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Assessment of knee joint articular cartilage volume change in women with breast cancer treated with anastrozole or letrozole and comparison with untreated controls
Recruitment Closed
Principal Researchers
Many women with breast cancer are treated with a class of drugs called aromatase inhibitors (mainly letrozole or anastrozole) which lower the amount of oestrogen being produced in the body. Women on aromatase inhibitors appear to experience joint pains and arthralgia. The mechanism of increased bone loss and fracture risk in women on aromatase inhibitors is clearly related to the depletion of oestrogen production in the bone. However, why there is a higher rate of reporting of joint pain amongst women on aromatase inhibitors is not fully understood. We are conducting a study to determine whether the joint pains experienced by some women on aromatase inhibitors is associated with more defects in their cartilage, compared to women not receiving this therapy.
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