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Paper to be Published in Nature Immunology Journal

Congratulations are extended to Onisha Patel (Rossjohn Lab), whose paper ‘A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties' has been released as an Advance Online Publication (AOP) on Nature Immunology's website: http://www.nature.com/ni/journal/vaop/ncurrent/full/ni.2051.html

This paper is a joint publication with Dale Godfrey in which Onisha was joint first author with Adam Uldrich.

On her return from a current overseas conference and lab visit, Onisha will be interviewed for an upcoming article in the Biochem Newsletter.

Abstract

Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14–joining region 18 (Vα14-Jα 18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α-GalCer-reactive NKT cells that expressed a canonical Vα10-Jα 50 TCR α-chain, which showed a preference for α-glucosylceramide (α-GlcCer) and bacterial α-glucuronic acid–containing glycolipid antigens. Structurally, despite very limited TCRα sequence identity, the Vα10 TCR–CD1d–α-GlcCer complex had a docking mode similar to that of type I TCR–CD1d–α-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses.