SELECTED PUBLICATIONS

1. CANCER

Flint, A.J., Tiganis, T., Barford, D., & Tonks, N.K. (1997) Development of ‘substrate trapping' mutants to identify physiological substrates of protein tyrosine phosphatases. Proc. Natl. Acad. Sci. USA 94, 1680-1685. (2003 IF = 10.2)

Tiganis, T., Bennett, A.M., Ravichandran, K.S., & Tonks, N.K. (1998) Epidermal growth factor receptor & the adaptor protein p52^Shc are specific substrates of the T-cell protein tyrosine phosphatase. Mol. Cell. Biol. 18, 1622-1634. (2003 IF = 8.1)

Klingler-Hoffmann, M., Fodero-Tavoletti, T.M., Mishima, K., Narita, Y., Cavenee, W., Furnari, F.B., Huang, S.H.-J., & Tiganis, T. (2001) The protein tyrosine phosphatase TCPTP suppresses the tumourigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor. J. Biol. Chem. 276, 46313-46318. (2003 IF = 6.5)

Shields, B., Hauser, C., Bukczynska. P.E. Court N.W., & Tiganis, T. (2008) DNA replication stalling attenuates tyrosine kinase signalling to suppress S-phase progression. Cancer Cell. 14, 166-179. (2007 IF 24.1)

See press releases:
www.med.monash.edu.au/news/2008/cancer-survival.html

http://news.theage.com.au/national/secrets-of-cancer-survival-revealed-20080812-3tp4.html

http://monash.yourguide.com.au/news/local/news/general/research-blooms/1246981.aspx

2. DIABETES & OBESITY

Galic, S., Klingler-Hoffmann, M., Fodero-Tavoletti, T.M., Puryer, M.A., Meng, T.-C., Tonks, N.K., & Tiganis, T. (2003) Regulation of insulin receptor signalling by the protein tyrosine phosphatase TCPTP. Mol. Cell. Biol. 23, 2096-2108. (2003 IF = 8.1)

Meng, T.C., Buckley D.A., Galic, S.A., Tiganis, T., & Tonks, N.K (2004) Regulation of insulin signaling through reversible oxidation of the protein tyrosine phosphatases TC45 & PTP1B. J. Biol. Chem. 279, 37716-25. (2004 IF = 6.4)

Galic, S., Hauser, C., Kahn, B.B., Haj, F.G., Neel, B.G., Tonks, N.K., & Tiganis, T. (2005) Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B & TCPTP. Mol Cell Biol. 25, 819-29. (2003 IF = 8.1)

Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B.J., Skiba B., Ooms L., Stepto, N., Wu, B., Mitchell, C.A., Tonks, N.K., Watt, M.J., Febbraio, M.A., Crack, P.J., Andrikopoulos, S., & Tiganis, T. (2009) Reactive oxygen species enhance insulin sensitivity. Cell Metabolism. In press (2007 IF 17.2).

3. IMMUNITY & INFLAMMATION

van Vliet, C., Bukczynska, P.E., Puryer, M.A., Sadek, C.M., Shields, B., Tremblay, M.L., & Tiganis, T. (2005) Selective regulation of TNF-induced ERK signalling by Src family kinases & the T-cell protein tyrosine phosphatase. Nat. Immunol. 6, 253-260 (2005 IF = 28.1)

Lu, X., Malumbres, R., Shields, B., Natkunam, Y., Sarosiek, K.A., Jiang, X., Tiganis, T.,* & Lossos, I.S.* (2008) PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood. 112, 4098-108. (2007 IF 10.9) * co-corresponding authors