Telephone: +61 - 3 9902 9226
Structural and Biophysical Studies of Macromolecular Interactions
My research focuses on the study of protein-peptide and protein-oligonucleotide interactions that occur in human cells to control gene expression, cell growth and cell proliferation.
The laboratory, run jointly with A/Prof Matthew Wilce, aims to better understand molecular recognition by determining the overall shapes, as well as the precise three-dimensional structures of macromolecular complexes, and by testing their affinity and specificity using biophysical techniques. We investigate several molecular systems involved in cell inflammation and cancer cell migration. These include the study of proteins which bind to mRNA and regulate translation (in collaboration with Dr Myriam Gorospe, NIH), proteins which recognise RNA in innate immunity (in collaboration with Professor Bryan Williams, MIMR) and the development of peptides which inhibit cancer cell proliferation and migration (in collaboration with Professor Krag and Dr Stephanie Pero, USA).