Clinical Epidemiology Unit

Pilot study of fungal avoidance

Assoc Prof Michael Abramson

Dr Shyamali Dharmage
Dr Frank Thien
Prof E.Haydn Walters

Funded by: Alfred Research Trusts

Asthma is now a national health priority. Many people with asthma are allergic to house dust mites and fungi. Studies of
house dust mite allergen avoidance have provided conflicting results. One study suggested that indoor fungal exposures
could be reduced, but the clinical benefits of this are unknown. We have conducted a pilot study of fungal avoidance in
asthmatic subjects with fungal allergy. This involved removing accumulated mould from homes and preventing regrowth by
regularly cleaning mouldy surfaces with bleach and reducing indoor humidity. This pilot study will determine the feasibility
and facilitate the design of a more definitive randomised controlled trial. If such a trial is successful, it would enable the
National Asthma Council to educate patients, their families and doctors concerning appropriate measures and interventions to minimise allergen exposure and reduce the risk of asthma attacks. If unsuccessful, resources can be redirected into other areas of asthma prevention.

The pilot study has now been completed and the data are currently being analysed.