Clinical Pharmacology Unit

Department of Epidemiology and Preventive Medicine

Head: Professor Henry Krum

The Clinical Pharmacology Unit conducts mechanistic trials of new and existing drug therapies. It also serves as a coordinating centre for multi-centre clinical trials.

The unit is part of the new Monash Centre of Cardiovascular Research and Education in Therapeutics directed by Prof Krum.

Staff

• Jane Brack (Alfred)
• Robyn Funston (Alfred)
• Joanne Harwood
• Andrew Kompa (Dept of Medicine)
• Marina Skiba BEd(Sec)Sci
• Emma Windebank (Alfred)

Doctoral students

• Stephen Haas
• Will Kemp
• Hendrik Zimmet
• Maros Elsik
• Michele McGrady
• Pupalan Iyngkaran

Research

• UNIVERSE - study of statin therapy in the treatment of heart failure
• CHABLIS - study of addition of ARB versus increasing the dose of ACE inhibitor in patients with systolic heart failure.
• COLA II - prospective open-label study of tolerability of administration of the beta-blocker, carvedilol, to elderly patients with heart failure.

The unit also conducts a number of basic research programs. Current programs include -

• Role of urotensin II in cardiac disease (NHMRC supported)
• Role of p38 MAP kinase system in heart failure disease progression
• Anti-fibrotic effects of statin therapies in cardiac cells.