2):292-8.
  13. Ghildyal R, Li D, Peroulis I, Shields B, Bardin PG, Teng MN, Collins PL, Meanger J, Mills J.Interaction between the respiratory syncytial virus G glycoprotein cytoplasmic domain and the matrix protein. J Gen Virol. 2005 Jul;86(Pt 7):1879-84.
  14. Ghildyal R, Dagher H, Donninger H, de Silva D, Li X, Freezer NJ, Wilson JW, Bardin PG. Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and a permeability factor. J Med Virol. 2005 Apr;75(4):608-15.
  15. Bardin PG.Vaccination for asthma exacerbations. Intern Med J. 2004 Jun;34(6):358-60.
  16. Watson MW, Beasley R, Holgate ST, Bardin PG. Rhinovirus is not detectable in peripheral lung tissue after asthma death. Respirology. 2003 Jun;8(2):234-8.
  17. Donninger H, Glashoff R, Haitchi HM, Syce JA, Ghildyal R, van Rensburg E, Bardin PG. Rhinovirus induction of the CXC chemokine epithelial-neutrophil activating peptide-78 in bronchial epithelium. J Infect Dis. 2003 Jun 1;187(11):1809-17.
  18. Ferreira A, Williams Z, Donninger H, van Schalkwyk EM, Bardin PG. Rhinovirus is associated with severe asthma exacerbations and raised nasal interleukin-12. Respiration. 2002;69(2):136-42.
  19. Seymour ML, Gilby N, Bardin PG, Fraenkel DJ, Sanderson G, Penrose JF, Holgate ST, Johnston SL, Sampson AP. Rhinovirus infection increases 5-lipoxygenase and cyclooxygenase-2 in bronchial biopsy specimens from nonatopic subjects. J Infect Dis. 2002 Feb 15;185(4):540-4.