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Dr. Ashley Buckle Publications

2006

  • Hennebry, S. C., Law R. H. P., Richardson, S. J., Whisstock, J. C. and Buckle A. M. (2006) The crystal structure of a transthyretin-like protein from salmonella Dublin, a prokaryote 5-hydroxyisourate hydrolase. J. Mol. Biol. In press. (Joint corresponding author)
  • Law, H. P., Zhang, W, McGowan, S., Buckle, A. M., Silverman, G. A., Wong, W, Rosado, C. J., Langendorf, C. G., Pike, R. N., Bird, P. I., and Whisstock, J. C. (2006) An Overview of the Serpin Family.  Genome Biology. In press
  • Chow M. K., Amin A. A., Fulton K. F., Whisstock J. C., Bottomley S. P., Buckle A. M. (2005) REFOLD: An analytical database of protein refolding methods.  Protein Expr Purif., 46, 166-71.
  • Amin, A. A., Faux, N. G., Fenalti, G. Williams. G., Bernadou, B., Daglish, B., Keefe, K., Middleton, S., Rae, J., Tetis, K., Law, H.P., Fulton, K. F., Rossjohn J., Whisstock, J. C. & Buckle, A. M. (2005) Managing and Mining Protein Crystallization Data.  PROTEINS: Structure, Function, and Bioinformatics. 62, 4-7.
  • Chow, M. K., Amin, A. A., Fulton, K. F., Fernando, T., Kamau, L., Batty, C., Louca, M., Ho, S., Whisstock, J. C., Bottomley, S. P., & Buckle, A. M., (2005) The REFOLD database: a tool for the optimization of protein expression and refolding. Nucleic Acids Research 34, D207-12.
  • McGowan S, Buckle AM, Irving JA, Ong PC, Bashtannyk-Puhalovich TA, Kan W-T, Henderson KN, Bulynko YA, Popova EY, Smith AI, Bottomley SP, Rossjohn J, Grigoryev SA, Pike RN & Whisstock JC (2006) X-Ray crystal structure of MENT: Evidence for functional loop-sheet polymers in chromatin condensation. EMBO J. (in press).

2005

  • Buckle A. M., Tynan F. E., Burrows S. R., Clements C. S., Borg N. A., Miles J. J., Beddoe T., Whisstock J. C., Wilce M. C., Silins S. L., Burrows J. M, Kjer-Nielsen L., Kostenko L., Purcell A. W., McCluskey J., Rossjohn J. (2005).  T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nature Immunology, 11, 1114-22 (joint 1st author)
  • Fulton, K. F., Devlin, G., Silvestri, L., Fersht, A. R. & Buckle, A. M. (2005) PFD: A Database for the Investigation of Protein Folding Kinetics and Stability. Nucleic Acids Research, 33, D279-83.
  • Buckle, A. M., Fulton, K. F., Cabrita, L. D., Irving, J. A., Butcher, R. E., Lesk, A. M., Bottomley, S. P., Rossjohn, J. & Whisstock, J. C. (2005) The High Resolution Crystal Structure of a Native Thermostable Serpin Reveals the Complex Mechanism Underpinning the Stressed to Relaxed Transition.   J. Biol. Chem. 280, 8435-42 (joint 1st author)
  • Buckle, A. M., Devlin, G. L., Jodun, R., Fulton, K. F., Faux, N. & Bottomley, S. P. (2005) The Matrix Refolded. Nature Methods, 2, 3.
  • Buckle, A. M., Law, H.P., Ruzyla, K., Buzza, M., Bashtannyk-Puhalovich, Beddoe, T. C., Nguyen, Worrall, M., Bottomley, S. P., Bird, P. I., Rossjohn, J. & Whisstock, J. C.  (2005) The High Resolution Crystal Structure of the Human Tumour Suppressor Maspin Reveals a Novel Conformational Switch in the G-helix.  J. Biol. Chem. 280, 22356-64 (joint 1st author)
  • Wilmann, P. G., Petersen, J., Pettikiriarachchi, A. Z., Buckle, A. M., Perugini, M., Devenish,, R. J., Prescott, M. and Rossjohn, J. (2005). The 2.1 Å crystal structure of the dimeric far-red fluorescent protein HcRed: inherent conformational flexibility of the chromophore. J. Mol. Biol, 349, 223-37.
  • Pike R. N., Buckle A. M., le Bonniec B. F., Church F. C. (2005) Control of the coagulation system by serpins: getting by with a little help from glycosaminoglycans. FEBS J. 272, 4842-51.

2004

  • Smethurst, P. A., Joutsi-Korhonen, L., O'Connor, M. N., Wilson, E., Jennings, N. S., Garner, S. F., Zhang, Y., Knight, C. G., Dafforn, T. R., Buckle, A., Ijsseldijk, M. J., De Groot, P. G., Watkins, N. A., Farndale, R. W. & Ouwehand W. H. (2004) Identification of the primary collagen binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody.  Blood 103, 903-911.
  • Fulton, K. F., Forster, R., Jodun, R. Ervine, S., Ly, W., Robilliard, L., Sonsini, J., Whelan, D., Whisstock, J. C. & Buckle, A. M. (2004).  CLIMS: Crystallography Laboratory Information Management System. Acta Crystallogr D Biol Crystallogr. 60, 1691-1693

2003

  • Fulton, K. F. Jackson, S. E. & Buckle, A. M. (2003) Energetic and Structural Analysis of the Role of Tryptophan 59 in FKBP12. Biochemistry 42, 2364-72.
  • Allen, M. D, Buckle, A. M., Cordell, S. C., Lowe, J. & Bycroft, M. (2003). The crystal structure of AF1521 a protein from Archaeoglobus fulgidus with homology to the non-histone domain of macroH2A. J. Mol. Biol. 330, 503-11.

2002

  • Vaughan, C., Harryson, P., Buckle, A. M. & Fersht, A. R. (2002).  A structural double mutant cycle: Estimating the strength of a buried salt bridge in barnase. Acta Crystallogr D Biol Crystallogr. 58, 591-600
  • Kazmirski, S. L., Isaacson, R. L., An C., Buckle, A. M., Johnson, C. M., Daggett, V. & Fersht, A. R.  (2002). Loss of a metal binding site in gelsolin leads to familial amyloidosis-Finnish type. Nature. Structural Biology  9, 112-116

2001

  • Smoot, A. L., Panda, M., Brazil, B. T., Buckle, A. M., Fersht, A. R. & Horowitz, P. M. (2001) The Binding of bis-ANS to the Isolated GroEL apical domain fragment induces the formation of a folding intermediate with increased hydrophobic surface exposure not observed in tetradecameric GroEL. Biochemistry 40, 4484-4492
  • Wang, W. K., Bycroft, M., Foster, N. W., Buckle, A. M., Fersht, A. R. & Chen, Y. W. (2001). Structure of the C-terminal sterile -motif (SAM) domain of human p73a.   Acta Crystallogr D Biol Crystallogr. D57, 545-551.

2000

  • Wang, Q., Buckle, A. M. & Fersht, A. R. (2000) Stabilization of GroEL minichaperones by Core and Surface Mutations. J. Mol. Biol. 298, 917-926.
  • Wang, Q., Buckle, A. M. & Fersht, A. R. (2000) From minichaperone to GroEL 1: Information on GroEL-polypeptide interactions from crystal packing of minichaperones. J. Mol. Biol. 304, 873-881.
  • Wang, W. K., Proctor, M., Buckle, A. M., Wong, K., Bycroft, M.  & Chen, Y. W. (2000) Crystallization and preliminary crystallographic studies of a SAM domain at the C-terminus of human p73a. Acta Crystallogr D Biol Crystallogr D56, 769-771.

1999

  • Vaughan, C. K., Buckle, A. M. & Fersht, A. R. (1999) Structural response to mutation at a protein-protein interface. J. Mol. Biol. 286, 1487-1506.
  • Wang, Q., Buckle, A. M., Foster, N. F., Johnson, C. M. & Fersht, A. R. (1999) Design of highly stable functional GroEL minichaperones. Protein Science 8, 2186-2193.
  • Chatellier, J., Buckle, A. M. & Fersht, A. M. (1999) GroEL recognises sequential and non-sequential linear structural motifs compatible with extended beta-strands and alpha-helices. J. Mol. Biol. 292, 163-172.

1997

  • Buckle, A. M., Zahn, R. & Fersht, A. R. (1997) A structural model for GroEL-polypeptide recognition.  Proc. Natl. Acad. Sci. USA 94, 3571-3575.
  • Altamirano, M. M, Golbik, R., Zahn, R., Buckle, A. M. & Fersht, A. R. (1997) Refolding chromatography with immobilized mini-chaperones.  Proc. Natl. Acad. Sci. USA 94, 3576-3578.

1996

  • Neira, J. L., Davis, B., Ladurner, A. G., Buckle, A. M., de Prat Gay, G. & Fersht, A. R. (1996) Towards a complete structural characterization of a protein folding pathway: the structures of the denatured, transition and native states for the association/folding of two complementary fragments of cleaved chymotrypsin inhibitor 2.  Direct evidence for a nucleation-condensation mechanism. Folding & Design 1, 189-208.
  • Buckle, A. M., Cramer, P. & Fersht, A. R. (1996) The structural and energetic responses to cavity-creating mutations in hydrophobic cores: observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities. Biochemistry  35, 4298-4305.3.
  • Zahn, R., Buckle, A. M., Perret, S., Johnson, C. M., Corrales, F. J., Golbik, R. & Fersht, A. R. (1996) Chaperone activity and structure of monomeric polypeptide binding domains of GroEL.  Proc. Natl. Acad. Sci. USA 93, 15024-15029.

1994

  • Buckle, A. M. & Fersht, A. R. (1994) Subsite binding in an RNase: structure of a barnase-tetranucleotide complex at 1.76-Å resolution.  Biochemistry 33, 1644-1653.
  • Buckle, A. M., Schreiber, G. & Fersht, A. R. (1994) Protein-protein recognition: crystal structural analysis of a barnase-barstar complex at 2.0-Å resolution. Biochemistry 33, 8878-8889.
  • Schreiber, G., Buckle, A. M. & Fersht, A. R. (1994) Stability and function: two constraints in the evolution of barstar and other proteins.  Structure 2, 945-949.

1993

  • Buckle, A. M., Henrick, K. & Fersht, A. R. (1993) Crystal structural analysis of mutations in the hydrophobic cores of barnase. J. Mol. Biol. 234, 847-860.