Anaesthesia and Perioperative Medicine research activities
The research unit is headed by Professor Paul Myles, and funded through a number of large NHMRC grants. Paul is supported by an NHMRC Practitioner Fellowship.
The unit is staffed by:
- Sophie Wallace, Research Manager
- Andrea Ditoro, Research Assistant
- Catherine Farrington, Research Assistant
- Wendy Gallagher, Research Assistant
- Christina Halstead, Research Assistant
- Jennifer Hunt, Research Assistant
Current research trials and studies
The unit manages and participates in numerous multicentre and local clinical trials and studies at any one time.
Aspirin and Tranexamic Acid for Coronary Artery Surgery Trial
Nitrous oxide anaesthesia and cardiac morbidity after major surgery
Restrictive versus Liberal Fluid therapy in major abdominal surgery
POISE 2 is a large, international, placebo-controlled, factorial trial to assess the impact of clonidine and acetyl-salicylic acid (ASA) in patients undergoing noncardiac surgery who are at risk of a perioperative cardiovascular event.
The influence of anaesthetic depth on patient outcome after major surgery
Recovery after Major Surgery
Recovery and Well-being after Major Surgery: complications, functional recovery, and the measurement of disability-free survival. Recruiting 500 sequential patients from four centres, coordinated at the Department of Anaesthesia and Perioperative Medicine, Alfred Hospital. Funded through ANZCA
Measurement of Exercise Tolerance for Surgery (METS) Study
To compare preoperative CPET to physicians’ subjective assessment of functional capacity for predicting postoperative 30-day death or non-fatal myocardial infarction in patients undergoing major elective non-cardiac surgery.
Intravenous Iron to reduce transfusion and improve post-operative haemoglobin in patients with fractured Neck of Femur
To reduce the burden of red blood cell transfusion in patients with fractured neck of femur by the use of intravenous iron transfusion.
Limiting I.V. Chloride to Reduce Acute kidney injury
The LICRA study aims to test the impact of a strategy of perioperative chloride-restriction through intravenous (IV) fluid therapy on the incidence of acute kidney injury after cardiac surgery. LICRA is a prospective, open-label, single-centre 4-period sequential study including all patients undergoing surgery by the Department of Cardiothoracic Surgery within the study period. Available IV fluids are categorized as either chloride-rich or chloride-poor and the study involves a unit-wide policy switch in the type of administered intravenous fluid according to pre-defined calendar dates.
International Surgical Outcomes Study
The primary outcome measure is in-hospital all cause mortality at 30 days following surgery. The secondary outcome measures are number of admissions to critical care and duration of hospital stay.
Proteolytic Mechanisms of Chronic Pain: Research Translation
The aim is to identify the body chemicals and proteins that play a key causative role in certain types of pain that people in hospital experience. These types of pain that we will focus on include nerve pain (neuropathic pain) and pain associated with significant tissue inflammation.
In addition, registrars receive specialist training in Anaesthesia, and each registrar must complete a research project as part of their specialist qualifications. During 2013, seven projects were completed, including randomised trials and audits.