Antonia Miller

Current Position:
Research Officer

Phone:
+ 61 3 9903 0676

Facsimile:
+ 61 3 9903 0038

Email:
Antonia.Miller@med.monash.edu.au

Office:
1U30, Department of Immunology
Level 1, Monash University Building, AMREP
Commercial Road
Melbourne 3004

Biosketch:
I completed my doctoral studies in biochemistry at the University of Canterbury in New Zealand in 2004. I then commenced a post-doctoral fellowship at Case Western Reserve University in Cleveland, USA, where I became interested in diabetic retinopathy.  These later studies focused on the role of the protection of retinal pericytes against apoptosis, the later being a key step in early diabetic retinopathy.

Current Research Focus:
The increasing prevalence of diabetes has hastened the need for a more complete understanding of the complications arising from diabetes. Diabetic retinopathy, which can in some cases result in blindness, is one such complication. I have a special interest in understanding the biochemistry underlying the vascular pathology observed during diabetic retinopathy.

Selected Publications:
Miller AG, Smith DG, Bhat M, Nagaraj, R. Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions. J Biol. Chem., 2006, 281, (17): 11864-11871.

Biswas, A, Miller AG, Oya-Ito T, Santhoshkumar P, Bhat M, Nagaraj R, Effect of site-directed mutagenesis of methylglyoxal-modifiable arginine residues on the structure and function of human alpha a crystallin. Biochemistry, 2006, 45, (14):4569-4577.

Miller AG, Hegge S, Uhlmann A, Gerrard JA, A continuous enzyme assay and characterisation of fructosyl amine oxidase enzymes (EC 1.5.3). Arch. Biochem. Biophys., 2005, 434(1):60-6

Miller AG, Meade SJ, Gerrard JA, New insights into protein crosslinking via the Maillard reaction: structural requirements, the effect on enzyme function, and predicted efficacy of crosslinking inhibitors as anti-ageing therapeutics. Bioorg. Med. Chem., 2003,11(6):843-52