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Professor Ian Smith
Deputy Dean, Research
Ian Smith is a Professorial Fellow in the Department of Biochemistry, Director of the Monash Biomedical Proteomics Facility and head of the Peptide Biology Laboratory. His research focuses on the role and regulation of proteases involved in the generation and metabolism of peptide regulators of cardiovascular function and the design and analysis of protease inhibitors as research tools and potential therapeutics. His research is well-recognised internationally; for example, in the last five years he has received 10 invitations to speak (6 as a plenary speaker) at international meetings. He serves on several editorial boards including; J Neurochemistry (handling editor), Mol & Cell Proteomics, Protein & Peptide Letters and Int. J. Peptide Res and Therap. He has published over 170 papers including peer reviewed research papers in major international journals such as Science, Lancet, J Clin Invest, J. Biol Chem and FASEB, book chapters and invited reviews. He has collaborated with pharmaceutical and biotechnology companies and has filed seven patents. He is a co-founder of the proteomics-based, publicly listed, biotechnology company, Cryptome Pharmaceuticals Pty Ltd., is a non-executive director of Auspep Pty Ltd., and a consultant to Mayne Pharma. For the last four years he has been a member of the NH&MRC grant review panel for Biochemistry, the last two as chairman. This year he will convene and chair the NH&MRC program committee for a special Glucosamine Research study, as well as sitting on NH&MRC project grants committee. Over the years he has been involved in a number of national and international societies and in the organisation of numerous scientific meetings. He is currently a member of Lorne Protein committee, co-president of the Australian Peptide Association, the Australia/New Zealand representative on the International Peptide Liaison committee and convenor and Co-Chairman for the IVth International Peptide Congress, Cairns, 2007
Research Interests:
- Central and peripheral peptide regulators of cardiovascular function
- Endothelial cell peptidases involved in regulating cerebrovascular function.
- Peptidases involved in the biosynthesis and metabolism of neuropeptides.
- Design, synthesis and functional analysis of specific metalloendopeptidase inhibitors.
- Biomedical and Translational Proteomics
Current Research Projects:
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