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The Departmental Double Digit Impact Award archive

The Department of Biochemistry and Molecular Biology has recently initiated, from 2003 onwards, the "double digit impact award". Namely, the Department will award a bottle of wine to the laboratory who publishes a paper (primary research paper or review) in a journal with an impact factor greater than 10. The laboratory has to have either first or senior authorship. CHEERS

2008

  1. Godfrey, D.I., J. Rossjohn and J. McCluskey, REVIEW: The fidelity, occasional promiscuity, and versatility of T cell receptor recognition. Immunity, 2008. 28(3): p. 304-14. Impact Factor: 19.266
  2. Petrie, E.J., C.S. Clements, J. Lin, L.C. Sullivan, D. Johnson, T. Huyton, A. Heroux, H.L. Hoare, T. Beddoe, H.H. Reid, M.C. Wilce, A.G. Brooks and J. Rossjohn, CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. J Exp Med, 2008. 205(3): p. 725-35. Impact Factor: 15.612
  3. Schessl, J., Y. Zou, M.J. McGrath, B.S. Cowling, B. Maiti, S.S. Chin, C. Sewry, R. Battini, Y. Hu, D.L. Cottle, M. Rosenblatt, L. Spruce, A. Ganguly, J. Kirschner, A.R. Judkins, J.A. Golden, H.H. Goebel, F. Muntoni, K.M. Flanigan, C.A. Mitchell and C.G. Bonnemann, Proteomic identification of FHL1 as the protein mutated in human reducing body myopathy. J Clin Invest, 2008. 118(3): p. 904-912. Impact Factor: 16.915
  4. Wimmer-Kleikamp, S.H., E. Nievergall, K. Gegenbauer, S. Adikari, M. Mansour, T. Yeadon, A.W. Boyd, N.R. Patani and M. Lackmann, Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells. Blood, 2008. 112(3) p. 721-732. Impact Factor: 10.896
  5. Wun, K.S., N.A. Borg, L. Kjer-Nielsen, T. Beddoe, R. Koh, S.K. Richardson, M. Thakur, A.R. Howell, J.P. Scott-Browne, L. Gapin, D.I. Godfrey, J. McCluskey and J. Rossjohn, A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR. J Exp Med, 2008. 205(4): p. 939-949. Impact Factor: 15.612
  6. Wynn, K.K., Z. Marland, L. Cooper, S.L. Silins, S. Gras, J.K. Archbold, F.E. Tynan, J.J. Miles, J. McCluskey, S.R. Burrows, J. Rossjohn and R. Khanna, Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection. Blood, 2008. 111(8): p. 4283-4292. Impact Factor: 10.896
  7. Wakabayashi, K., Z.X. Lian, P.S. Leung, Y. Moritoki, K. Tsuneyama, M.J. Kurth, K.S. Lam, K. Yoshida, G.X. Yang, T. Hibi, A.A. Ansari, W.M. Ridgway, R.L. Coppel, I.R. Mackay and M.E. Gershwin, Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology, 2008. 48(2): p. 531-540. Impact Factor: 10.734
  8. Chessman, D., L. Kostenko, T. Lethborg, A.W. Purcell, N.A. Williamson, Z. Chen, L. Kjer-Nielsen, N.A. Mifsud, B.D. Tait, R. Holdsworth, C.A. Almeida, D. Nolan, W.A. Macdonald, J.K. Archbold, A.D. Kellerher, D. Marriott, S. Mallal, M. Bharadwaj, J. Rossjohn and J. McCluskey, Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity. Immunity, 2008. 28(6): p. 822-32. Impact Factor: 19.266
  9. Myers, M. and P. Zimmet, COMMENT: Halting the accelerating epidemic of type 1 diabetes. Lancet, 2008. 371(9626): p. 1730-1. Impact Factor: 28.683
  10. Yang, G.X., Lian, Z.X., Chuang, Y.H., Moritoki, Y., Lan, R.Y., Wakabayashi, K., Ansari, A.A., Flavell, R.A., Ridgway, W.M., Coppel, R.L., Tsuneyama, K., Mackay, I.R., and Gershwin, M.E., Autoimmune, Cholestatic and Biliary Disease - Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice. Hepatology, 2008. 47(6): p. 1974-1982. Impact Factor: 10.734
  11. Wall, M., Poortinga, G., Hannan, K.M., Pearson, R.B., Hannan, R.D., and McArthur, G.A., Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation. Blood, 2008. E-Pub. Impact Factor: 10.896
  12. Shields, B.J., Hauser, C., Bukczynska, P., Court, N.W., and Tiganis, T., DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression. Cancer Cell, 2008. 14(2): p. 166-179. Impact Factor: 23.858
  13. Gershwin, M.E. and Mackay, I.R., Reply. Hepatology, 2008. 48(4): p. 1354-1355 Impact Factor: 10.734
  14. Lu, X., Malumbres, R., Shields, B., Jiang, X., Sarosiek, K.A., Natkunam, Y., Tiganis, T., and Lossos, I.S., PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood, 2008. E-Pub. Impact Factor: 10.896
  15. Byres, E., A.W. Paton, J.C. Paton, J. Lofling, S. D.F., M.C.J. Wilce, U.M. Talbot, D.C. Chong, H. Yu, S. Huang, X. Chen, N.M. Varki, A. Varki, J. Rossjohn, and T. Beddoe, Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature, 2008. 456(7222) p. 648-652 Impact Factor: 28.751
  16. Whisstock, J.C. and S.P. Bottomley, NEWS & VIEWS: Structural biology: Serpins' mystery solved. Nature, 2008. 455(7217): p. 1189-90. Impact Factor: 28.751
  17. Trapani, J.A. and P.I. Bird, PREVIEW: A renaissance in understanding the multiple and diverse functions of granzymes? Immunity, 2008. 29(5): p. 665-7. Impact Factor: 19.266
  18. Hsu, W., W. Zhang, K. Tsuneyama, Y. Moritoki, W.M. Ridgway, A.A. Ansari, R.L. Coppel, Z.X. Lian, I. Mackay, and M.E. Gershwin, Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha(-/-) mice. Hepatology, 2008. E-Pub. Impact Factor: 10.734

2007

1.       Borg, N.A., Wun, K.S., Kjer-Nielsen, L., Wilce, M.C., Pellicci, D.G., Koh, R., Besra, G.S., Bharadwaj, M., Godfrey, D.I., McCluskey, J., and Rossjohn, J., CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature, 2007. 448(7149) p. 44-49.Impact Factor: 26.681

2.       Faux, N.G., Huttley, G.A., Mahmood, K., Webb, G.I., Garcia de la Banda, M., and Whisstock, J.C., RCPdb: An evolutionary classification and codon usage database for repeat-containing proteins. Genome Res, 2007. 17(7): p. 1118-27. Impact Factor: 10.256

3.       Fenalti, G., Law, R.H., Buckle, A.M., Langendorf, C., Tuck, K., Rosado, C.J., Faux, N.G., Mahmood, K., Hampe, C.S., Banga, J.P., Wilce, M., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R.N., Smith, A.I., Mackay, I.R., Rowley, M.J., and Whisstock, J.C., GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop. Nat Struct Mol Biol, 2007. 14(4): p. 280-286.Impact Factor: 11.502

4.       Gershwin, M.E. and Mackay, I.R., REVIEW: The causes of primary biliary cirrhosis: Convenient and inconvenient truths. Hepatology, 2007. E-pub. Impact Factor: 10.446I

5.       Henderson, K.N., Tye-Din, J.A., Reid, H.H., Chen, Z., Borg, N.A., Beissbarth, T., Tatham, A., Mannering, S.I., Purcell, A.W., Dudek, N.L., van Heel, D.A., McCluskey, J., Rossjohn, J., and Anderson, R.P., A Structural and Immunological Basis for the Role of Human Leukocyte Antigen DQ8 in Celiac Disease. Immunity, 2007. 27(1) p. 23-34.   Impact Factor: 18.306 

6.       Horan, K.A., Watanabe, K.I., Kong, A.M., Bailey, C.G., Rasko, J.E., Sasaki, T., and Mitchell, C.A., Regulation of Fc{gamma}R-stimulated phagocytosis by the 72 kDa inositol polyphosphate 5-phosphatase: SHIP1, but not the 72 kDa 5-phosphatase, regulates complement receptor-3-mediated phagocytosis, by differential recruitment of these 5-phosphatases to the phagocytic cup. Blood, 2007. 110(13) p. 4480-4491. Impact Factor: 10.370

7.       Law, R.H., Sofian, T., Kan, W.T., Horvath, A.J., Hitchen, C.R., Langendorf, C., Buckle, A.M., Whisstock, J.C., and Coughlin, P.B., The X-ray crystal structure of the fibrinolysis inhibitor alpha2-antiplasmin Blood, 2007. E-Pub. Impact Factor: 10.370

8.       Moritoki, Y., Lian, Z.X., Wulff, H., Yang, G.X., Chuang, Y.H., Lan, R.Y., Ueno, Y., Ansari, A.A., Coppel, R.L., Mackay, I.R., and Gershwin, M.E., AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers. Hepatology, 2007. 45(2): p. 314-322. Impact Factor: 10.446

9.       Myers, G.S., Parker, D., Al-Hasani, K., Kennan, R.M., Seemann, T., Ren, Q., Badger, J.H., Selengut, J.D., Deboy, R.T., Tettelin, H., Boyce, J.D., McCarl, V.P., Han, X., Nelson, W.C., Madupu, R., Mohamoud, Y., Holley, T., Fedorova, N., Khouri, H., Bottomley, S.P., Whittington, R.J., Adler, B., Songer, J.G., Rood, J.I., and Paulsen, I.T., Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus. Nat Biotechnol, 2007. 25(5): p. 569-575. Impact Factor: 22.672

10.     Purcell, A.W., McCluskey, J., and Rossjohn, J., REVIEW: More than one reason to rethink the use of peptides in vaccine design. Nat Rev Drug Discov, 2007. 6(5): p. 404-14. Impact Factor: 20.970

11.     Ramshaw, H.S., Guthridge, M.A., Stomski, F.C., Barry, E.F., Ooms, L., Mitchell, C.A., Begley, C.G., and Lopez, A.F., The Shc binding site of the {beta}c subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis. Blood, 2007. 110(10) p. 3582-3590. Impact Factor: 10.370

12.     Rosado, C.J., Buckle, A.M., Law, R.H., Butcher, R.E., Kan, W.-T., Bird, C.H., Ung, K., Browne, K.A., Baran, K., Bashtannyk-Puhalovich, T.A., Faux, N.G., Wong, W., Porter, C.J., Pike, R.N., Ellisdon, A.M., Pearce, M.C., Bottomley, S.P., Emsley, J., Smith, A.I., Rossjohn, J., Hartland, E.L., Voskoboinik, I., Trapani, J.A., Bird, P.I., Dunstone, M.A., and Whisstock, J.C., A Common Fold Mediates Vertebrate Defense and Bacterial Attack. Science, 2007. 317(5844) p. 1548-1551. Impact Factor: 29.781

13.     Rossjohn, J. and McCluskey, J., PREVIEW: How a home-grown T cell receptor interacts with a foreign landscape. Cell, 2007. 129(1): p. 19-20. Impact Factor: 29.194 

14.     Scott-Browne, J.P., Matsuda, J.L., Mallevaey, T., White, J., Borg, N.A., McCluskey, J., Rossjohn, J., Kappler, J., Marrack, P., and Gapin, L., Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat Immunol, 2007. 8(10) p. 1105-1113. Impact Factor: 27.596

15.     Sullivan, L.C., Clements, C.S., Beddoe, T., Johnson, D., Hoare, H.L., Lin, J., Huyton, T., Hopkins, E.J., Reid, H.H., Wilce, M.C., Kabat, J., Borrego, F., Coligan, J.E., Rossjohn, J., and Brooks, A.G., The Heterodimeric Assembly of the CD94-NKG2 Receptor Family and Implications for Human Leukocyte Antigen-E Recognition. Immunity, 2007. 27(6): p. 900-11. Impact Factor: 18.306

16.     Tynan, F.E., Reid, H.H., Kjer-Nielsen, L., Miles, J.J., Wilce, M.C., Kostenko, L., Borg, N.A., Williamson, N.A., Beddoe, T., Purcell, A.W., Burrows, S.R., McCluskey, J., and Rossjohn, J., A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat Immunol, 2007. 8(3): p. 268-276. Impact Factor: 27.596

2006

Andrews Group

1.       Berndt M, Cranmer S, and Andrews RK. “Filamin A interaction with GPIba: the platelet shapes up.” Blood 107(5): p. 1745  Impact Factor 10.131

Berndt Group

2.       Boylan B, Bendt MC, Kahn M, and Newman P. “Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: Development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents.” Blood 108(3): p. 908-914  Impact Factor 10.131

3.       Liu J, Fitzgerland M, Berndt MC, Jackson C, and Kent Gartner T. “Bruton’s tyrosine kinase is essential for botrocetin/vWf-induced signalling and GPIb-dependent thrombus formation in vivo.”  Blood, 2006 E-Pub  Impact Factor 10.131

Bird Group

4.       Kaiserman D, Bird CH, Sun J, Matthews A, Ung K, Whisstock JC, Thompson PE, Trapani JE, and Bird PI, “The major human and mouse granzymes are structurally and functionally divergent.” Journal of Cell Biology 175(4): p. 619-30.  Impact Factor: 10.951

5.       Waterhouse N, Sutton V, Sedelies K, Ciccone A, Jenkins M, Turner S, Bird PI, and Trapani J. “Cytotoxic T lymphocyte-induced killing in he absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.” Journal of Cell Biology 173(1): p. 133-144  Impact Factor 10.951

Rossjohn Group

6.       Ely L, Beddoe T, Clements C, Matthews J, Purcell A, Kjer-Nielsen L, McCluskey J, and Rossjohn  J. “Disparate thermodynamics governing T cell receptor-MHC-1 interactions implicate extrinsic factors in guiding MHC restriction.” Proceedings of the NationalAcademyof Sciences of the United States of America 103(7): p. 6641-6646  Impact Factor 10.231

7.         Hoare H, Sullivan L, Pietra G, Clements C, Lee E, Ely L, Beddoe T, Falco M, Kjer-Nielsen L, Reid H, McCluskey J, Moretta L, Rossjohn J, and Brooks A. “Structural basis for a major histocompatibility complex class 1b-restricted T cell response.” Nature Immunology 7(3): p. 256-264  Impact Factor 27.011

8.       Kjer-Nielsen L, Borg N, Pellicci D, Beddoe T, Kostenko L, Clements C, Williamson N, Smyth M, Besra G, Reid H, Bharadwaj M, Godfrey D, Rossjohn J, and McCluskey, J. “A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.” Journal of Experimental Medicine 203(3): p. 661-673  Impact Factor 13.965

9.       Lucet IS, Fantino E, Styles M, Bamert R, Patel O, Broughton SE, Walter M, Burns CJ,  Treutlein H, Wilks AF, and Rossjohn J. “The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.” Blood 107(1): p. 176-83.  Impact Factor: 10.131

10.     Paton AW, Beddoe TC, Thorpe CM, Whisstock JC, Rossjohn J, and Paton JC. “AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.” Nature 443(7111): p. 548-552.    Impact Factor: 29.273

11.     Sullivan K, Hoare H, McCluskey J, Rossjohn J, and Brooks A. “A structural perspective on MHC class lb molecules in adaptive immunity.” Trends in Immunology 27(9): p. 413-420  Impact Factor 10.174

12.     Turner SJ, Doherty PC, McCluskey J, and Rossjohn J. “Structural determinants of T-cell receptor bias in immunity.” Nature Reviews Immunology, 2006 E-Pub  Impact Factor: 30.458

Williamson NA, Rossjohn J, and Purcell, AW. “Tumors reveal their secrets to cytotoxic T cells.”  Proceedings of the NationalAcademyof Sciences of the United States of America, 2006 E-Pub          Impact Factor 10.231

Mackay Group

14.     Irie J, Wu Y, Wicker L, Rainbow D, Nalesnik M, Hirsch R, Peterson L, Leung P, Cheung C, Mackay IR, Gershwin ME, and Ridgway W. “NOD.c3c4 congenic mice develop autoimmune biliary disease that seroilogically and pathogenetically models human primary biliary cirrhosis.” Journal of Experimental Medicine 203(5): p. 1209-1219  Impact Factor 13.965

Munday Group

15.     Nakamara F, Pudas R, Heikkinen O, Permi P, Kilpelainan I, Munday A, Hartwig JH, Stossel TP, and Ylanne J. “The structure of the GPIb-filamin A complex”. Blood 107(5): p. 1925-1932  Impact Factor: 10.131

Whisstock Group

16.     McGowan S, Buckle A, Irving J, Ong P, Bashtannyk-Puhalovich T, Kan W-T, Henderson K, Bulynko Y, Popova E, Smith AI, Bottomley SP, Rossjohn J, Grigoryev S, Pike RN, and Whisstock JC. “X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.”  EMBO Journal 25(13): p. 3144-3155  Impact Factor 10.053

2005

Jans Lab

  1. Glover, DJ, Lipps HJ, and Jans DA. Towards safe, non-viral therapeutic gene expression in humans. Nature Review Genetics. 6(4) 299-310. Impact Factor: 21.329

Lackmann Lab

  1. Janes, PW, Saha N, Barton WA, Kolev MV, Wimmer-Kleikamp SH, Nievergall E, Blobel CP, Himanen JP, Lackmann M, and Nikolov DB. Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans. Cell. 123(2) 291-304. Impact Factor: 28.389

Rossjohn Lab

  1. Borg NA, Ely LK, Beddoe T, Macdonald WA, Reid HH, Clements CS, Purcell AW, Kjer-Nielsen L, Miles JJ, Burrows SR, McCluskey J, and Rossjohn J. The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. Nature Immunology. 6(2) 171-80. Impact Factor: 27.586
  2. Burrows SR, Rossjohn J, and McCluskey J. Have we cut ourselves too short in mapping CTL epitopes? Trends in Immunology. E-Pub in 2005. Impact Factor: 13.975
  3. Clements CS, Kjer-Nielsen L, Kostenko L, Hoare HL, Dunstone MA, Moses E, Freed K, Brooks AG, Rossjohn J, and McCluskey J. Crystal structure of HLA-G: a nonclassical MHC class I molecule expressed at the fetal-maternal interface. Proceedings of the National Academy of Science, U S A. 102(9) 3360-5. Impact Factor: 10.452
  4. Godfrey DI, McCluskey J, and Rossjohn J. CD1d antigen presentation: treats for NKT cells. Nature Immunology. 6(8) 754-6. Impact Factor: 27.586
  5. Mannering SI, Harrison LC, Williamson NA, Morris JS, Thearle DJ, Jensen KP, Kay TW, Rossjohn J, Falk BA, Nepom GT, and Purcell AW. The insulin A-chain epitope recognized by human T cells is post-translationally modified. Journal of Experimental Medicine. 202(9) 1191-1197. Impact Factor: 14.588
  6. Turner SJ, Kedzierska K, Komodromou H, La Gruta NL, Dunstone MA, Webb AI, Webby R, Walden H, Xie W, McCluskey J, Purcell AW, Rossjohn J, and Doherty PC. Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations. Nature Immunology. 6(4) 382-9. Impact Factor: 27.586
  7. Tynan FE, Burrows SR, Buckle AM, Clements CS, Borg NA, Miles JJ, Beddoe T, Whisstock JC, Wilce MC, Silins SL, Burrows JM, Kjer-Nielsen L, Kostenko L, Purcell AW, McCluskey J, and Rossjohn J. T cell receptor
    recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide. Nature Immunology. 6(11) 1114-1122. Impact Factor: 27.586
  8. Tynan FE, Elhassen D, Purcell AW, Burrows JM, Borg NA, Miles JJ, Williamson NA, Green KJ, Tellam J, Kjer-Nielsen L, McCluskey J, Rossjohn J, and Burrows SR, The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation. Journal of Experimental Medicine. 202(9) 1249-60. Impact Factor: 14.588

Tiganis Lab

  1. Van Vliet C, Bukczynska PE, Puryer MA, Sadek CM, Shields B, Tremblay ML, and Tiganis T. Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase. Nature Immunology. 6(3) 253-60. Impact Factor: 27.586

Whisstock Lab

  1. Faux NG, Bottomley SP, Lesk AM, Irving JA, Morrison JR, de la Banda MG, and Whisstock JC. Functional insights from the distribution and role of homopeptide repeat-containing proteins. Genome Research. 15(4) 537-51. Impact Factor: 10.382

2004

Berndt Lab

  1. Mangin P, David T, Lavaud V, Cranmer S, Pikovski I, Jackson S, Berndt M, Cazenave J-P, Gachet C, and Lanza F. Identification of a novel 14-3-3 z binding site within the cytoplasmic tail of platelet glycoprotein Ib a. Blood. 104(2) 420-427. Impact Factor = 10.120
  2. Peng Y, Berndt MC, Cruz MA, and Lopez JA. The a 1 Helix- b 13 strand spanning Leu214-Val229 of platelet glycoprotein Ib a facilitates the interaction with von Willebrand factor. Blood. 104(13) 3971-3978. Impact Factor = 10.120
  3. Gardiner EE, Arthur JF, Kahn ML, Berndt MC, and Andrews RK. Regulation of platelet membrane levels of glycoprotein V1 by platelet-derived metalloproteinase. Blood. 104(12) 3611-3617. Impact Factor = 10.120

Lackmann Lab

  1. Wimmer-Kleikamp SH, Janes PW, Squires A, Bastiaens PIH, and Lackmann M. Recruitment of Eph receptors into signaling clusters does not require ephrin contact. The Journal of Cell Biology. 164(5) 661-666. Impact Factor = 12.023
  2. Himanen J-P, Chumley MJ, Lackmann M, Li C, Barton WA, Jeffrey PD, Vearing C, Geleick D, Feldheim DA, Boyd AW, Henkemeyer M, and Nikolov DN. Repelling class discrimination: ephrin-A5 binds to activates EphB2 receptor signaling. Nature Neuroscience. 7(5) 501-509. Impact Factor = 15.141

Mak Lab

  1. Paillart J-C, Shehy-Xhilaga M, Marquet R, and Mak J. Dimerization of retroviral RNA genomes: an inseperable pair. Nature Reviews Microbiology. 2(6) 461-472. Impact Factor = 13.989

Rossjohn Lab

  1. Kjer-Nielsen L, Dunstone M, Kostenko L, Ely L, Beddoe T, Mifsud N, Purcell A, Brooks A, McCluskey J, and Rossjohn J. Crystal structure of the human T cell receptor CD3 e g heterodimer complexed to the therapeutic mAb OKT3. Proceedings of the National Academy of Sciences of the United States of America. 101(20) 7675-7680. Impact Factor = 10.272
  2. Zernich D, Purcell AW, MacDonald WA, Kjer-Nielsen L, Ely LA, Laham N, Crockford T, Mifsud NA, Bharadwaj M, Chang L, Tait BD, Holdsworth R, Brooks AG, Bottomley SP, Beddoe T, Peh CA, Rossjohn J, and McCluskey J. Natural HLA Class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. Journal of Experimental Medicine. 200(1)13-24. Impact Factor = 15.302
  3. McCluskey J, Rossjohn J, and Purcell AW. TAP genes and immunity. Current Opinion in Immunology. 16(5) 651-659. Impact Factor = 12.118

Small Lab

  1. Small DH. Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease. Trends in Neurosciences, 27, 245-249. Impact Factor 12.631

2003

Brown Lab

  1. Nilsson SK, Haylock DN, Johnston HM, Occhiodor T, Brown TJ, and Simmons PJ. Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgement at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro. Blood. 101(3) 856-861. Impact Factor = 10.120

Mitchell Laboratory

  1. Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA.Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Proceedings of the National Academy of Sciences, USA. 100(15) 8660-8665 Impact Factor = 10.70

Rossjohn Laboratory

  1. Clements CS, Reid HH, Beddoe T, Tynan FE, Perugini MA, Johns TG, Bernard CC, Rossjohn J. The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis. Proceedings of the National Academy of Sciences, USA. 100(19) 11059-11064 Impact Factor = 10.700
  2. 2. Kjer-Nielsen L., Clements C. S., Purcell A. W, Brooks A. G., Whisstock J. C., Burrows S.R., McCluskey J.* & Rossjohn J. * A structural basis for the selection of dominant ab T cell receptors in anti-viral immunity. Immunity. 18(1) 53-64. Impact Factor = 17.468 (*Joint senior & corresponding author. Research paper reviewed in the journal issue).
  3. Macdonald WA, Purcell AW, Mifsud N, Ely LK, Williams DS, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J,* and McCluskey J*. A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire and T cell recognition. Journal of Experimental Medicine. 198(5) 679-691 Impact Factor = 15.837(*Joint senior & corresponding author).

Jans Laboratory

  1. Harley VR, Layfield S, Mitchell CL, Forwood JK, John AP, Briggs LJ, McDowall SG, Jans DA. Defective importin {beta} recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations. Proceedings of the National Academy of Sciences, USA. 100(12) 7045-7050. Impact Factor = 10.700
  2. Trapani J, Sutton V, Thia K, Y-Q Li, Froelich C, Jans D, Sandrin M, and Browne K. A clathrin/dynamin- and monnose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. The Journal of Cell Biology. 160(2) 223-233. Impact Factor = 12.522